HIV-1 resistance patterns to integrase inhibitors in antiretroviral-experienced patients with virological failure on raltegravir-containing regimens

Background Our aim was to study the in vivo viral genetic pathways for resistance to raltegravir, in antiretroviral-experienced patients with virological failure (VF) on raltegravir-containing regimens. Methods We set up a prospective study including antiretroviral-experienced patients receiving ral...

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Veröffentlicht in:	Journal of antimicrobial chemotherapy 2010-06, Vol.65 (6), p.1262-1269
Hauptverfasser:	da Silva, Daniel, Van Wesenbeeck, Liesbeth, Breilh, Dominique, Reigadas, Sandrine, Anies, Guerric, Van Baelen, Kurt, Morlat, Philippe, Neau, Didier, Dupon, Michel, Wittkop, Linda, Fleury, Hervé, Masquelier, Bernard
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Substitution Amino Acid Substitution - genetics Antibiotics. Antiinfectious agents. Antiparasitic agents Antiretroviral drugs Biological and medical sciences Chemotherapy Drug Resistance, Viral Drug therapy Genetics Genotype HIV HIV drug resistance HIV Infections HIV Infections - drug therapy HIV Infections - virology HIV Integrase HIV Integrase - genetics HIV Integrase Inhibitors HIV Integrase Inhibitors - pharmacology HIV Integrase Inhibitors - therapeutic use HIV-1 HIV-1 - drug effects HIV-1 - isolation & purification Human immunodeficiency virus Human immunodeficiency virus 1 Human viral diseases Humans Immunodeficiencies Immunodeficiencies. Immunoglobulinopathies Immunopathology Infectious diseases Inhibitor drugs integrase inhibitors Life Sciences Medical sciences Microbial Sensitivity Tests Microbiology and Parasitology Mutation, Missense pharmacokinetics Pharmacology. Drug treatments phenotype Prospective Studies Pyrrolidinones Pyrrolidinones - pharmacology Pyrrolidinones - therapeutic use Quinolones Quinolones - pharmacology Raltegravir Potassium resistance mutations RNA, Viral RNA, Viral - blood Sequence Analysis, DNA Treatment Failure Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids Viral Load Virology
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