Capacity of type I and II ligands to confer to estrogen receptor alpha an appropriate conformation for the recruitment of coactivators containing a LxxLL motif-Relationship with the regulation of receptor level and ERE-dependent transcription in MCF-7 cells

Estrogen receptor alpha (ERalpha) belongs to the superfamily of nuclear receptors and as such acts as a ligand-modulated transcription factor. Ligands elicit in ERalpha conformational changes leading to the recruitment of coactivators required for the transactivation of target genes via cognate resp...

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Veröffentlicht in:	Biochemical pharmacology 2010-03, Vol.79 (5), p.746-57
Hauptverfasser:	Bourgoin-Voillard, Sandrine, Gallo, Dominique, Laïos, Ioanna, Cleeren, Anny, Bali, Latifa El, Jacquot, Yves, Nonclercq, Denis, Laurent, Guy, Tabet, Jean-Claude, Leclercq, Guy
Format:	Artikel
Sprache:	eng
Schlagworte:	Chemical Sciences Organic chemistry
Online-Zugang:	Volltext
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