Petasites extract Ze 339 (PET) inhibits allergen-induced Th2 responses, airway inflammation and airway hyperreactivity in mice

Background: The herbal Petasites hybridus (butterbur) extract (Ze 339, PET) is known to have leukotriene inhibiting properties, and therefore might inhibit allergic diseases. Methods: The effect of PET was investigated in ovalbumin (OVA) immunized BALB/c mice given intranasally together with antigen...

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Veröffentlicht in:	Phytotherapy research 2010-05, Vol.24 (5), p.680-685
Hauptverfasser:	Brattström, A., Schapowal, A., Maillet, I., Schnyder, B., Ryffel, B., Moser, R.
Format:	Artikel
Sprache:	eng
Schlagworte:	airway hyperreactivity airway hyperreactivity, immune response reduction Allergens allergic airway inflammation Animals Asthma Asthma - drug therapy Asthma - immunology Asthma - physiopathology Biological and medical sciences Bronchial Hyperreactivity Bronchial Hyperreactivity - drug therapy Bronchial Hyperreactivity - immunology Bronchoalveolar Lavage Fluid Bronchoalveolar Lavage Fluid - immunology Chemokine CCL5 Chemokine CCL5 - immunology Disease Models, Animal Drug Evaluation, Preclinical Eosinophil Peroxidase Eosinophil Peroxidase - immunology Eosinophils Eosinophils - immunology General pharmacology immune response reduction Immunoglobulin E Immunoglobulin E - blood Immunology Interleukin-4 Interleukin-4 - immunology Interleukin-5 Interleukin-5 - immunology leukotriene synthesis inhibitor Life Sciences Medical sciences Mice Mice, Inbred BALB C Mucus Mucus - immunology murine asthma model Ovalbumin Petasites Petasites - chemistry Petasites extract PET Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Phytotherapy Plant Extracts Plant Extracts - pharmacology Th2 Cells Th2 Cells - drug effects Th2 Cells - immunology
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