Petasites extract Ze 339 (PET) inhibits allergen-induced Th2 responses, airway inflammation and airway hyperreactivity in mice
Background: The herbal Petasites hybridus (butterbur) extract (Ze 339, PET) is known to have leukotriene inhibiting properties, and therefore might inhibit allergic diseases. Methods: The effect of PET was investigated in ovalbumin (OVA) immunized BALB/c mice given intranasally together with antigen...
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| Veröffentlicht in: | Phytotherapy research 2010-05, Vol.24 (5), p.680-685 |
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| creator | Brattström, A. Schapowal, A. Maillet, I. Schnyder, B. Ryffel, B. Moser, R. |
| description | Background: The herbal Petasites hybridus (butterbur) extract (Ze 339, PET) is known to have leukotriene inhibiting properties, and therefore might inhibit allergic diseases.
Methods: The effect of PET was investigated in ovalbumin (OVA) immunized BALB/c mice given intranasally together with antigen challenge in the murine model of allergic airway disease (asthma) with the analysis of the inflammatory and immune parameters in the lung.
Results: PET given with the antigen challenge inhibited the allergic response. PET inhibited airway hyperresponsiveness (AHR) and eosinophil recruitment into the bronchoalveolar lavage (BAL) fluid upon allergen challenge, but had no effect in the saline control mice. Eosinophil recruitment was further assessed in the lung by eosinophil peroxidase (EPO) activity at a concentration of 100 µg PET. Microscopic investigations revealed less inflammation, eosinophil recruitment and mucus hyperproduction in the lung with 100 µg PET. Diminution of AHR and inflammation was associated with reduced IL‐4, IL‐5 and RANTES production in the BAL fluid with 30 µg PET, while OVA specific IgE and eotaxin serum levels remained unchanged.
Conclusion: PET, which has been reported to inhibit leukotriene activity, reduced allergic airway inflammation and AHR by inhibiting the production of the Th2 cytokines IL‐4 and IL‐5, and RANTES. Copyright © 2009 John Wiley & Sons, Ltd. |
| doi_str_mv | 10.1002/ptr.2972 |
| format | Article |
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Methods: The effect of PET was investigated in ovalbumin (OVA) immunized BALB/c mice given intranasally together with antigen challenge in the murine model of allergic airway disease (asthma) with the analysis of the inflammatory and immune parameters in the lung.
Results: PET given with the antigen challenge inhibited the allergic response. PET inhibited airway hyperresponsiveness (AHR) and eosinophil recruitment into the bronchoalveolar lavage (BAL) fluid upon allergen challenge, but had no effect in the saline control mice. Eosinophil recruitment was further assessed in the lung by eosinophil peroxidase (EPO) activity at a concentration of 100 µg PET. Microscopic investigations revealed less inflammation, eosinophil recruitment and mucus hyperproduction in the lung with 100 µg PET. Diminution of AHR and inflammation was associated with reduced IL‐4, IL‐5 and RANTES production in the BAL fluid with 30 µg PET, while OVA specific IgE and eotaxin serum levels remained unchanged.
Conclusion: PET, which has been reported to inhibit leukotriene activity, reduced allergic airway inflammation and AHR by inhibiting the production of the Th2 cytokines IL‐4 and IL‐5, and RANTES. Copyright © 2009 John Wiley & Sons, Ltd.</description><identifier>ISSN: 0951-418X</identifier><identifier>ISSN: 1099-1573</identifier><identifier>EISSN: 1099-1573</identifier><identifier>DOI: 10.1002/ptr.2972</identifier><identifier>PMID: 19827027</identifier><language>eng</language><publisher>Chichester, UK: John Wiley & Sons, Ltd</publisher><subject>airway hyperreactivity ; airway hyperreactivity, immune response reduction ; Allergens ; allergic airway inflammation ; Animals ; Asthma ; Asthma - drug therapy ; Asthma - immunology ; Asthma - physiopathology ; Biological and medical sciences ; Bronchial Hyperreactivity ; Bronchial Hyperreactivity - drug therapy ; Bronchial Hyperreactivity - immunology ; Bronchoalveolar Lavage Fluid ; Bronchoalveolar Lavage Fluid - immunology ; Chemokine CCL5 ; Chemokine CCL5 - immunology ; Disease Models, Animal ; Drug Evaluation, Preclinical ; Eosinophil Peroxidase ; Eosinophil Peroxidase - immunology ; Eosinophils ; Eosinophils - immunology ; General pharmacology ; immune response reduction ; Immunoglobulin E ; Immunoglobulin E - blood ; Immunology ; Interleukin-4 ; Interleukin-4 - immunology ; Interleukin-5 ; Interleukin-5 - immunology ; leukotriene synthesis inhibitor ; Life Sciences ; Medical sciences ; Mice ; Mice, Inbred BALB C ; Mucus ; Mucus - immunology ; murine asthma model ; Ovalbumin ; Petasites ; Petasites - chemistry ; Petasites extract PET ; Pharmacognosy. Homeopathy. Health food ; Pharmacology. Drug treatments ; Phytotherapy ; Plant Extracts ; Plant Extracts - pharmacology ; Th2 Cells ; Th2 Cells - drug effects ; Th2 Cells - immunology</subject><ispartof>Phytotherapy research, 2010-05, Vol.24 (5), p.680-685</ispartof><rights>Copyright © 2009 John Wiley & Sons, Ltd.</rights><rights>2015 INIST-CNRS</rights><rights>Copyright (c) 2009 John Wiley & Sons, Ltd.</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4552-1a14934036393d9f2fc749664f847df3eab736f37ce5b13e46a2cf574fdef8883</citedby><cites>FETCH-LOGICAL-c4552-1a14934036393d9f2fc749664f847df3eab736f37ce5b13e46a2cf574fdef8883</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fptr.2972$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fptr.2972$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,314,780,784,885,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22680984$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19827027$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.science/hal-00591787$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Brattström, A.</creatorcontrib><creatorcontrib>Schapowal, A.</creatorcontrib><creatorcontrib>Maillet, I.</creatorcontrib><creatorcontrib>Schnyder, B.</creatorcontrib><creatorcontrib>Ryffel, B.</creatorcontrib><creatorcontrib>Moser, R.</creatorcontrib><title>Petasites extract Ze 339 (PET) inhibits allergen-induced Th2 responses, airway inflammation and airway hyperreactivity in mice</title><title>Phytotherapy research</title><addtitle>Phytother. Res</addtitle><description>Background: The herbal Petasites hybridus (butterbur) extract (Ze 339, PET) is known to have leukotriene inhibiting properties, and therefore might inhibit allergic diseases.
Methods: The effect of PET was investigated in ovalbumin (OVA) immunized BALB/c mice given intranasally together with antigen challenge in the murine model of allergic airway disease (asthma) with the analysis of the inflammatory and immune parameters in the lung.
Results: PET given with the antigen challenge inhibited the allergic response. PET inhibited airway hyperresponsiveness (AHR) and eosinophil recruitment into the bronchoalveolar lavage (BAL) fluid upon allergen challenge, but had no effect in the saline control mice. Eosinophil recruitment was further assessed in the lung by eosinophil peroxidase (EPO) activity at a concentration of 100 µg PET. Microscopic investigations revealed less inflammation, eosinophil recruitment and mucus hyperproduction in the lung with 100 µg PET. Diminution of AHR and inflammation was associated with reduced IL‐4, IL‐5 and RANTES production in the BAL fluid with 30 µg PET, while OVA specific IgE and eotaxin serum levels remained unchanged.
Conclusion: PET, which has been reported to inhibit leukotriene activity, reduced allergic airway inflammation and AHR by inhibiting the production of the Th2 cytokines IL‐4 and IL‐5, and RANTES. Copyright © 2009 John Wiley & Sons, Ltd.</description><subject>airway hyperreactivity</subject><subject>airway hyperreactivity, immune response reduction</subject><subject>Allergens</subject><subject>allergic airway inflammation</subject><subject>Animals</subject><subject>Asthma</subject><subject>Asthma - drug therapy</subject><subject>Asthma - immunology</subject><subject>Asthma - physiopathology</subject><subject>Biological and medical sciences</subject><subject>Bronchial Hyperreactivity</subject><subject>Bronchial Hyperreactivity - drug therapy</subject><subject>Bronchial Hyperreactivity - immunology</subject><subject>Bronchoalveolar Lavage Fluid</subject><subject>Bronchoalveolar Lavage Fluid - immunology</subject><subject>Chemokine CCL5</subject><subject>Chemokine CCL5 - immunology</subject><subject>Disease Models, Animal</subject><subject>Drug Evaluation, Preclinical</subject><subject>Eosinophil Peroxidase</subject><subject>Eosinophil Peroxidase - immunology</subject><subject>Eosinophils</subject><subject>Eosinophils - immunology</subject><subject>General pharmacology</subject><subject>immune response reduction</subject><subject>Immunoglobulin E</subject><subject>Immunoglobulin E - blood</subject><subject>Immunology</subject><subject>Interleukin-4</subject><subject>Interleukin-4 - immunology</subject><subject>Interleukin-5</subject><subject>Interleukin-5 - immunology</subject><subject>leukotriene synthesis inhibitor</subject><subject>Life Sciences</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Mucus</subject><subject>Mucus - immunology</subject><subject>murine asthma model</subject><subject>Ovalbumin</subject><subject>Petasites</subject><subject>Petasites - chemistry</subject><subject>Petasites extract PET</subject><subject>Pharmacognosy. Homeopathy. Health food</subject><subject>Pharmacology. Drug treatments</subject><subject>Phytotherapy</subject><subject>Plant Extracts</subject><subject>Plant Extracts - pharmacology</subject><subject>Th2 Cells</subject><subject>Th2 Cells - drug effects</subject><subject>Th2 Cells - immunology</subject><issn>0951-418X</issn><issn>1099-1573</issn><issn>1099-1573</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp90ctuEzEUBmALgWgoSDwB8gbRSkzxbcbjZVWVBBFBVMJFbCzHc0xM54bttM2GZ2eiDOkKVkc6-vSfI_0IPafkjBLC3vQpnDEl2QM0oUSpjOaSP0QTonKaCVp-O0JPYvxJCFGMiMfoiKqSScLkBP1eQDLRJ4gY7lIwNuHvgDlX-GRxuTzFvl37lU8Rm7qG8APazLfVxkKFl2uGA8S-ayPE19j4cGu2g3e1aRqTfNdi01Z_9-ttDyHAkO9vfNo53HgLT9EjZ-oIz8Z5jD6_vVxezLL5x-m7i_N5ZkWes4waKhQXhBdc8Uo55qwUqiiEK4WsHAezkrxwXFrIV5SDKAyzLpfCVeDKsuTH6HSfuza17oNvTNjqzng9O5_r3Y6QXFFZyhs62Fd724fu1wZi0o2PFuratNBtopaci1ySQg3y5L-SikIIJSkr76kNXYwB3OELSvSuQz10qHcdDvTFmLpZNVDdw7G0AbwcgYnW1C6Y1vp4cIwVJVGlGFy2d7e-hu0_D-rF8mo8PHofE9wdvAnXupBc5vrrh6mmfDm9mr3_pL_wP7sSwOI</recordid><startdate>201005</startdate><enddate>201005</enddate><creator>Brattström, A.</creator><creator>Schapowal, A.</creator><creator>Maillet, I.</creator><creator>Schnyder, B.</creator><creator>Ryffel, B.</creator><creator>Moser, R.</creator><general>John Wiley & Sons, Ltd</general><general>Wiley</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope><scope>1XC</scope></search><sort><creationdate>201005</creationdate><title>Petasites extract Ze 339 (PET) inhibits allergen-induced Th2 responses, airway inflammation and airway hyperreactivity in mice</title><author>Brattström, A. ; Schapowal, A. ; Maillet, I. ; Schnyder, B. ; Ryffel, B. ; Moser, R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4552-1a14934036393d9f2fc749664f847df3eab736f37ce5b13e46a2cf574fdef8883</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>airway hyperreactivity</topic><topic>airway hyperreactivity, immune response reduction</topic><topic>Allergens</topic><topic>allergic airway inflammation</topic><topic>Animals</topic><topic>Asthma</topic><topic>Asthma - drug therapy</topic><topic>Asthma - immunology</topic><topic>Asthma - physiopathology</topic><topic>Biological and medical sciences</topic><topic>Bronchial Hyperreactivity</topic><topic>Bronchial Hyperreactivity - drug therapy</topic><topic>Bronchial Hyperreactivity - immunology</topic><topic>Bronchoalveolar Lavage Fluid</topic><topic>Bronchoalveolar Lavage Fluid - immunology</topic><topic>Chemokine CCL5</topic><topic>Chemokine CCL5 - immunology</topic><topic>Disease Models, Animal</topic><topic>Drug Evaluation, Preclinical</topic><topic>Eosinophil Peroxidase</topic><topic>Eosinophil Peroxidase - immunology</topic><topic>Eosinophils</topic><topic>Eosinophils - immunology</topic><topic>General pharmacology</topic><topic>immune response reduction</topic><topic>Immunoglobulin E</topic><topic>Immunoglobulin E - blood</topic><topic>Immunology</topic><topic>Interleukin-4</topic><topic>Interleukin-4 - immunology</topic><topic>Interleukin-5</topic><topic>Interleukin-5 - immunology</topic><topic>leukotriene synthesis inhibitor</topic><topic>Life Sciences</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>Mucus</topic><topic>Mucus - immunology</topic><topic>murine asthma model</topic><topic>Ovalbumin</topic><topic>Petasites</topic><topic>Petasites - chemistry</topic><topic>Petasites extract PET</topic><topic>Pharmacognosy. Homeopathy. Health food</topic><topic>Pharmacology. Drug treatments</topic><topic>Phytotherapy</topic><topic>Plant Extracts</topic><topic>Plant Extracts - pharmacology</topic><topic>Th2 Cells</topic><topic>Th2 Cells - drug effects</topic><topic>Th2 Cells - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Brattström, A.</creatorcontrib><creatorcontrib>Schapowal, A.</creatorcontrib><creatorcontrib>Maillet, I.</creatorcontrib><creatorcontrib>Schnyder, B.</creatorcontrib><creatorcontrib>Ryffel, B.</creatorcontrib><creatorcontrib>Moser, R.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><jtitle>Phytotherapy research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Brattström, A.</au><au>Schapowal, A.</au><au>Maillet, I.</au><au>Schnyder, B.</au><au>Ryffel, B.</au><au>Moser, R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Petasites extract Ze 339 (PET) inhibits allergen-induced Th2 responses, airway inflammation and airway hyperreactivity in mice</atitle><jtitle>Phytotherapy research</jtitle><addtitle>Phytother. Res</addtitle><date>2010-05</date><risdate>2010</risdate><volume>24</volume><issue>5</issue><spage>680</spage><epage>685</epage><pages>680-685</pages><issn>0951-418X</issn><issn>1099-1573</issn><eissn>1099-1573</eissn><abstract>Background: The herbal Petasites hybridus (butterbur) extract (Ze 339, PET) is known to have leukotriene inhibiting properties, and therefore might inhibit allergic diseases.
Methods: The effect of PET was investigated in ovalbumin (OVA) immunized BALB/c mice given intranasally together with antigen challenge in the murine model of allergic airway disease (asthma) with the analysis of the inflammatory and immune parameters in the lung.
Results: PET given with the antigen challenge inhibited the allergic response. PET inhibited airway hyperresponsiveness (AHR) and eosinophil recruitment into the bronchoalveolar lavage (BAL) fluid upon allergen challenge, but had no effect in the saline control mice. Eosinophil recruitment was further assessed in the lung by eosinophil peroxidase (EPO) activity at a concentration of 100 µg PET. Microscopic investigations revealed less inflammation, eosinophil recruitment and mucus hyperproduction in the lung with 100 µg PET. Diminution of AHR and inflammation was associated with reduced IL‐4, IL‐5 and RANTES production in the BAL fluid with 30 µg PET, while OVA specific IgE and eotaxin serum levels remained unchanged.
Conclusion: PET, which has been reported to inhibit leukotriene activity, reduced allergic airway inflammation and AHR by inhibiting the production of the Th2 cytokines IL‐4 and IL‐5, and RANTES. Copyright © 2009 John Wiley & Sons, Ltd.</abstract><cop>Chichester, UK</cop><pub>John Wiley & Sons, Ltd</pub><pmid>19827027</pmid><doi>10.1002/ptr.2972</doi><tpages>6</tpages></addata></record> |
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| subjects | airway hyperreactivity airway hyperreactivity, immune response reduction Allergens allergic airway inflammation Animals Asthma Asthma - drug therapy Asthma - immunology Asthma - physiopathology Biological and medical sciences Bronchial Hyperreactivity Bronchial Hyperreactivity - drug therapy Bronchial Hyperreactivity - immunology Bronchoalveolar Lavage Fluid Bronchoalveolar Lavage Fluid - immunology Chemokine CCL5 Chemokine CCL5 - immunology Disease Models, Animal Drug Evaluation, Preclinical Eosinophil Peroxidase Eosinophil Peroxidase - immunology Eosinophils Eosinophils - immunology General pharmacology immune response reduction Immunoglobulin E Immunoglobulin E - blood Immunology Interleukin-4 Interleukin-4 - immunology Interleukin-5 Interleukin-5 - immunology leukotriene synthesis inhibitor Life Sciences Medical sciences Mice Mice, Inbred BALB C Mucus Mucus - immunology murine asthma model Ovalbumin Petasites Petasites - chemistry Petasites extract PET Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Phytotherapy Plant Extracts Plant Extracts - pharmacology Th2 Cells Th2 Cells - drug effects Th2 Cells - immunology |
| title | Petasites extract Ze 339 (PET) inhibits allergen-induced Th2 responses, airway inflammation and airway hyperreactivity in mice |
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