Impact of treatment characteristics on response of different breast cancer phenotypes: pooled analysis of the German neo-adjuvant chemotherapy trials

Pathological complete response (pCR) to neoadjuvant treatment correlates with outcome in breast cancer. We determined whether characteristics of neoadjuvant therapy are associated with pCR. We used multi-level models, which accounted for heterogeneity in pCR across trials and trial arms, to analyze...

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Veröffentlicht in:	Breast cancer research and treatment 2011-01, Vol.125 (1), p.145-156
Hauptverfasser:	von Minckwitz, Gunter, Untch, Michael, Nüesch, Eveline, Loibl, Sibylle, Kaufmann, Manfred, Kümmel, Sherko, Fasching, Peter A, Eiermann, Wolfgang, Blohmer, Jens-Uwe, Costa, Serban Dan, Mehta, Keyur, Hilfrich, Jörn, Jackisch, Christian, Gerber, Bernd, du Bois, Andreas, Huober, Jens, Hanusch, Claus, Konecny, Gottfried, Fett, Werner, Stickeler, Elmar, Harbeck, Nadia, Müller, Volkmar, Jüni, Peter
Format:	Artikel
Sprache:	eng
Schlagworte:	Adjuvant treatment Adult Analysis Anthracyclines Anthracyclines trastuzumab Antineoplastic Combined Chemotherapy Protocols - therapeutic use Biological and medical sciences Biomarkers, Tumor - analysis Breast cancer breast neoplasms Breast Neoplasms - chemistry Breast Neoplasms - drug therapy Breast Neoplasms - pathology Cancer Cancer research Cancer therapies Chemotherapy Chemotherapy, Adjuvant Clinical Trial Clinical trials Clinical Trials as Topic Dose-Response Relationship, Drug Female Genetic aspects Genotype & phenotype Germany Gynecology. Andrology. Obstetrics Health aspects Humans Logistic Models Mammary gland diseases Medical sciences Medicine Medicine & Public Health Middle Aged Neoadjuvant Neoadjuvant Therapy Odds Ratio Oncology Patient Selection Phenotype Pooled analysis Risk Assessment Risk Factors Taxanes Treatment Outcome Tumors Women
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