Frequency-selectivity of a thalamocortical relay neuron during Parkinson's disease and deep brain stimulation: a computational study

In this computational study, we investigated (i) the functional importance of correlated basal ganglia (BG) activity associated with Parkinson’s disease (PD) motor symptoms by analysing the effects of globus pallidus internum (GPi) bursting frequency and synchrony on a thalamocortical (TC) relay neu...

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Veröffentlicht in:	The European journal of neuroscience 2009-10, Vol.30 (7), p.1306-1317
Hauptverfasser:	Cagnan, Hayriye, Meijer, Hil G. E., Van Gils, Stephan A., Krupa, Martin, Heida, Tjitske, Rudolph, Michelle, Wadman, Wytse J., Martens, Hubert C. F.
Format:	Artikel
Sprache:	eng
Schlagworte:	Algorithms basal ganglia Brain Brain - physiopathology Calcium Calcium - metabolism Cerebral Cortex Cerebral Cortex - physiopathology Computer Simulation Deep Brain Stimulation Deep Brain Stimulation - methods Dendrites Dendrites - physiology Dyskinesias Dyskinesias - physiopathology Dyskinesias - therapy gamma-Aminobutyric Acid gamma-Aminobutyric Acid - metabolism Globus Pallidus Globus Pallidus - physiopathology high-frequency stimulation Humans Life Sciences Membrane Potentials Models, Neurological modulation Neural Pathways Neural Pathways - physiopathology Neurons Neurons - physiology Neurons and Cognition Parkinson Disease Parkinson Disease - physiopathology Parkinson Disease - therapy Periodicity relay Subthalamic Nucleus Subthalamic Nucleus - physiopathology
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