Frequency-selectivity of a thalamocortical relay neuron during Parkinson's disease and deep brain stimulation: a computational study

In this computational study, we investigated (i) the functional importance of correlated basal ganglia (BG) activity associated with Parkinson’s disease (PD) motor symptoms by analysing the effects of globus pallidus internum (GPi) bursting frequency and synchrony on a thalamocortical (TC) relay neu...

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Veröffentlicht in:The European journal of neuroscience 2009-10, Vol.30 (7), p.1306-1317
Hauptverfasser: Cagnan, Hayriye, Meijer, Hil G. E., Van Gils, Stephan A., Krupa, Martin, Heida, Tjitske, Rudolph, Michelle, Wadman, Wytse J., Martens, Hubert C. F.
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container_issue 7
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container_title The European journal of neuroscience
container_volume 30
creator Cagnan, Hayriye
Meijer, Hil G. E.
Van Gils, Stephan A.
Krupa, Martin
Heida, Tjitske
Rudolph, Michelle
Wadman, Wytse J.
Martens, Hubert C. F.
description In this computational study, we investigated (i) the functional importance of correlated basal ganglia (BG) activity associated with Parkinson’s disease (PD) motor symptoms by analysing the effects of globus pallidus internum (GPi) bursting frequency and synchrony on a thalamocortical (TC) relay neuron, which received GABAergic projections from this nucleus; (ii) the effects of subthalamic nucleus (STN) deep brain stimulation (DBS) on the response of the TC relay neuron to synchronized GPi oscillations; and (iii) the functional basis of the inverse relationship that has been reported between DBS frequency and stimulus amplitude, required to alleviate PD motor symptoms [A. L. Benabid et al. (1991)Lancet, 337, 403–406]. The TC relay neuron selectively responded to and relayed synchronized GPi inputs bursting at a frequency located in the range 2–25 Hz. Input selectivity of the TC relay neuron is dictated by low‐threshold calcium current dynamics and passive membrane properties of the neuron. STN‐DBS prevented the TC relay neuron from relaying synchronized GPi oscillations to cortex. Our model indicates that DBS alters BG output and input selectivity of the TC relay neuron, providing an explanation for the clinically observed inverse relationship between DBS frequency and stimulus amplitude.
doi_str_mv 10.1111/j.1460-9568.2009.06922.x
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subjects Algorithms
basal ganglia
Brain
Brain - physiopathology
Calcium
Calcium - metabolism
Cerebral Cortex
Cerebral Cortex - physiopathology
Computer Simulation
Deep Brain Stimulation
Deep Brain Stimulation - methods
Dendrites
Dendrites - physiology
Dyskinesias
Dyskinesias - physiopathology
Dyskinesias - therapy
gamma-Aminobutyric Acid
gamma-Aminobutyric Acid - metabolism
Globus Pallidus
Globus Pallidus - physiopathology
high-frequency stimulation
Humans
Life Sciences
Membrane Potentials
Models, Neurological
modulation
Neural Pathways
Neural Pathways - physiopathology
Neurons
Neurons - physiology
Neurons and Cognition
Parkinson Disease
Parkinson Disease - physiopathology
Parkinson Disease - therapy
Periodicity
relay
Subthalamic Nucleus
Subthalamic Nucleus - physiopathology
title Frequency-selectivity of a thalamocortical relay neuron during Parkinson's disease and deep brain stimulation: a computational study
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