Frequency-selectivity of a thalamocortical relay neuron during Parkinson's disease and deep brain stimulation: a computational study
In this computational study, we investigated (i) the functional importance of correlated basal ganglia (BG) activity associated with Parkinson’s disease (PD) motor symptoms by analysing the effects of globus pallidus internum (GPi) bursting frequency and synchrony on a thalamocortical (TC) relay neu...
Gespeichert in:
Veröffentlicht in: | The European journal of neuroscience 2009-10, Vol.30 (7), p.1306-1317 |
---|---|
Hauptverfasser: | , , , , , , , |
Format: | Artikel |
Sprache: | eng |
Schlagworte: | |
Online-Zugang: | Volltext |
Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
container_end_page | 1317 |
---|---|
container_issue | 7 |
container_start_page | 1306 |
container_title | The European journal of neuroscience |
container_volume | 30 |
creator | Cagnan, Hayriye Meijer, Hil G. E. Van Gils, Stephan A. Krupa, Martin Heida, Tjitske Rudolph, Michelle Wadman, Wytse J. Martens, Hubert C. F. |
description | In this computational study, we investigated (i) the functional importance of correlated basal ganglia (BG) activity associated with Parkinson’s disease (PD) motor symptoms by analysing the effects of globus pallidus internum (GPi) bursting frequency and synchrony on a thalamocortical (TC) relay neuron, which received GABAergic projections from this nucleus; (ii) the effects of subthalamic nucleus (STN) deep brain stimulation (DBS) on the response of the TC relay neuron to synchronized GPi oscillations; and (iii) the functional basis of the inverse relationship that has been reported between DBS frequency and stimulus amplitude, required to alleviate PD motor symptoms [A. L. Benabid et al. (1991)Lancet, 337, 403–406]. The TC relay neuron selectively responded to and relayed synchronized GPi inputs bursting at a frequency located in the range 2–25 Hz. Input selectivity of the TC relay neuron is dictated by low‐threshold calcium current dynamics and passive membrane properties of the neuron. STN‐DBS prevented the TC relay neuron from relaying synchronized GPi oscillations to cortex. Our model indicates that DBS alters BG output and input selectivity of the TC relay neuron, providing an explanation for the clinically observed inverse relationship between DBS frequency and stimulus amplitude. |
doi_str_mv | 10.1111/j.1460-9568.2009.06922.x |
format | Article |
fullrecord | <record><control><sourceid>proquest_hal_p</sourceid><recordid>TN_cdi_hal_primary_oai_HAL_hal_00586797v1</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>734075761</sourcerecordid><originalsourceid>FETCH-LOGICAL-c5212-6910dc4ff22a301da8ae5c7f4e2d0b93b0525842ddeb7ea2c20de04505722e593</originalsourceid><addsrcrecordid>eNqNkc1v0zAYhyMEYt3gX0A-MXFIsZ3YTpA4jLKtoGhwGIKb5dhvwCWJi51szZ0_HGetyg3hi7-e3-uPJ0kQwUsS2-vNkuQcpyXjxZJiXC4xLyld7h4li-PG42SBS5alBeHfTpLTEDYY44Ln7GlyQkpRFEyIRfL7ysOvEXo9pQFa0IO9s8OEXIMUGn6oVnVOOz9YrVrkoVUT6mH0rkdm9Lb_jj4r_9P2wfXnARkbQAVAqjfIAGxR7ZXtURhsN7ZqsK5_E6tq123H4WEaa4ZhNNOz5Emj2gDPD_1Z8uXq8na1TqtP1x9WF1WqGSU05SXBRudNQ6nKMDGqUMC0aHKgBtdlVmNGWZFTY6AWoKim2ADOGWaCUmBldpa82teND5NbbzvlJ-mUleuLSs5rGLOCi1Lckcie79mtd_GDwiA7GzS0rerBjUGKLMeCCT6TL_9JUkLyMuM0gsUe1N6F4KE53oFgOXuVGznrk7M-OXuVD17lLkZfHM4Y6w7M3-BBZATe7oF728L034Xl5cebeRTz6T5vwwC7Yz7alVxkgsmvN9dSrN7frqt3leTZH7D0wmc</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>21149362</pqid></control><display><type>article</type><title>Frequency-selectivity of a thalamocortical relay neuron during Parkinson's disease and deep brain stimulation: a computational study</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Cagnan, Hayriye ; Meijer, Hil G. E. ; Van Gils, Stephan A. ; Krupa, Martin ; Heida, Tjitske ; Rudolph, Michelle ; Wadman, Wytse J. ; Martens, Hubert C. F.</creator><creatorcontrib>Cagnan, Hayriye ; Meijer, Hil G. E. ; Van Gils, Stephan A. ; Krupa, Martin ; Heida, Tjitske ; Rudolph, Michelle ; Wadman, Wytse J. ; Martens, Hubert C. F.</creatorcontrib><description>In this computational study, we investigated (i) the functional importance of correlated basal ganglia (BG) activity associated with Parkinson’s disease (PD) motor symptoms by analysing the effects of globus pallidus internum (GPi) bursting frequency and synchrony on a thalamocortical (TC) relay neuron, which received GABAergic projections from this nucleus; (ii) the effects of subthalamic nucleus (STN) deep brain stimulation (DBS) on the response of the TC relay neuron to synchronized GPi oscillations; and (iii) the functional basis of the inverse relationship that has been reported between DBS frequency and stimulus amplitude, required to alleviate PD motor symptoms [A. L. Benabid et al. (1991)Lancet, 337, 403–406]. The TC relay neuron selectively responded to and relayed synchronized GPi inputs bursting at a frequency located in the range 2–25 Hz. Input selectivity of the TC relay neuron is dictated by low‐threshold calcium current dynamics and passive membrane properties of the neuron. STN‐DBS prevented the TC relay neuron from relaying synchronized GPi oscillations to cortex. Our model indicates that DBS alters BG output and input selectivity of the TC relay neuron, providing an explanation for the clinically observed inverse relationship between DBS frequency and stimulus amplitude.</description><identifier>ISSN: 0953-816X</identifier><identifier>EISSN: 1460-9568</identifier><identifier>DOI: 10.1111/j.1460-9568.2009.06922.x</identifier><identifier>PMID: 19788577</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Algorithms ; basal ganglia ; Brain ; Brain - physiopathology ; Calcium ; Calcium - metabolism ; Cerebral Cortex ; Cerebral Cortex - physiopathology ; Computer Simulation ; Deep Brain Stimulation ; Deep Brain Stimulation - methods ; Dendrites ; Dendrites - physiology ; Dyskinesias ; Dyskinesias - physiopathology ; Dyskinesias - therapy ; gamma-Aminobutyric Acid ; gamma-Aminobutyric Acid - metabolism ; Globus Pallidus ; Globus Pallidus - physiopathology ; high-frequency stimulation ; Humans ; Life Sciences ; Membrane Potentials ; Models, Neurological ; modulation ; Neural Pathways ; Neural Pathways - physiopathology ; Neurons ; Neurons - physiology ; Neurons and Cognition ; Parkinson Disease ; Parkinson Disease - physiopathology ; Parkinson Disease - therapy ; Periodicity ; relay ; Subthalamic Nucleus ; Subthalamic Nucleus - physiopathology</subject><ispartof>The European journal of neuroscience, 2009-10, Vol.30 (7), p.1306-1317</ispartof><rights>The Authors (2009). Journal Compilation © Federation of European Neuroscience Societies and Blackwell Publishing Ltd</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5212-6910dc4ff22a301da8ae5c7f4e2d0b93b0525842ddeb7ea2c20de04505722e593</citedby><cites>FETCH-LOGICAL-c5212-6910dc4ff22a301da8ae5c7f4e2d0b93b0525842ddeb7ea2c20de04505722e593</cites><orcidid>0000-0002-8540-7808</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1460-9568.2009.06922.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1460-9568.2009.06922.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,314,776,780,881,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19788577$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.science/hal-00586797$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Cagnan, Hayriye</creatorcontrib><creatorcontrib>Meijer, Hil G. E.</creatorcontrib><creatorcontrib>Van Gils, Stephan A.</creatorcontrib><creatorcontrib>Krupa, Martin</creatorcontrib><creatorcontrib>Heida, Tjitske</creatorcontrib><creatorcontrib>Rudolph, Michelle</creatorcontrib><creatorcontrib>Wadman, Wytse J.</creatorcontrib><creatorcontrib>Martens, Hubert C. F.</creatorcontrib><title>Frequency-selectivity of a thalamocortical relay neuron during Parkinson's disease and deep brain stimulation: a computational study</title><title>The European journal of neuroscience</title><addtitle>Eur J Neurosci</addtitle><description>In this computational study, we investigated (i) the functional importance of correlated basal ganglia (BG) activity associated with Parkinson’s disease (PD) motor symptoms by analysing the effects of globus pallidus internum (GPi) bursting frequency and synchrony on a thalamocortical (TC) relay neuron, which received GABAergic projections from this nucleus; (ii) the effects of subthalamic nucleus (STN) deep brain stimulation (DBS) on the response of the TC relay neuron to synchronized GPi oscillations; and (iii) the functional basis of the inverse relationship that has been reported between DBS frequency and stimulus amplitude, required to alleviate PD motor symptoms [A. L. Benabid et al. (1991)Lancet, 337, 403–406]. The TC relay neuron selectively responded to and relayed synchronized GPi inputs bursting at a frequency located in the range 2–25 Hz. Input selectivity of the TC relay neuron is dictated by low‐threshold calcium current dynamics and passive membrane properties of the neuron. STN‐DBS prevented the TC relay neuron from relaying synchronized GPi oscillations to cortex. Our model indicates that DBS alters BG output and input selectivity of the TC relay neuron, providing an explanation for the clinically observed inverse relationship between DBS frequency and stimulus amplitude.</description><subject>Algorithms</subject><subject>basal ganglia</subject><subject>Brain</subject><subject>Brain - physiopathology</subject><subject>Calcium</subject><subject>Calcium - metabolism</subject><subject>Cerebral Cortex</subject><subject>Cerebral Cortex - physiopathology</subject><subject>Computer Simulation</subject><subject>Deep Brain Stimulation</subject><subject>Deep Brain Stimulation - methods</subject><subject>Dendrites</subject><subject>Dendrites - physiology</subject><subject>Dyskinesias</subject><subject>Dyskinesias - physiopathology</subject><subject>Dyskinesias - therapy</subject><subject>gamma-Aminobutyric Acid</subject><subject>gamma-Aminobutyric Acid - metabolism</subject><subject>Globus Pallidus</subject><subject>Globus Pallidus - physiopathology</subject><subject>high-frequency stimulation</subject><subject>Humans</subject><subject>Life Sciences</subject><subject>Membrane Potentials</subject><subject>Models, Neurological</subject><subject>modulation</subject><subject>Neural Pathways</subject><subject>Neural Pathways - physiopathology</subject><subject>Neurons</subject><subject>Neurons - physiology</subject><subject>Neurons and Cognition</subject><subject>Parkinson Disease</subject><subject>Parkinson Disease - physiopathology</subject><subject>Parkinson Disease - therapy</subject><subject>Periodicity</subject><subject>relay</subject><subject>Subthalamic Nucleus</subject><subject>Subthalamic Nucleus - physiopathology</subject><issn>0953-816X</issn><issn>1460-9568</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkc1v0zAYhyMEYt3gX0A-MXFIsZ3YTpA4jLKtoGhwGIKb5dhvwCWJi51szZ0_HGetyg3hi7-e3-uPJ0kQwUsS2-vNkuQcpyXjxZJiXC4xLyld7h4li-PG42SBS5alBeHfTpLTEDYY44Ln7GlyQkpRFEyIRfL7ysOvEXo9pQFa0IO9s8OEXIMUGn6oVnVOOz9YrVrkoVUT6mH0rkdm9Lb_jj4r_9P2wfXnARkbQAVAqjfIAGxR7ZXtURhsN7ZqsK5_E6tq123H4WEaa4ZhNNOz5Emj2gDPD_1Z8uXq8na1TqtP1x9WF1WqGSU05SXBRudNQ6nKMDGqUMC0aHKgBtdlVmNGWZFTY6AWoKim2ADOGWaCUmBldpa82teND5NbbzvlJ-mUleuLSs5rGLOCi1Lckcie79mtd_GDwiA7GzS0rerBjUGKLMeCCT6TL_9JUkLyMuM0gsUe1N6F4KE53oFgOXuVGznrk7M-OXuVD17lLkZfHM4Y6w7M3-BBZATe7oF728L034Xl5cebeRTz6T5vwwC7Yz7alVxkgsmvN9dSrN7frqt3leTZH7D0wmc</recordid><startdate>200910</startdate><enddate>200910</enddate><creator>Cagnan, Hayriye</creator><creator>Meijer, Hil G. E.</creator><creator>Van Gils, Stephan A.</creator><creator>Krupa, Martin</creator><creator>Heida, Tjitske</creator><creator>Rudolph, Michelle</creator><creator>Wadman, Wytse J.</creator><creator>Martens, Hubert C. F.</creator><general>Blackwell Publishing Ltd</general><general>Wiley</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope><scope>1XC</scope><orcidid>https://orcid.org/0000-0002-8540-7808</orcidid></search><sort><creationdate>200910</creationdate><title>Frequency-selectivity of a thalamocortical relay neuron during Parkinson's disease and deep brain stimulation: a computational study</title><author>Cagnan, Hayriye ; Meijer, Hil G. E. ; Van Gils, Stephan A. ; Krupa, Martin ; Heida, Tjitske ; Rudolph, Michelle ; Wadman, Wytse J. ; Martens, Hubert C. F.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5212-6910dc4ff22a301da8ae5c7f4e2d0b93b0525842ddeb7ea2c20de04505722e593</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Algorithms</topic><topic>basal ganglia</topic><topic>Brain</topic><topic>Brain - physiopathology</topic><topic>Calcium</topic><topic>Calcium - metabolism</topic><topic>Cerebral Cortex</topic><topic>Cerebral Cortex - physiopathology</topic><topic>Computer Simulation</topic><topic>Deep Brain Stimulation</topic><topic>Deep Brain Stimulation - methods</topic><topic>Dendrites</topic><topic>Dendrites - physiology</topic><topic>Dyskinesias</topic><topic>Dyskinesias - physiopathology</topic><topic>Dyskinesias - therapy</topic><topic>gamma-Aminobutyric Acid</topic><topic>gamma-Aminobutyric Acid - metabolism</topic><topic>Globus Pallidus</topic><topic>Globus Pallidus - physiopathology</topic><topic>high-frequency stimulation</topic><topic>Humans</topic><topic>Life Sciences</topic><topic>Membrane Potentials</topic><topic>Models, Neurological</topic><topic>modulation</topic><topic>Neural Pathways</topic><topic>Neural Pathways - physiopathology</topic><topic>Neurons</topic><topic>Neurons - physiology</topic><topic>Neurons and Cognition</topic><topic>Parkinson Disease</topic><topic>Parkinson Disease - physiopathology</topic><topic>Parkinson Disease - therapy</topic><topic>Periodicity</topic><topic>relay</topic><topic>Subthalamic Nucleus</topic><topic>Subthalamic Nucleus - physiopathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cagnan, Hayriye</creatorcontrib><creatorcontrib>Meijer, Hil G. E.</creatorcontrib><creatorcontrib>Van Gils, Stephan A.</creatorcontrib><creatorcontrib>Krupa, Martin</creatorcontrib><creatorcontrib>Heida, Tjitske</creatorcontrib><creatorcontrib>Rudolph, Michelle</creatorcontrib><creatorcontrib>Wadman, Wytse J.</creatorcontrib><creatorcontrib>Martens, Hubert C. F.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><jtitle>The European journal of neuroscience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cagnan, Hayriye</au><au>Meijer, Hil G. E.</au><au>Van Gils, Stephan A.</au><au>Krupa, Martin</au><au>Heida, Tjitske</au><au>Rudolph, Michelle</au><au>Wadman, Wytse J.</au><au>Martens, Hubert C. F.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Frequency-selectivity of a thalamocortical relay neuron during Parkinson's disease and deep brain stimulation: a computational study</atitle><jtitle>The European journal of neuroscience</jtitle><addtitle>Eur J Neurosci</addtitle><date>2009-10</date><risdate>2009</risdate><volume>30</volume><issue>7</issue><spage>1306</spage><epage>1317</epage><pages>1306-1317</pages><issn>0953-816X</issn><eissn>1460-9568</eissn><abstract>In this computational study, we investigated (i) the functional importance of correlated basal ganglia (BG) activity associated with Parkinson’s disease (PD) motor symptoms by analysing the effects of globus pallidus internum (GPi) bursting frequency and synchrony on a thalamocortical (TC) relay neuron, which received GABAergic projections from this nucleus; (ii) the effects of subthalamic nucleus (STN) deep brain stimulation (DBS) on the response of the TC relay neuron to synchronized GPi oscillations; and (iii) the functional basis of the inverse relationship that has been reported between DBS frequency and stimulus amplitude, required to alleviate PD motor symptoms [A. L. Benabid et al. (1991)Lancet, 337, 403–406]. The TC relay neuron selectively responded to and relayed synchronized GPi inputs bursting at a frequency located in the range 2–25 Hz. Input selectivity of the TC relay neuron is dictated by low‐threshold calcium current dynamics and passive membrane properties of the neuron. STN‐DBS prevented the TC relay neuron from relaying synchronized GPi oscillations to cortex. Our model indicates that DBS alters BG output and input selectivity of the TC relay neuron, providing an explanation for the clinically observed inverse relationship between DBS frequency and stimulus amplitude.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>19788577</pmid><doi>10.1111/j.1460-9568.2009.06922.x</doi><tpages>12</tpages><orcidid>https://orcid.org/0000-0002-8540-7808</orcidid><oa>free_for_read</oa></addata></record> |
fulltext | fulltext |
identifier | ISSN: 0953-816X |
ispartof | The European journal of neuroscience, 2009-10, Vol.30 (7), p.1306-1317 |
issn | 0953-816X 1460-9568 |
language | eng |
recordid | cdi_hal_primary_oai_HAL_hal_00586797v1 |
source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
subjects | Algorithms basal ganglia Brain Brain - physiopathology Calcium Calcium - metabolism Cerebral Cortex Cerebral Cortex - physiopathology Computer Simulation Deep Brain Stimulation Deep Brain Stimulation - methods Dendrites Dendrites - physiology Dyskinesias Dyskinesias - physiopathology Dyskinesias - therapy gamma-Aminobutyric Acid gamma-Aminobutyric Acid - metabolism Globus Pallidus Globus Pallidus - physiopathology high-frequency stimulation Humans Life Sciences Membrane Potentials Models, Neurological modulation Neural Pathways Neural Pathways - physiopathology Neurons Neurons - physiology Neurons and Cognition Parkinson Disease Parkinson Disease - physiopathology Parkinson Disease - therapy Periodicity relay Subthalamic Nucleus Subthalamic Nucleus - physiopathology |
title | Frequency-selectivity of a thalamocortical relay neuron during Parkinson's disease and deep brain stimulation: a computational study |
url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-30T23%3A56%3A41IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_hal_p&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Frequency-selectivity%20of%20a%20thalamocortical%20relay%20neuron%20during%20Parkinson's%20disease%20and%20deep%20brain%20stimulation:%20a%20computational%20study&rft.jtitle=The%20European%20journal%20of%20neuroscience&rft.au=Cagnan,%20Hayriye&rft.date=2009-10&rft.volume=30&rft.issue=7&rft.spage=1306&rft.epage=1317&rft.pages=1306-1317&rft.issn=0953-816X&rft.eissn=1460-9568&rft_id=info:doi/10.1111/j.1460-9568.2009.06922.x&rft_dat=%3Cproquest_hal_p%3E734075761%3C/proquest_hal_p%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=21149362&rft_id=info:pmid/19788577&rfr_iscdi=true |