The rate of decompensation and clinical progression of disease in people with cirrhosis: a cohort study
Aliment Pharmacol Ther 2010; 32: 1343–1350 Summary Background We lack population‐based estimates of the rate of decompensation in people with compensated cirrhosis as well as estimates of the manner in which the disease progresses once identified. Aim To determine the rate of decompensation and cl...
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| Veröffentlicht in: | Alimentary pharmacology & therapeutics 2010-12, Vol.32 (11‐12), p.1343-1350 |
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| creator | Fleming, K. M. Aithal, G. P. Card, T. R. West, J. |
| description | Aliment Pharmacol Ther 2010; 32: 1343–1350
Summary
Background We lack population‐based estimates of the rate of decompensation in people with compensated cirrhosis as well as estimates of the manner in which the disease progresses once identified.
Aim To determine the rate of decompensation and clinical progression of disease in patients with cirrhosis based upon clinical symptoms recorded electronically in general practice data.
Methods Using Cox proportional hazards regression, we modelled the rate of decompensation for patients from the UK General Practice Research Database with a diagnosis of cirrhosis between 1987 and 2002. We determined the clinical progression in the first year following diagnosis and subsequently categorizing patients through time according to a simple clinical staging system agreed at the Baveno IV consensus conference.
Results The rate of decompensation in patients with compensated cirrhosis was found to be 11% overall. The rate of decompensation was higher in the first year (at 31% compared with 7.3% afterwards) and in patients with an alcoholic aetiology. Patients with compensated cirrhosis had a 1‐year probability of proceeding directly to death of 7% compared with 20% in patients with decompensated cirrhosis.
Conclusions Using data recorded in general practice records, it is possible to determine the rate of decompensation and the clinical progression of disease in people with cirrhosis. |
| doi_str_mv | 10.1111/j.1365-2036.2010.04473.x |
| format | Article |
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Summary
Background We lack population‐based estimates of the rate of decompensation in people with compensated cirrhosis as well as estimates of the manner in which the disease progresses once identified.
Aim To determine the rate of decompensation and clinical progression of disease in patients with cirrhosis based upon clinical symptoms recorded electronically in general practice data.
Methods Using Cox proportional hazards regression, we modelled the rate of decompensation for patients from the UK General Practice Research Database with a diagnosis of cirrhosis between 1987 and 2002. We determined the clinical progression in the first year following diagnosis and subsequently categorizing patients through time according to a simple clinical staging system agreed at the Baveno IV consensus conference.
Results The rate of decompensation in patients with compensated cirrhosis was found to be 11% overall. The rate of decompensation was higher in the first year (at 31% compared with 7.3% afterwards) and in patients with an alcoholic aetiology. Patients with compensated cirrhosis had a 1‐year probability of proceeding directly to death of 7% compared with 20% in patients with decompensated cirrhosis.
Conclusions Using data recorded in general practice records, it is possible to determine the rate of decompensation and the clinical progression of disease in people with cirrhosis.</description><identifier>ISSN: 0269-2813</identifier><identifier>EISSN: 1365-2036</identifier><identifier>DOI: 10.1111/j.1365-2036.2010.04473.x</identifier><identifier>PMID: 21050236</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Adult ; Aged ; Biological and medical sciences ; Cohort Studies ; Digestive system ; Disease Progression ; Female ; Gastroenterology. Liver. Pancreas. Abdomen ; General Practice ; Humans ; Liver Cirrhosis - physiopathology ; Liver. Biliary tract. Portal circulation. Exocrine pancreas ; Male ; Medical sciences ; Middle Aged ; Other diseases. Semiology ; Pharmacology. Drug treatments ; Prognosis ; Regression Analysis ; Risk Factors ; Severity of Illness Index ; Survival Analysis ; Time Factors ; United Kingdom</subject><ispartof>Alimentary pharmacology & therapeutics, 2010-12, Vol.32 (11‐12), p.1343-1350</ispartof><rights>2010 Blackwell Publishing Ltd</rights><rights>2015 INIST-CNRS</rights><rights>2010 Blackwell Publishing Ltd.</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4823-de7159a60ea1c9fa981b38a8d0f896b57a052b5b4ffa9a16893bd546f4a16293</citedby><cites>FETCH-LOGICAL-c4823-de7159a60ea1c9fa981b38a8d0f896b57a052b5b4ffa9a16893bd546f4a16293</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1365-2036.2010.04473.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1365-2036.2010.04473.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,314,776,780,881,1411,1427,27903,27904,45553,45554,46387,46811</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23366557$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21050236$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.science/hal-00582718$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Fleming, K. M.</creatorcontrib><creatorcontrib>Aithal, G. P.</creatorcontrib><creatorcontrib>Card, T. R.</creatorcontrib><creatorcontrib>West, J.</creatorcontrib><title>The rate of decompensation and clinical progression of disease in people with cirrhosis: a cohort study</title><title>Alimentary pharmacology & therapeutics</title><addtitle>Aliment Pharmacol Ther</addtitle><description>Aliment Pharmacol Ther 2010; 32: 1343–1350
Summary
Background We lack population‐based estimates of the rate of decompensation in people with compensated cirrhosis as well as estimates of the manner in which the disease progresses once identified.
Aim To determine the rate of decompensation and clinical progression of disease in patients with cirrhosis based upon clinical symptoms recorded electronically in general practice data.
Methods Using Cox proportional hazards regression, we modelled the rate of decompensation for patients from the UK General Practice Research Database with a diagnosis of cirrhosis between 1987 and 2002. We determined the clinical progression in the first year following diagnosis and subsequently categorizing patients through time according to a simple clinical staging system agreed at the Baveno IV consensus conference.
Results The rate of decompensation in patients with compensated cirrhosis was found to be 11% overall. The rate of decompensation was higher in the first year (at 31% compared with 7.3% afterwards) and in patients with an alcoholic aetiology. Patients with compensated cirrhosis had a 1‐year probability of proceeding directly to death of 7% compared with 20% in patients with decompensated cirrhosis.
Conclusions Using data recorded in general practice records, it is possible to determine the rate of decompensation and the clinical progression of disease in people with cirrhosis.</description><subject>Adult</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Cohort Studies</subject><subject>Digestive system</subject><subject>Disease Progression</subject><subject>Female</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>General Practice</subject><subject>Humans</subject><subject>Liver Cirrhosis - physiopathology</subject><subject>Liver. Biliary tract. Portal circulation. Exocrine pancreas</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Other diseases. Semiology</subject><subject>Pharmacology. Drug treatments</subject><subject>Prognosis</subject><subject>Regression Analysis</subject><subject>Risk Factors</subject><subject>Severity of Illness Index</subject><subject>Survival Analysis</subject><subject>Time Factors</subject><subject>United Kingdom</subject><issn>0269-2813</issn><issn>1365-2036</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkU2P0zAQhi0EYsvCX0C-ILSHFH_EjoPEoVotLFIlOPRuTZzJ1lUaBzvd3f57HFrKFV_smfeZsT0vIZSzJc_r027JpVaFYFIvBctZVpaVXD6_IIuL8JIsmNB1IQyXV-RNSjvGmK6YeE2uBGeKCakX5GGzRRphQho62qIL-xGHBJMPA4Whpa73g3fQ0zGGh4gpzcKM-oSQkPqBjhjGHumTn7bU-Ri3Ifn0mQJ1YRviRNN0aI9vyasO-oTvzvs12Xy929zeF-sf377frtaFK42QRYsVVzVohsBd3UFteCMNmJZ1ptaNqoAp0aim7LIGXJtaNq0qdVfmQNTymtyc2m6ht2P0e4hHG8Db-9XazjnGlBEVN488sx9PbP7arwOmye59ctj3MGA4JFtpoU1ZMZ1JcyJdDClF7C6tObOzIXZn57nbee52NsT-McQ-59L350sOzR7bS-FfBzLw4QxAynPuIgzOp3-clForVWXuy4l78j0e__sBdvVzM5_kb-ywphA</recordid><startdate>201012</startdate><enddate>201012</enddate><creator>Fleming, K. M.</creator><creator>Aithal, G. P.</creator><creator>Card, T. R.</creator><creator>West, J.</creator><general>Blackwell Publishing Ltd</general><general>Blackwell</general><general>Wiley</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>1XC</scope><scope>VOOES</scope></search><sort><creationdate>201012</creationdate><title>The rate of decompensation and clinical progression of disease in people with cirrhosis: a cohort study</title><author>Fleming, K. M. ; Aithal, G. P. ; Card, T. R. ; West, J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4823-de7159a60ea1c9fa981b38a8d0f896b57a052b5b4ffa9a16893bd546f4a16293</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Cohort Studies</topic><topic>Digestive system</topic><topic>Disease Progression</topic><topic>Female</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>General Practice</topic><topic>Humans</topic><topic>Liver Cirrhosis - physiopathology</topic><topic>Liver. Biliary tract. Portal circulation. Exocrine pancreas</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Other diseases. Semiology</topic><topic>Pharmacology. Drug treatments</topic><topic>Prognosis</topic><topic>Regression Analysis</topic><topic>Risk Factors</topic><topic>Severity of Illness Index</topic><topic>Survival Analysis</topic><topic>Time Factors</topic><topic>United Kingdom</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fleming, K. M.</creatorcontrib><creatorcontrib>Aithal, G. P.</creatorcontrib><creatorcontrib>Card, T. R.</creatorcontrib><creatorcontrib>West, J.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><collection>Hyper Article en Ligne (HAL) (Open Access)</collection><jtitle>Alimentary pharmacology & therapeutics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fleming, K. M.</au><au>Aithal, G. P.</au><au>Card, T. R.</au><au>West, J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The rate of decompensation and clinical progression of disease in people with cirrhosis: a cohort study</atitle><jtitle>Alimentary pharmacology & therapeutics</jtitle><addtitle>Aliment Pharmacol Ther</addtitle><date>2010-12</date><risdate>2010</risdate><volume>32</volume><issue>11‐12</issue><spage>1343</spage><epage>1350</epage><pages>1343-1350</pages><issn>0269-2813</issn><eissn>1365-2036</eissn><abstract>Aliment Pharmacol Ther 2010; 32: 1343–1350
Summary
Background We lack population‐based estimates of the rate of decompensation in people with compensated cirrhosis as well as estimates of the manner in which the disease progresses once identified.
Aim To determine the rate of decompensation and clinical progression of disease in patients with cirrhosis based upon clinical symptoms recorded electronically in general practice data.
Methods Using Cox proportional hazards regression, we modelled the rate of decompensation for patients from the UK General Practice Research Database with a diagnosis of cirrhosis between 1987 and 2002. We determined the clinical progression in the first year following diagnosis and subsequently categorizing patients through time according to a simple clinical staging system agreed at the Baveno IV consensus conference.
Results The rate of decompensation in patients with compensated cirrhosis was found to be 11% overall. The rate of decompensation was higher in the first year (at 31% compared with 7.3% afterwards) and in patients with an alcoholic aetiology. Patients with compensated cirrhosis had a 1‐year probability of proceeding directly to death of 7% compared with 20% in patients with decompensated cirrhosis.
Conclusions Using data recorded in general practice records, it is possible to determine the rate of decompensation and the clinical progression of disease in people with cirrhosis.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>21050236</pmid><doi>10.1111/j.1365-2036.2010.04473.x</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Wiley Free Content |
| subjects | Adult Aged Biological and medical sciences Cohort Studies Digestive system Disease Progression Female Gastroenterology. Liver. Pancreas. Abdomen General Practice Humans Liver Cirrhosis - physiopathology Liver. Biliary tract. Portal circulation. Exocrine pancreas Male Medical sciences Middle Aged Other diseases. Semiology Pharmacology. Drug treatments Prognosis Regression Analysis Risk Factors Severity of Illness Index Survival Analysis Time Factors United Kingdom |
| title | The rate of decompensation and clinical progression of disease in people with cirrhosis: a cohort study |
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