Structure and kinetic characterization of human sperm-specific glyceraldehyde-3-phosphate dehydrogenase, GAPDS

hGAPDS (human sperm-specific glyceraldehyde-3-phosphate dehydrogenase) is a glycolytic enzyme essential for the survival of spermatozoa, and constitutes a potential target for non-hormonal contraception. However, enzyme characterization of GAPDS has been hampered by the difficulty in producing solub...

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Veröffentlicht in:	Biochemical journal 2011-04, Vol.435 (2), p.401-409
Hauptverfasser:	Chaikuad, Apirat, Shafqat, Naeem, Al-Mokhtar, Ruby, Cameron, Gus, Clarke, Anthony R, Brady, R Leo, Oppermann, Udo, Frayne, Jan, Yue, Wyatt W
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Binding Sites Catalysis Glyceraldehyde-3-Phosphate Dehydrogenases - chemistry Glyceraldehyde-3-Phosphate Dehydrogenases - genetics Glyceraldehyde-3-Phosphate Dehydrogenases - metabolism Humans Isoenzymes - chemistry Isoenzymes - metabolism Kinetics Male Models, Biological Models, Molecular Organ Specificity - genetics Phosphates - metabolism Protein Binding Protein Structure, Secondary Rats Spermatogenesis - genetics Spermatozoa - enzymology Spermatozoa - metabolism
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