Corneal collagen crosslinking in post-LASIK keratectasia
Background/aimsTo evaluate the effect of corneal collagen crosslinking with riboflavin and UV-A as a treatment option for postlaser in situ keratomileusis keratectasia.MethodsCrosslinking was carried out in 22 eyes of 15 patients with iatrogenic keratectasia. Follow-up, according to a standardised p...
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| Veröffentlicht in: | British journal of ophthalmology 2011-04, Vol.95 (4), p.493-497 |
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| creator | Salgado, J P Khoramnia, R Lohmann, C P Winkler von Mohrenfels, C |
| description | Background/aimsTo evaluate the effect of corneal collagen crosslinking with riboflavin and UV-A as a treatment option for postlaser in situ keratomileusis keratectasia.MethodsCrosslinking was carried out in 22 eyes of 15 patients with iatrogenic keratectasia. Follow-up, according to a standardised protocol (uncorrected visual acuity (UCVA), best-corrected visual acuity (BCVA), slit-lamp examination, pachymetry and topography), was performed preoperatively 1, 3, 6 and 12 months after crosslinking.ResultsThe mean BCVA was 0.19 (SD±0.21) logMAR preoperatively, 0.25 (SD±0.17) 1 month, 0.20 (SD±0.20) 3 months, 0.18 (SD±0.21) 6 months and 0.15 (SD±0.14) 12 months postoperatively (statistically significant postop1–postop6, p=0.0335). The maximum k-readings were 44.12 (SD±3.97) preoperatively, 46.23 (SD±4.14) 1 month, 43.88 (SD±4.25) 3 months, 45.06 (SD±5.07) 6 months and 44.43 (SD±4.06) 12 months postoperatively (statistically significant preop–postop1, p=0.0281).ConclusionCrosslinking in patients with iatrogenic keratectasia stabilised the UCVA and BCVA as well as the maximum k-readings in our cohort. It seems to be a safe and promising procedure to stabilise the refraction and the corneal topography, and thus to stop the progression of visual loss, thereby avoiding or delaying disease progression and keratoplasty. |
| doi_str_mv | 10.1136/bjo.2010.179424 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_hal_p</sourceid><recordid>TN_cdi_hal_primary_oai_HAL_hal_00577965v1</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>857814435</sourcerecordid><originalsourceid>FETCH-LOGICAL-b502t-7925a9c95143674e67443085adb36325a03367962e431bead85f84c23f2318643</originalsourceid><addsrcrecordid>eNqFkM9P2zAUx61paHTAmRuKNE3TJgX8_DvHqtoAkY3DOq6WkzrMbRoXO522_x6HlCJx2cGy3nsff_19X4ROAZ8DUHFRLf05wUMlC0bYGzQBJlROsCzeognGWOYAAg7R-xiXqSQC5Dt0SLCQBZZygtTMh86aNqt925p722V18DG2rlu57j5zXbbxsc_L6c_rm2xlg-lt3ZvozDE6aEwb7cnuPkK_vn2dz67y8vbyejYt84pj0ueyINwUdcGBUSGZTYdRrLhZVFTQNMM09QtBLKNQWbNQvFGsJrQhFJRg9Ah9HnV_m1Zvglub8E974_TVtNRDD2MukwD_A4n9NLKb4B-2NvZ67WJt02Kd9duoFZcK0v88kR9ekUu_DV1aRIOUashSDXoXI_WUSbDN3gBgPeSvU_56yF-P-acXZzvdbbW2iz3_HHgCPu4AE2vTNsF0tYsvHEti8GQwHzkXe_t3PzdhpYWkkusfdzOt5t_nUN7NdZn4LyNfrZf_dfkIiyqlGg</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1778942481</pqid></control><display><type>article</type><title>Corneal collagen crosslinking in post-LASIK keratectasia</title><source>MEDLINE</source><source>BMJ Journals - NESLi2</source><source>PubMed Central</source><creator>Salgado, J P ; Khoramnia, R ; Lohmann, C P ; Winkler von Mohrenfels, C</creator><creatorcontrib>Salgado, J P ; Khoramnia, R ; Lohmann, C P ; Winkler von Mohrenfels, C</creatorcontrib><description>Background/aimsTo evaluate the effect of corneal collagen crosslinking with riboflavin and UV-A as a treatment option for postlaser in situ keratomileusis keratectasia.MethodsCrosslinking was carried out in 22 eyes of 15 patients with iatrogenic keratectasia. Follow-up, according to a standardised protocol (uncorrected visual acuity (UCVA), best-corrected visual acuity (BCVA), slit-lamp examination, pachymetry and topography), was performed preoperatively 1, 3, 6 and 12 months after crosslinking.ResultsThe mean BCVA was 0.19 (SD±0.21) logMAR preoperatively, 0.25 (SD±0.17) 1 month, 0.20 (SD±0.20) 3 months, 0.18 (SD±0.21) 6 months and 0.15 (SD±0.14) 12 months postoperatively (statistically significant postop1–postop6, p=0.0335). The maximum k-readings were 44.12 (SD±3.97) preoperatively, 46.23 (SD±4.14) 1 month, 43.88 (SD±4.25) 3 months, 45.06 (SD±5.07) 6 months and 44.43 (SD±4.06) 12 months postoperatively (statistically significant preop–postop1, p=0.0281).ConclusionCrosslinking in patients with iatrogenic keratectasia stabilised the UCVA and BCVA as well as the maximum k-readings in our cohort. It seems to be a safe and promising procedure to stabilise the refraction and the corneal topography, and thus to stop the progression of visual loss, thereby avoiding or delaying disease progression and keratoplasty.</description><identifier>ISSN: 0007-1161</identifier><identifier>EISSN: 1468-2079</identifier><identifier>DOI: 10.1136/bjo.2010.179424</identifier><identifier>PMID: 20679077</identifier><identifier>CODEN: BJOPAL</identifier><language>eng</language><publisher>BMA House, Tavistock Square, London, WC1H 9JR: BMJ Publishing Group Ltd</publisher><subject>Adult ; Biological and medical sciences ; Collagen ; Collagen - therapeutic use ; Contact lenses ; cornea ; Corneal Diseases - drug therapy ; Cross-Linking Reagents - therapeutic use ; Crosslinking ; Female ; Humans ; keratectasia ; Keratomileusis, Laser In Situ - adverse effects ; Lasers ; LASIK ; Male ; Medical sciences ; Middle Aged ; Miscellaneous ; Myopia ; Myopia - physiopathology ; Myopia - therapy ; Ophthalmology ; Patients ; Photosensitizing Agents - therapeutic use ; Postoperative Period ; Prospective Studies ; Riboflavin - therapeutic use ; Surgery ; Topography ; Ultrasonic imaging ; Ultraviolet Therapy - methods ; Visual Acuity - physiology ; Vitamin B</subject><ispartof>British journal of ophthalmology, 2011-04, Vol.95 (4), p.493-497</ispartof><rights>2011, Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.</rights><rights>2015 INIST-CNRS</rights><rights>Copyright: 2011 (c) 2011, Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b502t-7925a9c95143674e67443085adb36325a03367962e431bead85f84c23f2318643</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttp://bjo.bmj.com/content/95/4/493.full.pdf$$EPDF$$P50$$Gbmj$$H</linktopdf><linktohtml>$$Uhttp://bjo.bmj.com/content/95/4/493.full$$EHTML$$P50$$Gbmj$$H</linktohtml><link.rule.ids>114,115,230,314,780,784,885,3196,23571,27924,27925,77600,77631</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24010135$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20679077$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.science/hal-00577965$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Salgado, J P</creatorcontrib><creatorcontrib>Khoramnia, R</creatorcontrib><creatorcontrib>Lohmann, C P</creatorcontrib><creatorcontrib>Winkler von Mohrenfels, C</creatorcontrib><title>Corneal collagen crosslinking in post-LASIK keratectasia</title><title>British journal of ophthalmology</title><addtitle>Br J Ophthalmol</addtitle><description>Background/aimsTo evaluate the effect of corneal collagen crosslinking with riboflavin and UV-A as a treatment option for postlaser in situ keratomileusis keratectasia.MethodsCrosslinking was carried out in 22 eyes of 15 patients with iatrogenic keratectasia. Follow-up, according to a standardised protocol (uncorrected visual acuity (UCVA), best-corrected visual acuity (BCVA), slit-lamp examination, pachymetry and topography), was performed preoperatively 1, 3, 6 and 12 months after crosslinking.ResultsThe mean BCVA was 0.19 (SD±0.21) logMAR preoperatively, 0.25 (SD±0.17) 1 month, 0.20 (SD±0.20) 3 months, 0.18 (SD±0.21) 6 months and 0.15 (SD±0.14) 12 months postoperatively (statistically significant postop1–postop6, p=0.0335). The maximum k-readings were 44.12 (SD±3.97) preoperatively, 46.23 (SD±4.14) 1 month, 43.88 (SD±4.25) 3 months, 45.06 (SD±5.07) 6 months and 44.43 (SD±4.06) 12 months postoperatively (statistically significant preop–postop1, p=0.0281).ConclusionCrosslinking in patients with iatrogenic keratectasia stabilised the UCVA and BCVA as well as the maximum k-readings in our cohort. It seems to be a safe and promising procedure to stabilise the refraction and the corneal topography, and thus to stop the progression of visual loss, thereby avoiding or delaying disease progression and keratoplasty.</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Collagen</subject><subject>Collagen - therapeutic use</subject><subject>Contact lenses</subject><subject>cornea</subject><subject>Corneal Diseases - drug therapy</subject><subject>Cross-Linking Reagents - therapeutic use</subject><subject>Crosslinking</subject><subject>Female</subject><subject>Humans</subject><subject>keratectasia</subject><subject>Keratomileusis, Laser In Situ - adverse effects</subject><subject>Lasers</subject><subject>LASIK</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Miscellaneous</subject><subject>Myopia</subject><subject>Myopia - physiopathology</subject><subject>Myopia - therapy</subject><subject>Ophthalmology</subject><subject>Patients</subject><subject>Photosensitizing Agents - therapeutic use</subject><subject>Postoperative Period</subject><subject>Prospective Studies</subject><subject>Riboflavin - therapeutic use</subject><subject>Surgery</subject><subject>Topography</subject><subject>Ultrasonic imaging</subject><subject>Ultraviolet Therapy - methods</subject><subject>Visual Acuity - physiology</subject><subject>Vitamin B</subject><issn>0007-1161</issn><issn>1468-2079</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNqFkM9P2zAUx61paHTAmRuKNE3TJgX8_DvHqtoAkY3DOq6WkzrMbRoXO522_x6HlCJx2cGy3nsff_19X4ROAZ8DUHFRLf05wUMlC0bYGzQBJlROsCzeognGWOYAAg7R-xiXqSQC5Dt0SLCQBZZygtTMh86aNqt925p722V18DG2rlu57j5zXbbxsc_L6c_rm2xlg-lt3ZvozDE6aEwb7cnuPkK_vn2dz67y8vbyejYt84pj0ueyINwUdcGBUSGZTYdRrLhZVFTQNMM09QtBLKNQWbNQvFGsJrQhFJRg9Ah9HnV_m1Zvglub8E974_TVtNRDD2MukwD_A4n9NLKb4B-2NvZ67WJt02Kd9duoFZcK0v88kR9ekUu_DV1aRIOUashSDXoXI_WUSbDN3gBgPeSvU_56yF-P-acXZzvdbbW2iz3_HHgCPu4AE2vTNsF0tYsvHEti8GQwHzkXe_t3PzdhpYWkkusfdzOt5t_nUN7NdZn4LyNfrZf_dfkIiyqlGg</recordid><startdate>20110401</startdate><enddate>20110401</enddate><creator>Salgado, J P</creator><creator>Khoramnia, R</creator><creator>Lohmann, C P</creator><creator>Winkler von Mohrenfels, C</creator><general>BMJ Publishing Group Ltd</general><general>BMJ Publishing Group</general><general>BMJ Publishing Group LTD</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>1XC</scope><scope>VOOES</scope></search><sort><creationdate>20110401</creationdate><title>Corneal collagen crosslinking in post-LASIK keratectasia</title><author>Salgado, J P ; Khoramnia, R ; Lohmann, C P ; Winkler von Mohrenfels, C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b502t-7925a9c95143674e67443085adb36325a03367962e431bead85f84c23f2318643</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Collagen</topic><topic>Collagen - therapeutic use</topic><topic>Contact lenses</topic><topic>cornea</topic><topic>Corneal Diseases - drug therapy</topic><topic>Cross-Linking Reagents - therapeutic use</topic><topic>Crosslinking</topic><topic>Female</topic><topic>Humans</topic><topic>keratectasia</topic><topic>Keratomileusis, Laser In Situ - adverse effects</topic><topic>Lasers</topic><topic>LASIK</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Miscellaneous</topic><topic>Myopia</topic><topic>Myopia - physiopathology</topic><topic>Myopia - therapy</topic><topic>Ophthalmology</topic><topic>Patients</topic><topic>Photosensitizing Agents - therapeutic use</topic><topic>Postoperative Period</topic><topic>Prospective Studies</topic><topic>Riboflavin - therapeutic use</topic><topic>Surgery</topic><topic>Topography</topic><topic>Ultrasonic imaging</topic><topic>Ultraviolet Therapy - methods</topic><topic>Visual Acuity - physiology</topic><topic>Vitamin B</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Salgado, J P</creatorcontrib><creatorcontrib>Khoramnia, R</creatorcontrib><creatorcontrib>Lohmann, C P</creatorcontrib><creatorcontrib>Winkler von Mohrenfels, C</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><collection>Hyper Article en Ligne (HAL) (Open Access)</collection><jtitle>British journal of ophthalmology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Salgado, J P</au><au>Khoramnia, R</au><au>Lohmann, C P</au><au>Winkler von Mohrenfels, C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Corneal collagen crosslinking in post-LASIK keratectasia</atitle><jtitle>British journal of ophthalmology</jtitle><addtitle>Br J Ophthalmol</addtitle><date>2011-04-01</date><risdate>2011</risdate><volume>95</volume><issue>4</issue><spage>493</spage><epage>497</epage><pages>493-497</pages><issn>0007-1161</issn><eissn>1468-2079</eissn><coden>BJOPAL</coden><abstract>Background/aimsTo evaluate the effect of corneal collagen crosslinking with riboflavin and UV-A as a treatment option for postlaser in situ keratomileusis keratectasia.MethodsCrosslinking was carried out in 22 eyes of 15 patients with iatrogenic keratectasia. Follow-up, according to a standardised protocol (uncorrected visual acuity (UCVA), best-corrected visual acuity (BCVA), slit-lamp examination, pachymetry and topography), was performed preoperatively 1, 3, 6 and 12 months after crosslinking.ResultsThe mean BCVA was 0.19 (SD±0.21) logMAR preoperatively, 0.25 (SD±0.17) 1 month, 0.20 (SD±0.20) 3 months, 0.18 (SD±0.21) 6 months and 0.15 (SD±0.14) 12 months postoperatively (statistically significant postop1–postop6, p=0.0335). The maximum k-readings were 44.12 (SD±3.97) preoperatively, 46.23 (SD±4.14) 1 month, 43.88 (SD±4.25) 3 months, 45.06 (SD±5.07) 6 months and 44.43 (SD±4.06) 12 months postoperatively (statistically significant preop–postop1, p=0.0281).ConclusionCrosslinking in patients with iatrogenic keratectasia stabilised the UCVA and BCVA as well as the maximum k-readings in our cohort. It seems to be a safe and promising procedure to stabilise the refraction and the corneal topography, and thus to stop the progression of visual loss, thereby avoiding or delaying disease progression and keratoplasty.</abstract><cop>BMA House, Tavistock Square, London, WC1H 9JR</cop><pub>BMJ Publishing Group Ltd</pub><pmid>20679077</pmid><doi>10.1136/bjo.2010.179424</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Biological and medical sciences Collagen Collagen - therapeutic use Contact lenses cornea Corneal Diseases - drug therapy Cross-Linking Reagents - therapeutic use Crosslinking Female Humans keratectasia Keratomileusis, Laser In Situ - adverse effects Lasers LASIK Male Medical sciences Middle Aged Miscellaneous Myopia Myopia - physiopathology Myopia - therapy Ophthalmology Patients Photosensitizing Agents - therapeutic use Postoperative Period Prospective Studies Riboflavin - therapeutic use Surgery Topography Ultrasonic imaging Ultraviolet Therapy - methods Visual Acuity - physiology Vitamin B |
| title | Corneal collagen crosslinking in post-LASIK keratectasia |
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