Layer-specific activity of tissue non-specific alkaline phosphatase in the human neocortex

Abstract The ectoenzyme tissue non-specific alkaline phosphatase (TNAP) is mostly known for its role in bone mineralization. However, in the severe form of hypophosphatasia, TNAP deficiency also results in epileptic seizures, suggesting a role of this enzyme in brain functions. Accordingly, TNAP act...

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Veröffentlicht in:	Neuroscience 2011-01, Vol.172 (1), p.406-418
Hauptverfasser:	Négyessy, L, Xiao, J, Kántor, O, Kovács, G.G, Palkovits, M, Dóczi, T.P, Renaud, L, Baksa, G, Glasz, T, Ashaber, M, Barone, P, Fonta, C
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Afferent Pathways - cytology Afferent Pathways - enzymology Aged Alkaline Phosphatase - metabolism Alkaline Phosphatase - physiology Alzheimer disease B6-dependent enzymes Biological and medical sciences Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases epilepsy Female Frontal Lobe - cytology Frontal Lobe - enzymology Fundamental and applied biological sciences. Psychology Humans hypophosphatasia layer 5 Life Sciences Male Medical sciences Middle Aged Neocortex - cytology Neocortex - enzymology Neurology Neurons - cytology Neurons - enzymology Neurons and Cognition neurotransmitter Occipital Lobe - cytology Occipital Lobe - enzymology Somatosensory Cortex - cytology Somatosensory Cortex - enzymology Temporal Lobe - cytology Temporal Lobe - enzymology Thalamus - cytology Thalamus - enzymology Vertebrates: nervous system and sense organs Visual Cortex - cytology Visual Cortex - enzymology
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