Synthesis and investigation of inhibition effect of fluorinated sulfonamide derivatives on carbonic anhydrase

Synthesis and investigation of inhibition effect of fluorinated sulfonamide derivatives on carbonic anhydrase

Series of perfluoroalkanesulfonamides 1, sodium salt of perfluoroalkanesulfonamides 2 and polyfluoroalkanesulfonamides 3 derivatives were synthesized and characterized by 1H NMR, 13C NMR, 19F NMR, IR and HRMS. Inhibition effects of these compounds on bovine carbonic anhydrase (bCA) and human carboni...

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Veröffentlicht in:European journal of medicinal chemistry 2010, Vol.45 (3), p.1225-1229
Hauptverfasser: Benfodda, Zohra, Guillen, Franck, Romestand, Bernard, Dahmani, Abdelkader, Blancou, Hubert
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Organic chemistry
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container_issue 3
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container_title European journal of medicinal chemistry
container_volume 45
creator Benfodda, Zohra
Guillen, Franck
Romestand, Bernard
Dahmani, Abdelkader
Blancou, Hubert
description Series of perfluoroalkanesulfonamides 1, sodium salt of perfluoroalkanesulfonamides 2 and polyfluoroalkanesulfonamides 3 derivatives were synthesized and characterized by 1H NMR, 13C NMR, 19F NMR, IR and HRMS. Inhibition effects of these compounds on bovine carbonic anhydrase (bCA) and human carbonic anhydrase isoenzyme II (hCA) have been investigated. Comparing IC50 values of the synthesized molecules 1, 2 and 3, it has been found that compound 2b is a more potent inhibitor than acetazolamide on hCA. Moreover 2b does not present cellular toxicity on sheep red globules.
doi_str_mv 10.1016/j.ejmrech2009.11.052
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Organic chemistry
title Synthesis and investigation of inhibition effect of fluorinated sulfonamide derivatives on carbonic anhydrase
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