A continuum receptor model of hepatic lipoprotein metabolism

A mathematical model describing the uptake of low density lipoprotein (LDL) and very low density lipoprotein (VLDL) particles by a single hepatocyte cell is formulated and solved. The model includes a description of the dynamic change in receptor density on the surface of the cell due to the binding...

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Veröffentlicht in:	Journal of theoretical biology 2009-04, Vol.257 (3), p.371-384
Hauptverfasser:	Tindall, M.J., Wattis, J.A.D., O’Malley, B.J., Pickersgill, L., Jackson, K.G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apolipoprotein E (ApoE) Apolipoproteins E - metabolism Binding, Competitive Cholesterol Cholesterol - metabolism Endocytosis Endocytosis - physiology Hepatocytes - metabolism Lipoproteins, LDL - metabolism Lipoproteins, VLDL - metabolism Low density lipoprotein (LDL) Models, Biological Receptors, LDL - metabolism Triglyceride rich lipoprotein (TRL) Very low density lipoprotein (VLDL)
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