The existence of a relationship between increased serum alanine aminotransferase levels detected in premarketing clinical trials and postmarketing published hepatotoxicity case reports

Aliment Pharmacol Ther 31, 1337–1345 Summary Background Drug‐induced liver injury (DILI) profile in most drugs’ available information is based on both the incidence of alanine aminotansferase (ALT) elevations in clinical trials and published case reports. Aim To assess the relationship between ALT...

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Veröffentlicht in:	Alimentary pharmacology & therapeutics 2010-06, Vol.31 (12), p.1337-1345
Hauptverfasser:	LLANOS, L., MOREU, R., ORTIN, T., PEIRÓ, A. M., PASCUAL, S., BELLOT, P., BARQUERO, C., FRANCÉS, R., SUCH, J., PÉREZ‐MATEO, M., HORGA, J. F., ZAPATER, P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alanine Alanine transaminase Alanine Transaminase - blood Biological and medical sciences Biomarkers - blood Black boxes Case reports Chemical and Drug Induced Liver Injury - enzymology Clinical trials Clinical Trials as Topic Digestive system Drug Labeling Drugs Gastroenterology. Liver. Pancreas. Abdomen Hepatotoxicity Humans Incidence Labeling Liver Medical sciences Periodicals as Topic Pharmacology. Drug treatments Product Surveillance, Postmarketing Publication Bias Safety-Based Drug Withdrawals
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