Tax ubiquitylation and SUMOylation control the dynamic shuttling of Tax and NEMO between Ubc9 nuclear bodies and the centrosome

The human T-lymphotropic virus type I oncoprotein Tax is critical for T-cell transformation, acting mainly through nuclear factor kappa B essential modulator (NEMO) binding and subsequent nuclear factor-κB activation. Tax localizes to Tax nuclear bodies and to the centrosome and is subjected to ubiq...

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Veröffentlicht in:	Blood 2011-01, Vol.117 (1), p.190-199
Hauptverfasser:	Kfoury, Youmna, Setterblad, Niclas, El-Sabban, Marwan, Zamborlini, Alessia, Dassouki, Zeina, El Hajj, Hiba, Hermine, Olivier, Pique, Claudine, de Thé, Hugues, Saïb, Ali, Bazarbachi, Ali
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Blood Blotting, Western Cell Nucleus - metabolism Cells, Cultured Centrosome - physiology Cytoplasm - metabolism Embryo, Mammalian - cytology Embryo, Mammalian - metabolism Fibroblasts - cytology Fibroblasts - metabolism Fluorescent Antibody Technique Gene Products, tax - physiology Hematologic and hematopoietic diseases Hematology Human health and pathology Human T-lymphotropic virus Humans I-kappa B Kinase - genetics I-kappa B Kinase - metabolism Kidney - cytology Kidney - metabolism Life Sciences Lung - cytology Lung - metabolism Medical sciences NF-kappa B - genetics NF-kappa B - metabolism Protein Binding Protein Processing, Post-Translational Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - genetics Signal Transduction Sumoylation Transcriptional Activation Ubiquitin - metabolism Ubiquitin-Conjugating Enzymes - genetics Ubiquitin-Conjugating Enzymes - metabolism Ubiquitination
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