Characterization of angiogenin receptors on bovine brain capillary endothelial cells
The mitogenic effect of bovine milk angiogenin was studied on bovine brain capillary and aortic endothelial cells, smooth muscle cells and fibroblasts. The proliferation of only bovine brain capillary endothelial cells was detected at concentrations ranging from 10 to 1,000 ng/ml, with a maximum eff...
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| Veröffentlicht in: | Biochemical and biophysical research communications 1991-04, Vol.176 (2), p.833-839 |
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| container_title | Biochemical and biophysical research communications |
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| creator | Chamoux, M. Dehouck, M.P. Fruchart, J.C. Spik, G. Montreuil, J. Cecchelli, R. |
| description | The mitogenic effect of bovine milk angiogenin was studied on bovine brain capillary and aortic endothelial cells, smooth muscle cells and fibroblasts. The proliferation of only bovine brain capillary endothelial cells was detected at concentrations ranging from 10 to 1,000 ng/ml, with a maximum effect at 100ng/ml. This mitogenic activity may be correlated with a specific binding of angiogenin which was demonstrated only to bovine brain capillary endothelial cells. [
125I]-labeled angiogenin binding was time and concentration dependent and saturable. Scatchard analyses of binding data showed evidence of a single class of binding sites with an apparent dissociation constant of 5.10
−10 M. The molecular mass of the angiogenin receptor (49 kDa) was determined by ligand blotting. |
| doi_str_mv | 10.1016/S0006-291X(05)80261-X |
| format | Article |
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125I]-labeled angiogenin binding was time and concentration dependent and saturable. Scatchard analyses of binding data showed evidence of a single class of binding sites with an apparent dissociation constant of 5.10
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125I]-labeled angiogenin binding was time and concentration dependent and saturable. Scatchard analyses of binding data showed evidence of a single class of binding sites with an apparent dissociation constant of 5.10
−10 M. The molecular mass of the angiogenin receptor (49 kDa) was determined by ligand blotting.</description><subject>Animals</subject><subject>Binding Sites</subject><subject>Biochemistry, Molecular Biology</subject><subject>Biological and medical sciences</subject><subject>brain</subject><subject>Brain - blood supply</subject><subject>Brain - metabolism</subject><subject>capillaries</subject><subject>Capillaries - metabolism</subject><subject>Cattle</subject><subject>Cell receptors</subject><subject>Cell structures and functions</subject><subject>Cells, Cultured</subject><subject>Fundamental and applied biological sciences. 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The proliferation of only bovine brain capillary endothelial cells was detected at concentrations ranging from 10 to 1,000 ng/ml, with a maximum effect at 100ng/ml. This mitogenic activity may be correlated with a specific binding of angiogenin which was demonstrated only to bovine brain capillary endothelial cells. [
125I]-labeled angiogenin binding was time and concentration dependent and saturable. Scatchard analyses of binding data showed evidence of a single class of binding sites with an apparent dissociation constant of 5.10
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| source | Elsevier ScienceDirect Journals Complete - AutoHoldings; MEDLINE |
| subjects | Animals Binding Sites Biochemistry, Molecular Biology Biological and medical sciences brain Brain - blood supply Brain - metabolism capillaries Capillaries - metabolism Cattle Cell receptors Cell structures and functions Cells, Cultured Fundamental and applied biological sciences. Psychology Life Sciences Ligands Miscellaneous Molecular and cellular biology Muscle, Smooth, Vascular - metabolism Proteins - metabolism Ribonuclease, Pancreatic |
| title | Characterization of angiogenin receptors on bovine brain capillary endothelial cells |
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