Increased risk of contralateral breast cancers among overweight and obese women: a time-dependent association
Breast cancer (BC) survivors are at increased risk of second cancers. Obesity is commonly recognized as a risk factor of BC in postmenopausal period and a prognosis factor in BC regardless of menopausal status. Our aim was to study whether overweight BC survivors were at increased risk of contralate...
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| Veröffentlicht in: | Breast cancer research and treatment 2011-04, Vol.126 (3), p.729-738 |
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| creator | Majed, Bilal Dozol, Adrien Ribassin-Majed, Laureen Senouci, Kamel Asselain, Bernard |
| description | Breast cancer (BC) survivors are at increased risk of second cancers. Obesity is commonly recognized as a risk factor of BC in postmenopausal period and a prognosis factor in BC regardless of menopausal status. Our aim was to study whether overweight BC survivors were at increased risk of contralateral BC (CBC). Our population was a large cohort of women followed since a first BC without distant spread and/or synchronous CBC. Body mass index (BMI) was assessed at diagnosis time. Binary codings of BMI were used to oppose overweight and obese patients to the others. Survival analyses were used including Cox models. Assumed hypothesis of proportional hazards was explored using graphical methods, Schoenfeld residuals and time-dependant covariates. In case of non-proportional hazards, survival models were computed over time periods. Over 15,000 patients were included in our study. Incidence of CBC was 8.8 (8.3–9.3)/1000 person-years and increased during follow-up. A significant time-dependent association between overweight and CBC was observed. After 10 years of follow-up, we found a significant increased hazard of CBC among patients with a BMI above 25 kg/m
2
: the adjusted hazard ratio was 1.50(1.21–1.86),
P
= 0.001. After 10 years of follow-up, our study found a poorer prognosis among overweight BC survivors regarding CBC events. While benefits from diet habits and weight control may be expected during the long-term follow-up, they have yet to be established using randomized clinical trials. |
| doi_str_mv | 10.1007/s10549-010-1153-z |
| format | Article |
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2
: the adjusted hazard ratio was 1.50(1.21–1.86),
P
= 0.001. After 10 years of follow-up, our study found a poorer prognosis among overweight BC survivors regarding CBC events. While benefits from diet habits and weight control may be expected during the long-term follow-up, they have yet to be established using randomized clinical trials.</description><identifier>ISSN: 0167-6806</identifier><identifier>EISSN: 1573-7217</identifier><identifier>DOI: 10.1007/s10549-010-1153-z</identifier><identifier>PMID: 20872242</identifier><identifier>CODEN: BCTRD6</identifier><language>eng</language><publisher>Boston: Springer US</publisher><subject>Adolescent ; Adult ; Aged ; Aged, 80 and over ; Applications ; Biological and medical sciences ; Body Mass Index ; Breast cancer ; Breast Neoplasms - diagnosis ; Breast Neoplasms - pathology ; Breast Neoplasms - secondary ; Cancer ; Cancer research ; Cancer therapies ; Cohort Studies ; Epidemiology ; Female ; Follow-Up Studies ; Gynecology. Andrology. Obstetrics ; Humans ; Life Sciences ; Mammary gland diseases ; Medical prognosis ; Medical sciences ; Medicine ; Medicine & Public Health ; Menopause ; Metabolic diseases ; Middle Aged ; Neoplasms, Second Primary - diagnosis ; Neoplasms, Second Primary - pathology ; Obesity ; Obesity - complications ; Obesity - pathology ; Oncology ; Overweight ; Postmenopausal women ; Prognosis ; Proportional Hazards Models ; Risk ; Risk factors ; Statistics ; Time Factors ; Tumors</subject><ispartof>Breast cancer research and treatment, 2011-04, Vol.126 (3), p.729-738</ispartof><rights>Springer Science+Business Media, LLC. 2010</rights><rights>2015 INIST-CNRS</rights><rights>COPYRIGHT 2011 Springer</rights><rights>Springer Science+Business Media, LLC. 2011</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c641t-c4d1456d972d46d71be09011d2cf957aa0266716e1224ea344d9707ff876a4573</citedby><cites>FETCH-LOGICAL-c641t-c4d1456d972d46d71be09011d2cf957aa0266716e1224ea344d9707ff876a4573</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10549-010-1153-z$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10549-010-1153-z$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>230,314,776,780,881,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23982095$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20872242$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.science/hal-00523454$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Majed, Bilal</creatorcontrib><creatorcontrib>Dozol, Adrien</creatorcontrib><creatorcontrib>Ribassin-Majed, Laureen</creatorcontrib><creatorcontrib>Senouci, Kamel</creatorcontrib><creatorcontrib>Asselain, Bernard</creatorcontrib><title>Increased risk of contralateral breast cancers among overweight and obese women: a time-dependent association</title><title>Breast cancer research and treatment</title><addtitle>Breast Cancer Res Treat</addtitle><addtitle>Breast Cancer Res Treat</addtitle><description>Breast cancer (BC) survivors are at increased risk of second cancers. Obesity is commonly recognized as a risk factor of BC in postmenopausal period and a prognosis factor in BC regardless of menopausal status. Our aim was to study whether overweight BC survivors were at increased risk of contralateral BC (CBC). Our population was a large cohort of women followed since a first BC without distant spread and/or synchronous CBC. Body mass index (BMI) was assessed at diagnosis time. Binary codings of BMI were used to oppose overweight and obese patients to the others. Survival analyses were used including Cox models. Assumed hypothesis of proportional hazards was explored using graphical methods, Schoenfeld residuals and time-dependant covariates. In case of non-proportional hazards, survival models were computed over time periods. Over 15,000 patients were included in our study. Incidence of CBC was 8.8 (8.3–9.3)/1000 person-years and increased during follow-up. A significant time-dependent association between overweight and CBC was observed. After 10 years of follow-up, we found a significant increased hazard of CBC among patients with a BMI above 25 kg/m
2
: the adjusted hazard ratio was 1.50(1.21–1.86),
P
= 0.001. After 10 years of follow-up, our study found a poorer prognosis among overweight BC survivors regarding CBC events. While benefits from diet habits and weight control may be expected during the long-term follow-up, they have yet to be established using randomized clinical trials.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Applications</subject><subject>Biological and medical sciences</subject><subject>Body Mass Index</subject><subject>Breast cancer</subject><subject>Breast Neoplasms - diagnosis</subject><subject>Breast Neoplasms - pathology</subject><subject>Breast Neoplasms - secondary</subject><subject>Cancer</subject><subject>Cancer research</subject><subject>Cancer therapies</subject><subject>Cohort Studies</subject><subject>Epidemiology</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Gynecology. Andrology. 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Obesity is commonly recognized as a risk factor of BC in postmenopausal period and a prognosis factor in BC regardless of menopausal status. Our aim was to study whether overweight BC survivors were at increased risk of contralateral BC (CBC). Our population was a large cohort of women followed since a first BC without distant spread and/or synchronous CBC. Body mass index (BMI) was assessed at diagnosis time. Binary codings of BMI were used to oppose overweight and obese patients to the others. Survival analyses were used including Cox models. Assumed hypothesis of proportional hazards was explored using graphical methods, Schoenfeld residuals and time-dependant covariates. In case of non-proportional hazards, survival models were computed over time periods. Over 15,000 patients were included in our study. Incidence of CBC was 8.8 (8.3–9.3)/1000 person-years and increased during follow-up. A significant time-dependent association between overweight and CBC was observed. After 10 years of follow-up, we found a significant increased hazard of CBC among patients with a BMI above 25 kg/m
2
: the adjusted hazard ratio was 1.50(1.21–1.86),
P
= 0.001. After 10 years of follow-up, our study found a poorer prognosis among overweight BC survivors regarding CBC events. While benefits from diet habits and weight control may be expected during the long-term follow-up, they have yet to be established using randomized clinical trials.</abstract><cop>Boston</cop><pub>Springer US</pub><pmid>20872242</pmid><doi>10.1007/s10549-010-1153-z</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Breast cancer research and treatment, 2011-04, Vol.126 (3), p.729-738 |
| issn | 0167-6806 1573-7217 |
| language | eng |
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| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Adolescent Adult Aged Aged, 80 and over Applications Biological and medical sciences Body Mass Index Breast cancer Breast Neoplasms - diagnosis Breast Neoplasms - pathology Breast Neoplasms - secondary Cancer Cancer research Cancer therapies Cohort Studies Epidemiology Female Follow-Up Studies Gynecology. Andrology. Obstetrics Humans Life Sciences Mammary gland diseases Medical prognosis Medical sciences Medicine Medicine & Public Health Menopause Metabolic diseases Middle Aged Neoplasms, Second Primary - diagnosis Neoplasms, Second Primary - pathology Obesity Obesity - complications Obesity - pathology Oncology Overweight Postmenopausal women Prognosis Proportional Hazards Models Risk Risk factors Statistics Time Factors Tumors |
| title | Increased risk of contralateral breast cancers among overweight and obese women: a time-dependent association |
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