Biphasic Calcium Phosphate Microparticles for Bone Formation: Benefits of Combination with Blood Clot
Particulate forms of biphasic calcium phosphate (BCP) biomaterials below 500 μm are promising bone substitutes that provide with interconnected open porosity allowing free circulation of fluids and cells. Dispersion of the particles in the surrounding tissues at the time of implantation is a major d...
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| Veröffentlicht in: | Tissue engineering. Part A 2010-11, Vol.16 (11), p.3495-3505 |
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| creator | Balaguer, Thierry Boukhechba, Florian Clavé, Arnaud Bouvet-Gerbettaz, Sébastien Trojani, Christophe Michiels, Jean-François Laugier, Jean-Pierre Bouler, Jean-Michel Carle, Georges F. Scimeca, Jean-Claude Rochet, Nathalie |
| description | Particulate forms of biphasic calcium phosphate (BCP) biomaterials below 500 μm are promising bone substitutes that provide with interconnected open porosity allowing free circulation of fluids and cells. Dispersion of the particles in the surrounding tissues at the time of implantation is a major drawback preventing from an easy use. We have asked whether blood clot could be a convenient natural hydrogel for handling BCP microparticles, and we hypothesized that blood clot might also confer osteoinductive properties to these particles. We show here that blood clotted around BCP microparticles constitutes a cohesive, moldable, and adaptable biomaterial that can be easily implanted in subcutaneous sites but also inserted and maintained in segmental bone defects, conversely to BCP microparticles alone. Moreover, implantation in bony and ectopic sites revealed that this composite biomaterial has osteogenic properties. It is able to repair a 6-mm critical femoral defect in rat and induced woven bone formation after subcutaneous implantation. Parameters such as particle size and loading into the clot are critical for its osteogenic properties. In conclusion, this blood/BCP microparticle composite is a moldable and osteoinductive biomaterial that could be used for bone defect filling in dental and orthopedic surgery. |
| doi_str_mv | 10.1089/ten.tea.2010.0227 |
| format | Article |
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Dispersion of the particles in the surrounding tissues at the time of implantation is a major drawback preventing from an easy use. We have asked whether blood clot could be a convenient natural hydrogel for handling BCP microparticles, and we hypothesized that blood clot might also confer osteoinductive properties to these particles. We show here that blood clotted around BCP microparticles constitutes a cohesive, moldable, and adaptable biomaterial that can be easily implanted in subcutaneous sites but also inserted and maintained in segmental bone defects, conversely to BCP microparticles alone. Moreover, implantation in bony and ectopic sites revealed that this composite biomaterial has osteogenic properties. It is able to repair a 6-mm critical femoral defect in rat and induced woven bone formation after subcutaneous implantation. Parameters such as particle size and loading into the clot are critical for its osteogenic properties. In conclusion, this blood/BCP microparticle composite is a moldable and osteoinductive biomaterial that could be used for bone defect filling in dental and orthopedic surgery.</description><identifier>ISSN: 1937-3341</identifier><identifier>EISSN: 1937-335X</identifier><identifier>DOI: 10.1089/ten.tea.2010.0227</identifier><identifier>PMID: 20590522</identifier><language>eng</language><publisher>United States: Mary Ann Liebert, Inc</publisher><subject>Animals ; Biochemistry, Molecular Biology ; Biomedical materials ; Blood Cells - drug effects ; Blood Cells - metabolism ; Blood clot ; Blood clots ; Blood Coagulation - drug effects ; Bones ; Calcium phosphate ; Calcium phosphates ; Calcium Phosphates - chemistry ; Calcium Phosphates - pharmacology ; Cellular biology ; Feasibility Studies ; Femur - diagnostic imaging ; Femur - drug effects ; Femur - pathology ; Growth ; Health aspects ; Life Sciences ; Mice ; Original Articles ; Osteogenesis - drug effects ; Particle Size ; Prosthesis Implantation ; Radiography ; Rats ; Subcutaneous Tissue - drug effects ; Thrombosis ; Tissue engineering</subject><ispartof>Tissue engineering. 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Part A</title><addtitle>Tissue Eng Part A</addtitle><description>Particulate forms of biphasic calcium phosphate (BCP) biomaterials below 500 μm are promising bone substitutes that provide with interconnected open porosity allowing free circulation of fluids and cells. Dispersion of the particles in the surrounding tissues at the time of implantation is a major drawback preventing from an easy use. We have asked whether blood clot could be a convenient natural hydrogel for handling BCP microparticles, and we hypothesized that blood clot might also confer osteoinductive properties to these particles. We show here that blood clotted around BCP microparticles constitutes a cohesive, moldable, and adaptable biomaterial that can be easily implanted in subcutaneous sites but also inserted and maintained in segmental bone defects, conversely to BCP microparticles alone. Moreover, implantation in bony and ectopic sites revealed that this composite biomaterial has osteogenic properties. 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Part A</jtitle><addtitle>Tissue Eng Part A</addtitle><date>2010-11-01</date><risdate>2010</risdate><volume>16</volume><issue>11</issue><spage>3495</spage><epage>3505</epage><pages>3495-3505</pages><issn>1937-3341</issn><eissn>1937-335X</eissn><abstract>Particulate forms of biphasic calcium phosphate (BCP) biomaterials below 500 μm are promising bone substitutes that provide with interconnected open porosity allowing free circulation of fluids and cells. Dispersion of the particles in the surrounding tissues at the time of implantation is a major drawback preventing from an easy use. We have asked whether blood clot could be a convenient natural hydrogel for handling BCP microparticles, and we hypothesized that blood clot might also confer osteoinductive properties to these particles. We show here that blood clotted around BCP microparticles constitutes a cohesive, moldable, and adaptable biomaterial that can be easily implanted in subcutaneous sites but also inserted and maintained in segmental bone defects, conversely to BCP microparticles alone. Moreover, implantation in bony and ectopic sites revealed that this composite biomaterial has osteogenic properties. It is able to repair a 6-mm critical femoral defect in rat and induced woven bone formation after subcutaneous implantation. Parameters such as particle size and loading into the clot are critical for its osteogenic properties. In conclusion, this blood/BCP microparticle composite is a moldable and osteoinductive biomaterial that could be used for bone defect filling in dental and orthopedic surgery.</abstract><cop>United States</cop><pub>Mary Ann Liebert, Inc</pub><pmid>20590522</pmid><doi>10.1089/ten.tea.2010.0227</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0001-9784-5584</orcidid><orcidid>https://orcid.org/0000-0002-3901-1052</orcidid><orcidid>https://orcid.org/0000-0003-3773-6110</orcidid></addata></record> |
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| ispartof | Tissue engineering. Part A, 2010-11, Vol.16 (11), p.3495-3505 |
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| source | Mary Ann Liebert Online Subscription; MEDLINE; Alma/SFX Local Collection |
| subjects | Animals Biochemistry, Molecular Biology Biomedical materials Blood Cells - drug effects Blood Cells - metabolism Blood clot Blood clots Blood Coagulation - drug effects Bones Calcium phosphate Calcium phosphates Calcium Phosphates - chemistry Calcium Phosphates - pharmacology Cellular biology Feasibility Studies Femur - diagnostic imaging Femur - drug effects Femur - pathology Growth Health aspects Life Sciences Mice Original Articles Osteogenesis - drug effects Particle Size Prosthesis Implantation Radiography Rats Subcutaneous Tissue - drug effects Thrombosis Tissue engineering |
| title | Biphasic Calcium Phosphate Microparticles for Bone Formation: Benefits of Combination with Blood Clot |
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