Heat shock protein gp96 and NAD(P)H oxidase 4 play key roles in Toll-like receptor 4-activated apoptosis during renal ischemia reperfusion injury

Ischemia/reperfusion injury (IRI) causes inflammation and cell injury as a result of activating innate immune signaling. Toll-like receptor 4 (TLR4) has a key role in mediating kidney damages during IRI, but the downstream signaling pathway(s) stimulating apoptosis remains debated. In this study we...

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Veröffentlicht in:Cell death and differentiation 2010-09, Vol.17 (9), p.1474-1485
Hauptverfasser: Ben Mkaddem, S, Pedruzzi, E, Werts, C, Coant, N, Bens, M, Cluzeaud, F, Goujon, J M, Ogier-Denis, E, Vandewalle, A
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Sprache:eng
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