Schizophrenia and language — Shall we look for a deficit of deviance detection?
Abstract In this article, we consider the view on schizophrenia that asserts this disease originates from a deficit in the hemispheric specialization for language. We suggest that a deficit in the hemispheric specialization for language may be a consequence of the other recently shown neurophysiolog...
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Veröffentlicht in: | Psychiatry research 2010-07, Vol.178 (2), p.225-229 |
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description | Abstract In this article, we consider the view on schizophrenia that asserts this disease originates from a deficit in the hemispheric specialization for language. We suggest that a deficit in the hemispheric specialization for language may be a consequence of the other recently shown neurophysiological deficit of schizophrenia, namely deviance detection. We hypothesise that a deficit of deviance detection related to the dysfunction of NMDA receptors in schizophrenia leads to the abnormal interaction between the parallel and sequential streams of speech processing in the brain. This hypothesis opens perspectives for genetic, molecular and pharmacological studies of the deficit of deviance detection in schizophrenia, as reflected by event-related potentials and neuroimaging during speech processing. |
doi_str_mv | 10.1016/j.psychres.2010.04.025 |
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Psychiatry</topic><topic>Psychoses</topic><topic>Receptors, N-Methyl-D-Aspartate - metabolism</topic><topic>Schizophrenia</topic><topic>Schizophrenia - complications</topic><topic>Schizophrenia - pathology</topic><topic>Speech - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Strelnikov, Kuzma</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><jtitle>Psychiatry research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Strelnikov, Kuzma</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Schizophrenia and language — Shall we look for a deficit of deviance detection?</atitle><jtitle>Psychiatry research</jtitle><addtitle>Psychiatry Res</addtitle><date>2010-07-30</date><risdate>2010</risdate><volume>178</volume><issue>2</issue><spage>225</spage><epage>229</epage><pages>225-229</pages><issn>0165-1781</issn><eissn>1872-7123</eissn><coden>PSRSDR</coden><abstract>Abstract In this article, we consider the view on schizophrenia that asserts this disease originates from a deficit in the hemispheric specialization for language. 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subjects | Adult and adolescent clinical studies Biological and medical sciences Brain - pathology Brain - physiopathology Dominance, Cerebral - physiology Glutamate Hemispheric specialization Humans Language Language Disorders - etiology Life Sciences Medical sciences Neurons and Cognition NMDA Psychiatry Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Psychoses Receptors, N-Methyl-D-Aspartate - metabolism Schizophrenia Schizophrenia - complications Schizophrenia - pathology Speech - physiology |
title | Schizophrenia and language — Shall we look for a deficit of deviance detection? |
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