Schizophrenia and language — Shall we look for a deficit of deviance detection?

Abstract In this article, we consider the view on schizophrenia that asserts this disease originates from a deficit in the hemispheric specialization for language. We suggest that a deficit in the hemispheric specialization for language may be a consequence of the other recently shown neurophysiolog...

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Veröffentlicht in:Psychiatry research 2010-07, Vol.178 (2), p.225-229
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description Abstract In this article, we consider the view on schizophrenia that asserts this disease originates from a deficit in the hemispheric specialization for language. We suggest that a deficit in the hemispheric specialization for language may be a consequence of the other recently shown neurophysiological deficit of schizophrenia, namely deviance detection. We hypothesise that a deficit of deviance detection related to the dysfunction of NMDA receptors in schizophrenia leads to the abnormal interaction between the parallel and sequential streams of speech processing in the brain. This hypothesis opens perspectives for genetic, molecular and pharmacological studies of the deficit of deviance detection in schizophrenia, as reflected by event-related potentials and neuroimaging during speech processing.
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subjects Adult and adolescent clinical studies
Biological and medical sciences
Brain - pathology
Brain - physiopathology
Dominance, Cerebral - physiology
Glutamate
Hemispheric specialization
Humans
Language
Language Disorders - etiology
Life Sciences
Medical sciences
Neurons and Cognition
NMDA
Psychiatry
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Psychoses
Receptors, N-Methyl-D-Aspartate - metabolism
Schizophrenia
Schizophrenia - complications
Schizophrenia - pathology
Speech - physiology
title Schizophrenia and language — Shall we look for a deficit of deviance detection?
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