Transrectal high-intensity focused ultrasound (HIFU) treatment of localized prostate cancer: review of technical incidents and morbidity after 5 years of use
The objective of this study was to report on technical incidents and early and late complications occurring in high-intensity focused ultrasound (HIFU) treatment of patients with localized prostate cancer. We performed a retrospective review of patients who were treated by Ablatherm at our centre. W...
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| Veröffentlicht in: | Prostate cancer and prostatic diseases 2010-06, Vol.13 (2), p.132-137 |
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| creator | Ripert, T Azémar, M-D Ménard, J Bayoud, Y Messaoudi, R Duval, F Staerman, F |
| description | The objective of this study was to report on technical incidents and early and late complications occurring in high-intensity focused ultrasound (HIFU) treatment of patients with localized prostate cancer. We performed a retrospective review of patients who were treated by Ablatherm at our centre. We recorded all technical incidents, treatment discontinuations and early ( |
| doi_str_mv | 10.1038/pcan.2009.57 |
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de novo
erectile dysfunction rate was 77.1%. Nine complications (16.4%) required surgical management. The overall complication rate was 49%. Ablatherm is a reliable technique with a relatively high complication rate. However, most complications were minor and required surgical management in a few cases only. Our results confirm that all patients who are offered HIFU treatment should be properly informed of the risks, in particular with regard to continence and sexual function.</description><identifier>ISSN: 1365-7852</identifier><identifier>EISSN: 1476-5608</identifier><identifier>DOI: 10.1038/pcan.2009.57</identifier><identifier>PMID: 20048758</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>692/699/67/589/466 ; 692/700/565/2194 ; Ablation ; Aged ; Biomedical and Life Sciences ; Biomedicine ; Cancer Research ; Care and treatment ; Complications ; Complications and side effects ; Erectile dysfunction ; Erectile Dysfunction - etiology ; Hematuria ; Humans ; Male ; Morbidity ; original-article ; Patients ; Prostate - surgery ; Prostate cancer ; Prostatic Neoplasms - surgery ; Radiation therapy ; Retrospective Studies ; Salvage Therapy - adverse effects ; Stenosis ; Transurethral Resection of Prostate ; Ultrasonic imaging ; Ultrasonic waves ; Ultrasound ; Ultrasound, High-Intensity Focused, Transrectal - adverse effects ; Urethral Stricture - etiology ; Urinary incontinence ; Urinary Incontinence - etiology</subject><ispartof>Prostate cancer and prostatic diseases, 2010-06, Vol.13 (2), p.132-137</ispartof><rights>Springer Nature Limited 2010</rights><rights>COPYRIGHT 2010 Nature Publishing Group</rights><rights>Copyright Nature Publishing Group Jun 2010</rights><rights>Nature Publishing Group 2010.</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c516t-5c1ec61d65f3d82aaeb0f05d8da8d1440a1b0ee7cfdd436bcc84400dc712af33</citedby><cites>FETCH-LOGICAL-c516t-5c1ec61d65f3d82aaeb0f05d8da8d1440a1b0ee7cfdd436bcc84400dc712af33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/pcan.2009.57$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/pcan.2009.57$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>230,314,777,781,882,27905,27906,41469,42538,51300</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20048758$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.science/hal-00497402$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Ripert, T</creatorcontrib><creatorcontrib>Azémar, M-D</creatorcontrib><creatorcontrib>Ménard, J</creatorcontrib><creatorcontrib>Bayoud, Y</creatorcontrib><creatorcontrib>Messaoudi, R</creatorcontrib><creatorcontrib>Duval, F</creatorcontrib><creatorcontrib>Staerman, F</creatorcontrib><title>Transrectal high-intensity focused ultrasound (HIFU) treatment of localized prostate cancer: review of technical incidents and morbidity after 5 years of use</title><title>Prostate cancer and prostatic diseases</title><addtitle>Prostate Cancer Prostatic Dis</addtitle><addtitle>Prostate Cancer Prostatic Dis</addtitle><description>The objective of this study was to report on technical incidents and early and late complications occurring in high-intensity focused ultrasound (HIFU) treatment of patients with localized prostate cancer. We performed a retrospective review of patients who were treated by Ablatherm at our centre. We recorded all technical incidents, treatment discontinuations and early (<1 month) and late complications. A total of 74 HIFU procedures were performed in 65 patients (55 first-line HIFU treatments and 10 cases of salvage therapy after radiotherapy) over a 5-year period. Median follow-up was 41 months (10–64 months). All the procedures were well tolerated and no intra- or peri-operative deaths occurred. Six technical incidents in the overall population (8.1%) led to discontinuation of the procedure. The early complication rate in patients undergoing first-line HIFU was 36.4%: urinary retention (20%), dysuria (5.4%), urinary infection (3.6%), haematuria (3.6%) and urethral stenosis (3.6%). The late complication rate was 12.7%: urethral stenosis (9%) and dysuria (3.6%). There were no cases of rectourethral fistula. The long-term urinary incontinence rate was 20% and the
de novo
erectile dysfunction rate was 77.1%. Nine complications (16.4%) required surgical management. The overall complication rate was 49%. Ablatherm is a reliable technique with a relatively high complication rate. However, most complications were minor and required surgical management in a few cases only. Our results confirm that all patients who are offered HIFU treatment should be properly informed of the risks, in particular with regard to continence and sexual function.</description><subject>692/699/67/589/466</subject><subject>692/700/565/2194</subject><subject>Ablation</subject><subject>Aged</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cancer Research</subject><subject>Care and treatment</subject><subject>Complications</subject><subject>Complications and side effects</subject><subject>Erectile dysfunction</subject><subject>Erectile Dysfunction - etiology</subject><subject>Hematuria</subject><subject>Humans</subject><subject>Male</subject><subject>Morbidity</subject><subject>original-article</subject><subject>Patients</subject><subject>Prostate - surgery</subject><subject>Prostate cancer</subject><subject>Prostatic Neoplasms - surgery</subject><subject>Radiation therapy</subject><subject>Retrospective Studies</subject><subject>Salvage Therapy - adverse effects</subject><subject>Stenosis</subject><subject>Transurethral Resection of Prostate</subject><subject>Ultrasonic imaging</subject><subject>Ultrasonic waves</subject><subject>Ultrasound</subject><subject>Ultrasound, High-Intensity Focused, Transrectal - adverse effects</subject><subject>Urethral Stricture - etiology</subject><subject>Urinary incontinence</subject><subject>Urinary Incontinence - etiology</subject><issn>1365-7852</issn><issn>1476-5608</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqFksFu1DAQhiMEoqVw44wsOEAlsthOHCfcVhVlK63EZTlbjj3ZdZU4i-0ULe_CuzLRllagIuSDrfE3_8zYf5a9ZHTBaFF_2BvtF5zSZiHko-yUlbLKRUXrx3guKpHLWvCT7FmM1xQh1tCn2QniZS1FfZr93ATtYwCTdE92brvLnU_go0sH0o1mimDJ1Keg4zh5S96tri6_npMUQKcBfCJjR_rR6N79QHAfxph0AoItGQgfSYAbB99nKIHZeYcgcd44i6mRaBQcxtA6O1fTXYJABDmADnFOwdrPsyed7iO8uN3Pss3lp83FKl9_-Xx1sVznRrAq5cIwMBWzlegKW3OtoaUdFba2urasLKlmLQWQprO2LKrWmBqD1BrJuO6K4iw7P8rudK_2wQ06HNSonVot12qO4XM1sqT8hiH79sjisN8miEkNLhroe-1hnKKSpagKwUXxf7IoBEN41nzzF3k9TsHjxIpXpSh4SeVMvf4nxRtKK14191Jb3YNyvhvx78xcWC05l1w2VJZILR6gcFkYnBk9dA7jfyS8PyYY_GK0S3f3TIyq2YZqtqGabaiERPzVbatTO4C9g3_7DoH8CES88lsI97M8KPgLd5znCw</recordid><startdate>20100601</startdate><enddate>20100601</enddate><creator>Ripert, T</creator><creator>Azémar, M-D</creator><creator>Ménard, J</creator><creator>Bayoud, Y</creator><creator>Messaoudi, R</creator><creator>Duval, F</creator><creator>Staerman, F</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TO</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>M7Z</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>7QO</scope><scope>1XC</scope><scope>VOOES</scope></search><sort><creationdate>20100601</creationdate><title>Transrectal high-intensity focused ultrasound (HIFU) treatment of localized prostate cancer: review of technical incidents and morbidity after 5 years of use</title><author>Ripert, T ; Azémar, M-D ; Ménard, J ; Bayoud, Y ; Messaoudi, R ; Duval, F ; Staerman, F</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c516t-5c1ec61d65f3d82aaeb0f05d8da8d1440a1b0ee7cfdd436bcc84400dc712af33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>692/699/67/589/466</topic><topic>692/700/565/2194</topic><topic>Ablation</topic><topic>Aged</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Cancer Research</topic><topic>Care and treatment</topic><topic>Complications</topic><topic>Complications and side effects</topic><topic>Erectile dysfunction</topic><topic>Erectile Dysfunction - 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Academic</collection><collection>Biotechnology Research Abstracts</collection><collection>Hyper Article en Ligne (HAL)</collection><collection>Hyper Article en Ligne (HAL) (Open Access)</collection><jtitle>Prostate cancer and prostatic diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ripert, T</au><au>Azémar, M-D</au><au>Ménard, J</au><au>Bayoud, Y</au><au>Messaoudi, R</au><au>Duval, F</au><au>Staerman, F</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Transrectal high-intensity focused ultrasound (HIFU) treatment of localized prostate cancer: review of technical incidents and morbidity after 5 years of use</atitle><jtitle>Prostate cancer and prostatic diseases</jtitle><stitle>Prostate Cancer Prostatic Dis</stitle><addtitle>Prostate Cancer Prostatic Dis</addtitle><date>2010-06-01</date><risdate>2010</risdate><volume>13</volume><issue>2</issue><spage>132</spage><epage>137</epage><pages>132-137</pages><issn>1365-7852</issn><eissn>1476-5608</eissn><abstract>The objective of this study was to report on technical incidents and early and late complications occurring in high-intensity focused ultrasound (HIFU) treatment of patients with localized prostate cancer. We performed a retrospective review of patients who were treated by Ablatherm at our centre. We recorded all technical incidents, treatment discontinuations and early (<1 month) and late complications. A total of 74 HIFU procedures were performed in 65 patients (55 first-line HIFU treatments and 10 cases of salvage therapy after radiotherapy) over a 5-year period. Median follow-up was 41 months (10–64 months). All the procedures were well tolerated and no intra- or peri-operative deaths occurred. Six technical incidents in the overall population (8.1%) led to discontinuation of the procedure. The early complication rate in patients undergoing first-line HIFU was 36.4%: urinary retention (20%), dysuria (5.4%), urinary infection (3.6%), haematuria (3.6%) and urethral stenosis (3.6%). The late complication rate was 12.7%: urethral stenosis (9%) and dysuria (3.6%). There were no cases of rectourethral fistula. The long-term urinary incontinence rate was 20% and the
de novo
erectile dysfunction rate was 77.1%. Nine complications (16.4%) required surgical management. The overall complication rate was 49%. Ablatherm is a reliable technique with a relatively high complication rate. However, most complications were minor and required surgical management in a few cases only. Our results confirm that all patients who are offered HIFU treatment should be properly informed of the risks, in particular with regard to continence and sexual function.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>20048758</pmid><doi>10.1038/pcan.2009.57</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Prostate cancer and prostatic diseases, 2010-06, Vol.13 (2), p.132-137 |
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| source | MEDLINE; Springer journals; EZB Electronic Journals Library |
| subjects | 692/699/67/589/466 692/700/565/2194 Ablation Aged Biomedical and Life Sciences Biomedicine Cancer Research Care and treatment Complications Complications and side effects Erectile dysfunction Erectile Dysfunction - etiology Hematuria Humans Male Morbidity original-article Patients Prostate - surgery Prostate cancer Prostatic Neoplasms - surgery Radiation therapy Retrospective Studies Salvage Therapy - adverse effects Stenosis Transurethral Resection of Prostate Ultrasonic imaging Ultrasonic waves Ultrasound Ultrasound, High-Intensity Focused, Transrectal - adverse effects Urethral Stricture - etiology Urinary incontinence Urinary Incontinence - etiology |
| title | Transrectal high-intensity focused ultrasound (HIFU) treatment of localized prostate cancer: review of technical incidents and morbidity after 5 years of use |
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