Human papillomavirus (HPV) genotype distribution in invasive cervical cancers in France: EDITH study
Invasive cervical cancer (ICC) remains a significant cause of morbidity and mortality in France. Since human papillomavirus (HPV) is the necessary cause of ICC, the aim of this study was to assess the type‐specific prevalence of HPV in ICC in France in order to locally evaluate the potential benefit...
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| Veröffentlicht in: | International journal of cancer 2008-01, Vol.122 (2), p.428-432 |
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| creator | Prétet, Jean‐Luc Jacquard, Anne‐Carole Carcopino, Xavier Charlot, Jean‐François Bouhour, Damien Kantelip, Bernadette Soubeyrand, Benoit Leocmach, Yann Mougin, Christiane Riethmuller, Didier |
| description | Invasive cervical cancer (ICC) remains a significant cause of morbidity and mortality in France. Since human papillomavirus (HPV) is the necessary cause of ICC, the aim of this study was to assess the type‐specific prevalence of HPV in ICC in France in order to locally evaluate the potential benefit of an HPV 16/18 L1 virus‐like particles (VLP) vaccination. A total of 516 histological specimens collected in 15 centers were analyzed. Among them, 86% had a diagnosis of squamous cell carcinoma (SCC) whereas 14% were adenocarcinomas (ADC). HPV genotyping was performed using the INNO‐LiPA assay allowing the specific detection of 24 HPV genotypes both high risk (HR) and low risk (LR). The overall HPV prevalence in ICC was 97%. The most prevalent genotypes were HPV 16 (73%) and HPV 18 (19%) followed by HPV 31 (7%), 33, 68, 45, 52 and 58 (4.1–2.3%). HPV 16 and/or 18 were associated with 82% of ICC, 10% being HPV 16 and 18 coinfections. While HPV 16 was the most prevalent type in both SCC (74%) and ADC (64%), HPV 18 was by far more prevalent in ADC (37%) compared to SCC (16%; p < 0.001). Multiple infections with at least two different HR HPV genotypes were observed in 22% of ICC. Given the high HPV 16/18 prevalence and taking into account possible production of crossneutralizing antibodies against other HPV types, HPV 16/18 L1 VLP vaccination would be expected to significantly reduce the burden of ICC in France. © 2007 Wiley‐Liss, Inc. |
| doi_str_mv | 10.1002/ijc.23092 |
| format | Article |
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Since human papillomavirus (HPV) is the necessary cause of ICC, the aim of this study was to assess the type‐specific prevalence of HPV in ICC in France in order to locally evaluate the potential benefit of an HPV 16/18 L1 virus‐like particles (VLP) vaccination. A total of 516 histological specimens collected in 15 centers were analyzed. Among them, 86% had a diagnosis of squamous cell carcinoma (SCC) whereas 14% were adenocarcinomas (ADC). HPV genotyping was performed using the INNO‐LiPA assay allowing the specific detection of 24 HPV genotypes both high risk (HR) and low risk (LR). The overall HPV prevalence in ICC was 97%. The most prevalent genotypes were HPV 16 (73%) and HPV 18 (19%) followed by HPV 31 (7%), 33, 68, 45, 52 and 58 (4.1–2.3%). HPV 16 and/or 18 were associated with 82% of ICC, 10% being HPV 16 and 18 coinfections. While HPV 16 was the most prevalent type in both SCC (74%) and ADC (64%), HPV 18 was by far more prevalent in ADC (37%) compared to SCC (16%; p < 0.001). Multiple infections with at least two different HR HPV genotypes were observed in 22% of ICC. Given the high HPV 16/18 prevalence and taking into account possible production of crossneutralizing antibodies against other HPV types, HPV 16/18 L1 VLP vaccination would be expected to significantly reduce the burden of ICC in France. © 2007 Wiley‐Liss, Inc.</description><identifier>ISSN: 0020-7136</identifier><identifier>EISSN: 1097-0215</identifier><identifier>DOI: 10.1002/ijc.23092</identifier><identifier>PMID: 17893882</identifier><identifier>CODEN: IJCNAW</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Adult ; Aged ; Biological and medical sciences ; Cancer ; Cancer Vaccines ; Cervical Intraepithelial Neoplasia ; Cervical Intraepithelial Neoplasia - genetics ; Cervical Intraepithelial Neoplasia - virology ; Female ; Female genital diseases ; France ; Genotype ; Gynecology. Andrology. Obstetrics ; Human papillomavirus ; Humans ; invasive cervical cancer ; Life Sciences ; Medical sciences ; Middle Aged ; Papillomaviridae ; Papillomaviridae - genetics ; Precancerous Conditions ; Precancerous Conditions - genetics ; Precancerous Conditions - virology ; Prevalence ; Risk ; Tumors ; Uterine Cervical Neoplasms ; Uterine Cervical Neoplasms - genetics ; Uterine Cervical Neoplasms - virology</subject><ispartof>International journal of cancer, 2008-01, Vol.122 (2), p.428-432</ispartof><rights>Copyright © 2007 Wiley‐Liss, Inc.</rights><rights>2008 INIST-CNRS</rights><rights>Copyright 2007 Wiley-Liss, Inc.</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4182-d40d26e3ed010ab56faf2860e56667acb49e4513d5ee44073199b014905f204e3</citedby><cites>FETCH-LOGICAL-c4182-d40d26e3ed010ab56faf2860e56667acb49e4513d5ee44073199b014905f204e3</cites><orcidid>0000-0002-8430-214X ; 0000-0002-9533-3558</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fijc.23092$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fijc.23092$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,314,776,780,881,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19901068$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17893882$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.science/hal-00484957$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Prétet, Jean‐Luc</creatorcontrib><creatorcontrib>Jacquard, Anne‐Carole</creatorcontrib><creatorcontrib>Carcopino, Xavier</creatorcontrib><creatorcontrib>Charlot, Jean‐François</creatorcontrib><creatorcontrib>Bouhour, Damien</creatorcontrib><creatorcontrib>Kantelip, Bernadette</creatorcontrib><creatorcontrib>Soubeyrand, Benoit</creatorcontrib><creatorcontrib>Leocmach, Yann</creatorcontrib><creatorcontrib>Mougin, Christiane</creatorcontrib><creatorcontrib>Riethmuller, Didier</creatorcontrib><creatorcontrib>EDITH study group</creatorcontrib><creatorcontrib>for the EDITH study group</creatorcontrib><title>Human papillomavirus (HPV) genotype distribution in invasive cervical cancers in France: EDITH study</title><title>International journal of cancer</title><addtitle>Int J Cancer</addtitle><description>Invasive cervical cancer (ICC) remains a significant cause of morbidity and mortality in France. Since human papillomavirus (HPV) is the necessary cause of ICC, the aim of this study was to assess the type‐specific prevalence of HPV in ICC in France in order to locally evaluate the potential benefit of an HPV 16/18 L1 virus‐like particles (VLP) vaccination. A total of 516 histological specimens collected in 15 centers were analyzed. Among them, 86% had a diagnosis of squamous cell carcinoma (SCC) whereas 14% were adenocarcinomas (ADC). HPV genotyping was performed using the INNO‐LiPA assay allowing the specific detection of 24 HPV genotypes both high risk (HR) and low risk (LR). The overall HPV prevalence in ICC was 97%. The most prevalent genotypes were HPV 16 (73%) and HPV 18 (19%) followed by HPV 31 (7%), 33, 68, 45, 52 and 58 (4.1–2.3%). HPV 16 and/or 18 were associated with 82% of ICC, 10% being HPV 16 and 18 coinfections. While HPV 16 was the most prevalent type in both SCC (74%) and ADC (64%), HPV 18 was by far more prevalent in ADC (37%) compared to SCC (16%; p < 0.001). Multiple infections with at least two different HR HPV genotypes were observed in 22% of ICC. Given the high HPV 16/18 prevalence and taking into account possible production of crossneutralizing antibodies against other HPV types, HPV 16/18 L1 VLP vaccination would be expected to significantly reduce the burden of ICC in France. © 2007 Wiley‐Liss, Inc.</description><subject>Adult</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Cancer</subject><subject>Cancer Vaccines</subject><subject>Cervical Intraepithelial Neoplasia</subject><subject>Cervical Intraepithelial Neoplasia - genetics</subject><subject>Cervical Intraepithelial Neoplasia - virology</subject><subject>Female</subject><subject>Female genital diseases</subject><subject>France</subject><subject>Genotype</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Human papillomavirus</subject><subject>Humans</subject><subject>invasive cervical cancer</subject><subject>Life Sciences</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Papillomaviridae</subject><subject>Papillomaviridae - genetics</subject><subject>Precancerous Conditions</subject><subject>Precancerous Conditions - genetics</subject><subject>Precancerous Conditions - virology</subject><subject>Prevalence</subject><subject>Risk</subject><subject>Tumors</subject><subject>Uterine Cervical Neoplasms</subject><subject>Uterine Cervical Neoplasms - genetics</subject><subject>Uterine Cervical Neoplasms - virology</subject><issn>0020-7136</issn><issn>1097-0215</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1v1DAQhi0EotvCgT-AfAG1h7Rjx_EHt2ppyVYrlUPbq-UkDrjKV-0kaP89DrtiTwhppBl5Hs1rvS9CHwhcEgB65Z7LS5qCoq_QioASCVCSvUaruINEkJSfoNMQngEIyYC9RSdESJVKSVeoyqfWdHgwg2uavjWz81PA5_n3pwv8w3b9uBssrlwYvSum0fUddkvNJrjZ4tL62ZWmwaXp4hyW5a1f5i_45uvmIcdhnKrdO_SmNk2w7w_9DD3e3jys82R7_22zvt4mJSOSJhWDinKb2goImCLjtamp5GAzzrkwZcGUZRlJq8xaxkCkRKkCCFOQ1RSYTc_Qxf7uT9PowbvW-J3ujdP59VYvbwBMMpWJmUT2854dfP8y2TDq1oXSNo3pbD8FLQAkUJn-F6TAheRMHNVL34fgbf33CwT0kpOOOek_OUX24-HoVLS2OpKHYCLw6QCYEA2uF1NdOHJKRY-4jNzVnvvlGrv7t6Le3K330r8BZPynCg</recordid><startdate>20080115</startdate><enddate>20080115</enddate><creator>Prétet, Jean‐Luc</creator><creator>Jacquard, Anne‐Carole</creator><creator>Carcopino, Xavier</creator><creator>Charlot, Jean‐François</creator><creator>Bouhour, Damien</creator><creator>Kantelip, Bernadette</creator><creator>Soubeyrand, Benoit</creator><creator>Leocmach, Yann</creator><creator>Mougin, Christiane</creator><creator>Riethmuller, Didier</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley-Liss</general><general>Wiley</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TO</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope><scope>1XC</scope><orcidid>https://orcid.org/0000-0002-8430-214X</orcidid><orcidid>https://orcid.org/0000-0002-9533-3558</orcidid></search><sort><creationdate>20080115</creationdate><title>Human papillomavirus (HPV) genotype distribution in invasive cervical cancers in France: EDITH study</title><author>Prétet, Jean‐Luc ; Jacquard, Anne‐Carole ; Carcopino, Xavier ; Charlot, Jean‐François ; Bouhour, Damien ; Kantelip, Bernadette ; Soubeyrand, Benoit ; Leocmach, Yann ; Mougin, Christiane ; Riethmuller, Didier</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4182-d40d26e3ed010ab56faf2860e56667acb49e4513d5ee44073199b014905f204e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Cancer</topic><topic>Cancer Vaccines</topic><topic>Cervical Intraepithelial Neoplasia</topic><topic>Cervical Intraepithelial Neoplasia - genetics</topic><topic>Cervical Intraepithelial Neoplasia - virology</topic><topic>Female</topic><topic>Female genital diseases</topic><topic>France</topic><topic>Genotype</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Human papillomavirus</topic><topic>Humans</topic><topic>invasive cervical cancer</topic><topic>Life Sciences</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Papillomaviridae</topic><topic>Papillomaviridae - genetics</topic><topic>Precancerous Conditions</topic><topic>Precancerous Conditions - genetics</topic><topic>Precancerous Conditions - virology</topic><topic>Prevalence</topic><topic>Risk</topic><topic>Tumors</topic><topic>Uterine Cervical Neoplasms</topic><topic>Uterine Cervical Neoplasms - genetics</topic><topic>Uterine Cervical Neoplasms - virology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Prétet, Jean‐Luc</creatorcontrib><creatorcontrib>Jacquard, Anne‐Carole</creatorcontrib><creatorcontrib>Carcopino, Xavier</creatorcontrib><creatorcontrib>Charlot, Jean‐François</creatorcontrib><creatorcontrib>Bouhour, Damien</creatorcontrib><creatorcontrib>Kantelip, Bernadette</creatorcontrib><creatorcontrib>Soubeyrand, Benoit</creatorcontrib><creatorcontrib>Leocmach, Yann</creatorcontrib><creatorcontrib>Mougin, Christiane</creatorcontrib><creatorcontrib>Riethmuller, Didier</creatorcontrib><creatorcontrib>EDITH study group</creatorcontrib><creatorcontrib>for the EDITH study group</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><jtitle>International journal of cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Prétet, Jean‐Luc</au><au>Jacquard, Anne‐Carole</au><au>Carcopino, Xavier</au><au>Charlot, Jean‐François</au><au>Bouhour, Damien</au><au>Kantelip, Bernadette</au><au>Soubeyrand, Benoit</au><au>Leocmach, Yann</au><au>Mougin, Christiane</au><au>Riethmuller, Didier</au><aucorp>EDITH study group</aucorp><aucorp>for the EDITH study group</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Human papillomavirus (HPV) genotype distribution in invasive cervical cancers in France: EDITH study</atitle><jtitle>International journal of cancer</jtitle><addtitle>Int J Cancer</addtitle><date>2008-01-15</date><risdate>2008</risdate><volume>122</volume><issue>2</issue><spage>428</spage><epage>432</epage><pages>428-432</pages><issn>0020-7136</issn><eissn>1097-0215</eissn><coden>IJCNAW</coden><abstract>Invasive cervical cancer (ICC) remains a significant cause of morbidity and mortality in France. Since human papillomavirus (HPV) is the necessary cause of ICC, the aim of this study was to assess the type‐specific prevalence of HPV in ICC in France in order to locally evaluate the potential benefit of an HPV 16/18 L1 virus‐like particles (VLP) vaccination. A total of 516 histological specimens collected in 15 centers were analyzed. Among them, 86% had a diagnosis of squamous cell carcinoma (SCC) whereas 14% were adenocarcinomas (ADC). HPV genotyping was performed using the INNO‐LiPA assay allowing the specific detection of 24 HPV genotypes both high risk (HR) and low risk (LR). The overall HPV prevalence in ICC was 97%. The most prevalent genotypes were HPV 16 (73%) and HPV 18 (19%) followed by HPV 31 (7%), 33, 68, 45, 52 and 58 (4.1–2.3%). HPV 16 and/or 18 were associated with 82% of ICC, 10% being HPV 16 and 18 coinfections. While HPV 16 was the most prevalent type in both SCC (74%) and ADC (64%), HPV 18 was by far more prevalent in ADC (37%) compared to SCC (16%; p < 0.001). Multiple infections with at least two different HR HPV genotypes were observed in 22% of ICC. Given the high HPV 16/18 prevalence and taking into account possible production of crossneutralizing antibodies against other HPV types, HPV 16/18 L1 VLP vaccination would be expected to significantly reduce the burden of ICC in France. © 2007 Wiley‐Liss, Inc.</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>17893882</pmid><doi>10.1002/ijc.23092</doi><tpages>5</tpages><orcidid>https://orcid.org/0000-0002-8430-214X</orcidid><orcidid>https://orcid.org/0000-0002-9533-3558</orcidid></addata></record> |
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| subjects | Adult Aged Biological and medical sciences Cancer Cancer Vaccines Cervical Intraepithelial Neoplasia Cervical Intraepithelial Neoplasia - genetics Cervical Intraepithelial Neoplasia - virology Female Female genital diseases France Genotype Gynecology. Andrology. Obstetrics Human papillomavirus Humans invasive cervical cancer Life Sciences Medical sciences Middle Aged Papillomaviridae Papillomaviridae - genetics Precancerous Conditions Precancerous Conditions - genetics Precancerous Conditions - virology Prevalence Risk Tumors Uterine Cervical Neoplasms Uterine Cervical Neoplasms - genetics Uterine Cervical Neoplasms - virology |
| title | Human papillomavirus (HPV) genotype distribution in invasive cervical cancers in France: EDITH study |
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