Gain of oncogenic function of p53 mutants regulates E-cadherin expression uncoupled from cell invasion in colon cancer cells

Mutations in the p53 tumour suppressor gene are associated clinically with tumour progression and metastasis. Downregulation of the E-cadherin cell-cell adhesion molecule is a key event for epithelial to mesenchymal transition (EMT) in tumour progression. Here, we show that wild-type p53 induced to...

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Veröffentlicht in:	Journal of cell science 2010-04, Vol.123 (8), p.1295-1305
Hauptverfasser:	Roger, Lauréline, Jullien, Laurent, Gire, Véronique, Roux, Pierre
Format:	Artikel
Sprache:	eng
Schlagworte:	Biochemistry, Molecular Biology Cadherins - genetics Cadherins - metabolism Cell Line, Tumor Collagen - metabolism Colonic Neoplasms - genetics Colonic Neoplasms - pathology Cyclin-Dependent Kinase Inhibitor p21 - deficiency Down-Regulation - genetics Drug Combinations Epithelium - pathology Gene Expression Regulation, Neoplastic Humans Laminin - metabolism Life Sciences Mesoderm - pathology Mutant Proteins - metabolism Mutation - genetics Neoplasm Invasiveness Phenotype Proteoglycans - metabolism Reproducibility of Results RNA, Messenger - genetics RNA, Messenger - metabolism Transcription, Genetic Transcriptional Activation - genetics Tumor Suppressor Protein p53 - genetics Tumor Suppressor Protein p53 - metabolism Vimentin - genetics Vimentin - metabolism
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