Comparison of the cellular and biochemical properties of Plasmodium falciparum choline and ethanolamine kinases

The proliferation of the malaria-causing parasite Plasmodium falciparum within the erythrocyte is concomitant with massive phosphatidylcholine and phosphatidylethanolamine biosynthesis. Based on pharmacological and genetic data, de novo biosynthesis pathways of both phospholipids appear to be essent...

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Veröffentlicht in:	Biochemical journal 2010-01, Vol.425 (1), p.149-163
Hauptverfasser:	Alberge, Blandine, Gannoun-Zaki, Leila, Bascunana, Céline, Tran van Ba, Christophe, Vial, Henri, Cerdan, Rachel
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Alcohols - pharmacology Antimalarials - pharmacology Binding Sites - genetics Blotting, Western Catalysis - drug effects Choline - metabolism Choline Kinase - chemistry Choline Kinase - genetics Choline Kinase - metabolism Circular Dichroism Crystallography, X-Ray Escherichia coli - genetics Ethanolamines - metabolism Hemicholinium 3 - pharmacology Kinetics Life Sciences Microbiology and Parasitology Microscopy, Fluorescence Phosphotransferases (Alcohol Group Acceptor) - chemistry Phosphotransferases (Alcohol Group Acceptor) - genetics Phosphotransferases (Alcohol Group Acceptor) - metabolism Plasmodium falciparum - enzymology Plasmodium falciparum - genetics Protein Structure, Secondary Protein Structure, Tertiary Protozoan Proteins - chemistry Protozoan Proteins - genetics Protozoan Proteins - metabolism Recombinant Proteins - chemistry Recombinant Proteins - metabolism Substrate Specificity Thiazoles - pharmacology
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