Detection of occult HER2 mRNA-positive tumor cells in the peripheral blood of patients with operable breast cancer: evaluation of their prognostic relevance

To evaluate whether HER2 mRNA could be used as a marker of circulating tumor cells (CTCs) in women with operable breast cancer. A nested RT-PCR assay was developed and used for the detection of HER2 mRNA-positive CTCs. Blood from 216 women with early breast cancer obtained before adjuvant treatment...

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Veröffentlicht in:	Breast cancer research and treatment 2009-10, Vol.117 (3), p.525-534
Hauptverfasser:	Apostolaki, Stella, Perraki, Maria, Kallergi, Galatea, Kafousi, Maria, Papadopoulos, Savvas, Kotsakis, Athanasios, Pallis, Athanasios, Xenidis, Nikolaos, Kalmanti, Lyda, Kalbakis, Kostas, Agelaki, Sofia, Kalykaki, Antonia, Stournaras, Christos, Stathopoulos, Efstathios, Georgoulias, Vassilis, Mavroudis, Dimitris
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Biological and medical sciences Biomarkers Biomarkers, Tumor - blood Biomarkers, Tumor - genetics Breast cancer Breast Neoplasms - blood Breast Neoplasms - genetics Breast Neoplasms - pathology Cancer research Cancer therapies Cells Disease-Free Survival Female Fluorescent Antibody Technique Gynecology. Andrology. Obstetrics Humans In Situ Hybridization, Fluorescence Kaplan-Meier Estimate Mammary gland diseases Medical prognosis Medical sciences Medicine Medicine & Public Health Microscopy, Confocal Middle Aged Neoplasm Staging Neoplastic Cells, Circulating - metabolism Neoplastic Cells, Circulating - pathology Oncology Preclinical Study Prognosis Receptor, ErbB-2 - genetics Receptor, ErbB-2 - metabolism Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - analysis RNA, Messenger - blood Sensitivity and Specificity Tumors
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