No clinically relevant CYP3A induction after St. John's wort with low hyperforin content in healthy volunteers

Objective Induction of CYP3A by St. John's wort (SJW) products with high hyperforin content is well described. Since CYP3A induction is mediated by hyperforin in a concentration-dependent manner, and SJW preparations differ significantly in hyperforin content, the aim of the study was to evalua...

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Veröffentlicht in:	European journal of clinical pharmacology 2009-01, Vol.65 (1), p.81-87
Hauptverfasser:	Mueller, Silke C, Majcher-Peszynska, Jolanta, Mundkowski, Ralf G, Uehleke, Bernhard, Klammt, Sebastian, Sievers, Hartwig, Lehnfeld, Romanus, Frank, Bruno, Thurow, Kerstin, Kundt, Guenther, Drewelow, Bernd
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Adult Biological and medical sciences Biomedical and Life Sciences Biomedicine Bridged Bicyclo Compounds - administration & dosage Bridged Bicyclo Compounds - analysis Bridged Bicyclo Compounds - pharmacology Cross-Over Studies CYP3A Cytochrome P-450 CYP3A - biosynthesis Drug interaction Enzyme Induction Enzymes Herb-Drug Interactions Herbal medicine Humans hyperforin Hypericum Male Medical sciences Midazolam - administration & dosage Midazolam - pharmacokinetics Pharmacokinetics and Disposition Pharmacology Pharmacology. Drug treatments Pharmacology/Toxicology Phloroglucinol - administration & dosage Phloroglucinol - analogs & derivatives Phloroglucinol - analysis Phloroglucinol - pharmacology Plant Preparations - administration & dosage Plant Preparations - chemistry Plant Preparations - pharmacology Powders Substrate Specificity Terpenes - administration & dosage Terpenes - analysis Terpenes - pharmacology Young Adult
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