Passerini Three-Component Reaction of Alcohols under Catalytic Aerobic Oxidative Conditions

Passerini Three-Component Reaction of Alcohols under Catalytic Aerobic Oxidative Conditions

Alcohols instead of aldehydes were used in the Passerini three-component reaction under catalytic aerobic conditions. Mixing alcohols, isocyanides, and carboxylic acids in toluene in the presence of a catalytic amount of cupric chloride, NaNO2, and TEMPO afforded, under an oxygen atmosphere, the P-3...

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Veröffentlicht in:Organic letters 2010-04, Vol.12 (7), p.1432-1435
Hauptverfasser: Brioche, Julien, Masson, Géraldine, Zhu, Jieping
Format: Artikel
Sprache:eng
Schlagworte:
Alcohols - chemistry
Aldehydes - chemical synthesis
Aldehydes - chemistry
Carboxylic Acids - chemistry
Catalysis
Chemical Sciences
Cyanides - chemistry
Molecular Structure
Organic chemistry
Oxidation-Reduction
Oxygen - chemistry
Stereoisomerism
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Zusammenfassung:Alcohols instead of aldehydes were used in the Passerini three-component reaction under catalytic aerobic conditions. Mixing alcohols, isocyanides, and carboxylic acids in toluene in the presence of a catalytic amount of cupric chloride, NaNO2, and TEMPO afforded, under an oxygen atmosphere, the P-3CR adducts in good yields.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol100012y