Stimulation of cyclooxygenase-2-activity by nitric oxide-derived species in rat chondrocyte: lack of contribution to loss of cartilage anabolism1

Cross-talk between inducible nitric oxide synthase (NOS II) and cyclooxygenase-2 (COX-2) was investigated in rat chondrocytes. In monolayers, interleukin-1beta (IL-1beta) induced COX-2 and NOS II expression in a dose- and time-dependent manner, to produce high prostaglandin E(2) (PGE(2)) and nitrite...

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Veröffentlicht in:	Biochemical pharmacology 2001-04, Vol.61 (8), p.965-978
Hauptverfasser:	Nédélec, Emmanuelle, Abid, Amr, Cipolletta, Christine, Presle, Nathalie, Terlain, Bernard, Netter, Patrick, Jouzeau, Jean-Yves
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cartilage Chondrocytes Cyclooxygenase 2 Cyclooxygenase 2 Inhibitors Cyclooxygenase Inhibitors Dose-Response Relationship, Drug Enzyme Activation Enzyme Inhibitors Food and Nutrition Gene Expression Regulation, Enzymologic Indomethacin Interleukin-1 Isoenzymes Life Sciences Male Nitric Oxide Synthase Nitric Oxide Synthase Type II Nitrites Nitrobenzenes omega-N-Methylarginine Prostaglandin-Endoperoxide Synthases Proteoglycans Rats Rats, Wistar Sulfonamides Thiourea
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