Molecular Epidemiology of Norovirus Gastroenteritis Investigated Using Samples Collected from Children in Tunisia during a Four-Year Period: Detection of the Norovirus Variant GGII.4 Hunter as Early as January 2003
Human noroviruses (NoVs) cause epidemic and endemic acute gastroenteritis in children and adults. To study the prevalence and genetic diversity of NoV in children in Tunisia, a total of 788 fecal samples were collected during a 4-year period in the region of Monastir, from children 12 years of age o...
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| Veröffentlicht in: | Journal of Clinical Microbiology 2009-02, Vol.47 (2), p.421-429 |
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| creator | Sdiri-Loulizi, Khira Ambert-Balay, Katia Gharbi-Khelifi, Hakima Sakly, Nabil Hassine, Mouna Chouchane, Slaheddine Guediche, Mohamed Neji Pothier, Pierre Aouni, Mahjoub |
| description | Human noroviruses (NoVs) cause epidemic and endemic acute gastroenteritis in children and adults. To study the prevalence and genetic diversity of NoV in children in Tunisia, a total of 788 fecal samples were collected during a 4-year period in the region of Monastir, from children 12 years of age or younger, hospitalized or presenting in dispensaries with symptoms of acute gastroenteritis. NoV was detected by reverse transcription-PCR and confirmed by sequence analysis. This is the first report that describes the molecular epidemiology of NoV in Tunisian children: NoVs were characterized as the causative agent in 128 (16.2%) of the samples. Fourteen samples contained a mixture of two NoVs, and 33 samples were coinfected with additional enteric viruses. Eight distinct NoV genotypes were detected (GGI.2, GGI.4, GGII.1, GGII.4, GGII.8, GGII.14, GGIIb/GGII.2, and GGIIb/GGII.3). GGII.4 was the most prevalent genotype, accounting for 83 (64.8%) cases. Interestingly the GGII.4 variant Hunter, described as spreading all over the world in 2004, was found in Tunisia as early as January 2003. The delay of 1 year between the isolation in Tunisia and the worldwide emergence is somewhat surprising, considering the importance of the contacts between North Africa and Europe particularly. Nevertheless, this illustrates the idea that sporadic gastroenteritis cases may be a reservoir for emerging epidemic NoV strains. |
| doi_str_mv | 10.1128/jcm.01852-08 |
| format | Article |
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To study the prevalence and genetic diversity of NoV in children in Tunisia, a total of 788 fecal samples were collected during a 4-year period in the region of Monastir, from children 12 years of age or younger, hospitalized or presenting in dispensaries with symptoms of acute gastroenteritis. NoV was detected by reverse transcription-PCR and confirmed by sequence analysis. This is the first report that describes the molecular epidemiology of NoV in Tunisian children: NoVs were characterized as the causative agent in 128 (16.2%) of the samples. Fourteen samples contained a mixture of two NoVs, and 33 samples were coinfected with additional enteric viruses. Eight distinct NoV genotypes were detected (GGI.2, GGI.4, GGII.1, GGII.4, GGII.8, GGII.14, GGIIb/GGII.2, and GGIIb/GGII.3). GGII.4 was the most prevalent genotype, accounting for 83 (64.8%) cases. Interestingly the GGII.4 variant Hunter, described as spreading all over the world in 2004, was found in Tunisia as early as January 2003. The delay of 1 year between the isolation in Tunisia and the worldwide emergence is somewhat surprising, considering the importance of the contacts between North Africa and Europe particularly. Nevertheless, this illustrates the idea that sporadic gastroenteritis cases may be a reservoir for emerging epidemic NoV strains.</description><identifier>ISSN: 0095-1137</identifier><identifier>EISSN: 1098-660X</identifier><identifier>DOI: 10.1128/jcm.01852-08</identifier><identifier>PMID: 19109464</identifier><identifier>CODEN: JCMIDW</identifier><language>eng</language><publisher>Washington, DC: American Society for Microbiology</publisher><subject>Adult ; Biological and medical sciences ; Caliciviridae Infections ; Caliciviridae Infections - epidemiology ; Caliciviridae Infections - virology ; Child ; Child, Preschool ; Cluster Analysis ; Epidemiology ; Feces ; Feces - virology ; Fundamental and applied biological sciences. Psychology ; Gastroenteritis ; Gastroenteritis - epidemiology ; Gastroenteritis - virology ; Genetic Variation ; Humans ; Infant ; Infant, Newborn ; Life Sciences ; Microbiology ; Microbiology and Parasitology ; Miscellaneous ; Molecular Epidemiology ; Molecular Sequence Data ; Norovirus ; Norovirus - classification ; Norovirus - genetics ; Norovirus - isolation & purification ; Prevalence ; Reverse Transcriptase Polymerase Chain Reaction ; Reverse Transcriptase Polymerase Chain Reaction - methods ; RNA, Viral ; RNA, Viral - genetics ; Sequence Analysis, DNA ; Tunisia ; Tunisia - epidemiology ; Virology</subject><ispartof>Journal of Clinical Microbiology, 2009-02, Vol.47 (2), p.421-429</ispartof><rights>2009 INIST-CNRS</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><rights>Copyright © 2009, American Society for Microbiology</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c592t-8a2b0b325b810bb09b25dd142f4f0f006177a5253c6280d6b931515a381c0a433</citedby><cites>FETCH-LOGICAL-c592t-8a2b0b325b810bb09b25dd142f4f0f006177a5253c6280d6b931515a381c0a433</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2643701/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2643701/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,3174,3175,27903,27904,53769,53771</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21173168$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19109464$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.science/hal-00465365$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Sdiri-Loulizi, Khira</creatorcontrib><creatorcontrib>Ambert-Balay, Katia</creatorcontrib><creatorcontrib>Gharbi-Khelifi, Hakima</creatorcontrib><creatorcontrib>Sakly, Nabil</creatorcontrib><creatorcontrib>Hassine, Mouna</creatorcontrib><creatorcontrib>Chouchane, Slaheddine</creatorcontrib><creatorcontrib>Guediche, Mohamed Neji</creatorcontrib><creatorcontrib>Pothier, Pierre</creatorcontrib><creatorcontrib>Aouni, Mahjoub</creatorcontrib><title>Molecular Epidemiology of Norovirus Gastroenteritis Investigated Using Samples Collected from Children in Tunisia during a Four-Year Period: Detection of the Norovirus Variant GGII.4 Hunter as Early as January 2003</title><title>Journal of Clinical Microbiology</title><addtitle>J Clin Microbiol</addtitle><description>Human noroviruses (NoVs) cause epidemic and endemic acute gastroenteritis in children and adults. To study the prevalence and genetic diversity of NoV in children in Tunisia, a total of 788 fecal samples were collected during a 4-year period in the region of Monastir, from children 12 years of age or younger, hospitalized or presenting in dispensaries with symptoms of acute gastroenteritis. NoV was detected by reverse transcription-PCR and confirmed by sequence analysis. This is the first report that describes the molecular epidemiology of NoV in Tunisian children: NoVs were characterized as the causative agent in 128 (16.2%) of the samples. Fourteen samples contained a mixture of two NoVs, and 33 samples were coinfected with additional enteric viruses. Eight distinct NoV genotypes were detected (GGI.2, GGI.4, GGII.1, GGII.4, GGII.8, GGII.14, GGIIb/GGII.2, and GGIIb/GGII.3). GGII.4 was the most prevalent genotype, accounting for 83 (64.8%) cases. Interestingly the GGII.4 variant Hunter, described as spreading all over the world in 2004, was found in Tunisia as early as January 2003. The delay of 1 year between the isolation in Tunisia and the worldwide emergence is somewhat surprising, considering the importance of the contacts between North Africa and Europe particularly. Nevertheless, this illustrates the idea that sporadic gastroenteritis cases may be a reservoir for emerging epidemic NoV strains.</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Caliciviridae Infections</subject><subject>Caliciviridae Infections - epidemiology</subject><subject>Caliciviridae Infections - virology</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Cluster Analysis</subject><subject>Epidemiology</subject><subject>Feces</subject><subject>Feces - virology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gastroenteritis</subject><subject>Gastroenteritis - epidemiology</subject><subject>Gastroenteritis - virology</subject><subject>Genetic Variation</subject><subject>Humans</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Life Sciences</subject><subject>Microbiology</subject><subject>Microbiology and Parasitology</subject><subject>Miscellaneous</subject><subject>Molecular Epidemiology</subject><subject>Molecular Sequence Data</subject><subject>Norovirus</subject><subject>Norovirus - classification</subject><subject>Norovirus - genetics</subject><subject>Norovirus - isolation & purification</subject><subject>Prevalence</subject><subject>Reverse Transcriptase Polymerase Chain Reaction</subject><subject>Reverse Transcriptase Polymerase Chain Reaction - methods</subject><subject>RNA, Viral</subject><subject>RNA, Viral - genetics</subject><subject>Sequence Analysis, DNA</subject><subject>Tunisia</subject><subject>Tunisia - epidemiology</subject><subject>Virology</subject><issn>0095-1137</issn><issn>1098-660X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkk9v0zAYxiMEYmNw4wy-gIREyms7dpIdkKbSdZ06QNqG4GS9SZzWUxIXOynaF-Xz4NBqDC6cbNm_93n_PVH0nMKEUpa9uynbCdBMsBiyB9EhhTyLpYSvD6NDgFzElPL0IHri_Q0ATRIhHkcHNA9YIpPD6OeFbXQ5NOjIbGMq3Rrb2NUtsTX5aJ3dGjd4MkffO6u7XjvTG08W3Vb73qyw1xW59qZbkUtsN432ZGqboDe-1862ZLo2TeV0R0xHrobOeIOkGtwYgeTUDi7-pkPqz0HYVsfkg-5DsLHdmL9f63s1fEFnsOvJfL5YTBJyNozVEPRkhq65HS_n2A3obgkD4E-jRzU2Xj_bn0fR9ensanoWLz_NF9OTZVyKnPVxhqyAgjNRZBSKAvKCiaqiCauTGmoASdMUBRO8lCyDShY5p4IK5BktARPOj6L3O93NULS6KsOMHDZq40wbSlEWjfr7pzNrtbJbxWTCU6BB4M1OYP1P2NnJUo1vAIkUXIrtyL7eJ3P2-xA2oFrjS9002Gk7eCVllmWUyf-CjPLgjBQC-HYHls5673R9VwIFNbpLnU8v1G93KcgC_uJ-t3_gvZ0C8GoPoC-xqR12pfF3HKM05VSOQmTftVmtfxinFfpWBSerJFVMJWxs9uUOqdEqXLkgc33JwsSAijxsOOW_AMfh7bM</recordid><startdate>20090201</startdate><enddate>20090201</enddate><creator>Sdiri-Loulizi, Khira</creator><creator>Ambert-Balay, Katia</creator><creator>Gharbi-Khelifi, Hakima</creator><creator>Sakly, Nabil</creator><creator>Hassine, Mouna</creator><creator>Chouchane, Slaheddine</creator><creator>Guediche, Mohamed Neji</creator><creator>Pothier, Pierre</creator><creator>Aouni, Mahjoub</creator><general>American Society for Microbiology</general><general>American Society for Microbiology (ASM)</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope><scope>1XC</scope><scope>5PM</scope></search><sort><creationdate>20090201</creationdate><title>Molecular Epidemiology of Norovirus Gastroenteritis Investigated Using Samples Collected from Children in Tunisia during a Four-Year Period: Detection of the Norovirus Variant GGII.4 Hunter as Early as January 2003</title><author>Sdiri-Loulizi, Khira ; Ambert-Balay, Katia ; Gharbi-Khelifi, Hakima ; Sakly, Nabil ; Hassine, Mouna ; Chouchane, Slaheddine ; Guediche, Mohamed Neji ; Pothier, Pierre ; Aouni, Mahjoub</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c592t-8a2b0b325b810bb09b25dd142f4f0f006177a5253c6280d6b931515a381c0a433</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Caliciviridae Infections</topic><topic>Caliciviridae Infections - epidemiology</topic><topic>Caliciviridae Infections - virology</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Cluster Analysis</topic><topic>Epidemiology</topic><topic>Feces</topic><topic>Feces - virology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gastroenteritis</topic><topic>Gastroenteritis - epidemiology</topic><topic>Gastroenteritis - virology</topic><topic>Genetic Variation</topic><topic>Humans</topic><topic>Infant</topic><topic>Infant, Newborn</topic><topic>Life Sciences</topic><topic>Microbiology</topic><topic>Microbiology and Parasitology</topic><topic>Miscellaneous</topic><topic>Molecular Epidemiology</topic><topic>Molecular Sequence Data</topic><topic>Norovirus</topic><topic>Norovirus - classification</topic><topic>Norovirus - genetics</topic><topic>Norovirus - isolation & purification</topic><topic>Prevalence</topic><topic>Reverse Transcriptase Polymerase Chain Reaction</topic><topic>Reverse Transcriptase Polymerase Chain Reaction - methods</topic><topic>RNA, Viral</topic><topic>RNA, Viral - genetics</topic><topic>Sequence Analysis, DNA</topic><topic>Tunisia</topic><topic>Tunisia - epidemiology</topic><topic>Virology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sdiri-Loulizi, Khira</creatorcontrib><creatorcontrib>Ambert-Balay, Katia</creatorcontrib><creatorcontrib>Gharbi-Khelifi, Hakima</creatorcontrib><creatorcontrib>Sakly, Nabil</creatorcontrib><creatorcontrib>Hassine, Mouna</creatorcontrib><creatorcontrib>Chouchane, Slaheddine</creatorcontrib><creatorcontrib>Guediche, Mohamed Neji</creatorcontrib><creatorcontrib>Pothier, Pierre</creatorcontrib><creatorcontrib>Aouni, Mahjoub</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of Clinical Microbiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sdiri-Loulizi, Khira</au><au>Ambert-Balay, Katia</au><au>Gharbi-Khelifi, Hakima</au><au>Sakly, Nabil</au><au>Hassine, Mouna</au><au>Chouchane, Slaheddine</au><au>Guediche, Mohamed Neji</au><au>Pothier, Pierre</au><au>Aouni, Mahjoub</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Molecular Epidemiology of Norovirus Gastroenteritis Investigated Using Samples Collected from Children in Tunisia during a Four-Year Period: Detection of the Norovirus Variant GGII.4 Hunter as Early as January 2003</atitle><jtitle>Journal of Clinical Microbiology</jtitle><addtitle>J Clin Microbiol</addtitle><date>2009-02-01</date><risdate>2009</risdate><volume>47</volume><issue>2</issue><spage>421</spage><epage>429</epage><pages>421-429</pages><issn>0095-1137</issn><eissn>1098-660X</eissn><coden>JCMIDW</coden><abstract>Human noroviruses (NoVs) cause epidemic and endemic acute gastroenteritis in children and adults. To study the prevalence and genetic diversity of NoV in children in Tunisia, a total of 788 fecal samples were collected during a 4-year period in the region of Monastir, from children 12 years of age or younger, hospitalized or presenting in dispensaries with symptoms of acute gastroenteritis. NoV was detected by reverse transcription-PCR and confirmed by sequence analysis. This is the first report that describes the molecular epidemiology of NoV in Tunisian children: NoVs were characterized as the causative agent in 128 (16.2%) of the samples. Fourteen samples contained a mixture of two NoVs, and 33 samples were coinfected with additional enteric viruses. Eight distinct NoV genotypes were detected (GGI.2, GGI.4, GGII.1, GGII.4, GGII.8, GGII.14, GGIIb/GGII.2, and GGIIb/GGII.3). GGII.4 was the most prevalent genotype, accounting for 83 (64.8%) cases. Interestingly the GGII.4 variant Hunter, described as spreading all over the world in 2004, was found in Tunisia as early as January 2003. The delay of 1 year between the isolation in Tunisia and the worldwide emergence is somewhat surprising, considering the importance of the contacts between North Africa and Europe particularly. Nevertheless, this illustrates the idea that sporadic gastroenteritis cases may be a reservoir for emerging epidemic NoV strains.</abstract><cop>Washington, DC</cop><pub>American Society for Microbiology</pub><pmid>19109464</pmid><doi>10.1128/jcm.01852-08</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of Clinical Microbiology, 2009-02, Vol.47 (2), p.421-429 |
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| source | American Society for Microbiology; MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | Adult Biological and medical sciences Caliciviridae Infections Caliciviridae Infections - epidemiology Caliciviridae Infections - virology Child Child, Preschool Cluster Analysis Epidemiology Feces Feces - virology Fundamental and applied biological sciences. Psychology Gastroenteritis Gastroenteritis - epidemiology Gastroenteritis - virology Genetic Variation Humans Infant Infant, Newborn Life Sciences Microbiology Microbiology and Parasitology Miscellaneous Molecular Epidemiology Molecular Sequence Data Norovirus Norovirus - classification Norovirus - genetics Norovirus - isolation & purification Prevalence Reverse Transcriptase Polymerase Chain Reaction Reverse Transcriptase Polymerase Chain Reaction - methods RNA, Viral RNA, Viral - genetics Sequence Analysis, DNA Tunisia Tunisia - epidemiology Virology |
| title | Molecular Epidemiology of Norovirus Gastroenteritis Investigated Using Samples Collected from Children in Tunisia during a Four-Year Period: Detection of the Norovirus Variant GGII.4 Hunter as Early as January 2003 |
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