Analgesic and anti-inflammatory effects of Cassia siamea Lam. stem bark extracts
The present study was carried out to investigate analgesic and anti-inflammatory activities of Cassia siamea Lam stem bark extracts. We have also determined the cytotoxicity of each extract. C. siamea, a widespread medicinal plant traditionally used in sub-Saharan Africa, was collected in Congo Braz...
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| Veröffentlicht in: | Journal of ethnopharmacology 2010-01, Vol.127 (1), p.108-111 |
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| creator | Nsonde Ntandou, G.F. Banzouzi, J.T. Mbatchi, B. Elion-Itou, R.D.G. Etou-Ossibi, A.W. Ramos, S. Benoit-Vical, F. Abena, A.A. Ouamba, J.M. |
| description | The present study was carried out to investigate analgesic and anti-inflammatory activities of
Cassia siamea Lam stem bark extracts. We have also determined the cytotoxicity of each extract.
C. siamea, a widespread medicinal plant traditionally used in sub-Saharan Africa, was collected in Congo Brazzaville. Stem bark was extracted with petroleum ether (CSE1), chloroform (CSE2), ethanol (CSE3) and water (CSE4). Analgesic, anti-inflammatory and antipyretic activities of these extracts were assessed in rats with hot plate test, paw pressure and carrageenan induced paw oedema. Cytotoxicity was assessed against KB and Vero cells.
At the doses used (100, 200, and 400
mg/kg) ethanol and water extracts showed significant and dose-dependent analgesic and anti-inflammatory effects. None of the extracts had cytotoxic activity on KB and Vero cell lines and the most active extracts (CSE3 and CSE4) had no acute toxicity.
The study highlighted the analgesic and anti-inflammatory of
C. siamea stem bark. Four major families of compounds present in the plant may explain these activities: triterpenes (lupeol, oleanolic acid, ursolic acid, friedelin, betulin), flavonoids (apigenin, kaempferol, luteolin), anthraquinones (emodin), phytosterols (stigmasterol, beta-sitosterol). |
| doi_str_mv | 10.1016/j.jep.2009.09.040 |
| format | Article |
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Cassia siamea Lam stem bark extracts. We have also determined the cytotoxicity of each extract.
C. siamea, a widespread medicinal plant traditionally used in sub-Saharan Africa, was collected in Congo Brazzaville. Stem bark was extracted with petroleum ether (CSE1), chloroform (CSE2), ethanol (CSE3) and water (CSE4). Analgesic, anti-inflammatory and antipyretic activities of these extracts were assessed in rats with hot plate test, paw pressure and carrageenan induced paw oedema. Cytotoxicity was assessed against KB and Vero cells.
At the doses used (100, 200, and 400
mg/kg) ethanol and water extracts showed significant and dose-dependent analgesic and anti-inflammatory effects. None of the extracts had cytotoxic activity on KB and Vero cell lines and the most active extracts (CSE3 and CSE4) had no acute toxicity.
The study highlighted the analgesic and anti-inflammatory of
C. siamea stem bark. Four major families of compounds present in the plant may explain these activities: triterpenes (lupeol, oleanolic acid, ursolic acid, friedelin, betulin), flavonoids (apigenin, kaempferol, luteolin), anthraquinones (emodin), phytosterols (stigmasterol, beta-sitosterol).</description><identifier>ISSN: 0378-8741</identifier><identifier>EISSN: 1872-7573</identifier><identifier>DOI: 10.1016/j.jep.2009.09.040</identifier><identifier>PMID: 19799981</identifier><identifier>CODEN: JOETD7</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>acute toxicity ; Analgesic ; analgesic effect ; Analgesics, Non-Narcotic - pharmacology ; Analgesics, Non-Narcotic - toxicity ; animal models ; Animals ; anthraquinones ; Anti-inflammatory ; anti-inflammatory activity ; Anti-Inflammatory Agents, Non-Steroidal - pharmacology ; Anti-Inflammatory Agents, Non-Steroidal - toxicity ; Antipyretic ; antipyretics ; bark ; Biological and medical sciences ; Cassia siamea ; cell lines ; Cercopithecus aethiops ; Chemical Sciences ; Congo ; cultured cells ; cytotoxicity ; dosage ; dose response ; Dose-Response Relationship, Drug ; Edema - chemically induced ; Edema - prevention & control ; Fabaceae ; Female ; flavonoids ; General pharmacology ; Humans ; KB Cells ; Lethal Dose 50 ; Male ; Medical sciences ; medicinal plants ; medicinal properties ; Medicine, Traditional ; Organic chemistry ; Pharmacognosy. Homeopathy. Health food ; Pharmacology. Drug treatments ; phytosterols ; Phytotherapy ; Plant Bark - chemistry ; plant extracts ; Plant Extracts - pharmacology ; Plant Extracts - toxicity ; Plants, Medicinal ; Random Allocation ; Rats ; Rats, Wistar ; Senna Plant - chemistry ; Senna siamea ; solvents ; Stem bark extracts ; triterpenoids ; Vero Cells</subject><ispartof>Journal of ethnopharmacology, 2010-01, Vol.127 (1), p.108-111</ispartof><rights>2009 Elsevier Ireland Ltd</rights><rights>2015 INIST-CNRS</rights><rights>Copyright 2009 Elsevier Ireland Ltd. All rights reserved.</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c506t-c27554ec928c63bd93fe73f34754c1ff5e4c3f3ee0763806e6e0d21d8fcfb9413</citedby><cites>FETCH-LOGICAL-c506t-c27554ec928c63bd93fe73f34754c1ff5e4c3f3ee0763806e6e0d21d8fcfb9413</cites><orcidid>0000-0002-9468-4823</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S037887410900600X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,776,780,881,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22473599$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19799981$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.science/hal-00464258$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Nsonde Ntandou, G.F.</creatorcontrib><creatorcontrib>Banzouzi, J.T.</creatorcontrib><creatorcontrib>Mbatchi, B.</creatorcontrib><creatorcontrib>Elion-Itou, R.D.G.</creatorcontrib><creatorcontrib>Etou-Ossibi, A.W.</creatorcontrib><creatorcontrib>Ramos, S.</creatorcontrib><creatorcontrib>Benoit-Vical, F.</creatorcontrib><creatorcontrib>Abena, A.A.</creatorcontrib><creatorcontrib>Ouamba, J.M.</creatorcontrib><title>Analgesic and anti-inflammatory effects of Cassia siamea Lam. stem bark extracts</title><title>Journal of ethnopharmacology</title><addtitle>J Ethnopharmacol</addtitle><description>The present study was carried out to investigate analgesic and anti-inflammatory activities of
Cassia siamea Lam stem bark extracts. We have also determined the cytotoxicity of each extract.
C. siamea, a widespread medicinal plant traditionally used in sub-Saharan Africa, was collected in Congo Brazzaville. Stem bark was extracted with petroleum ether (CSE1), chloroform (CSE2), ethanol (CSE3) and water (CSE4). Analgesic, anti-inflammatory and antipyretic activities of these extracts were assessed in rats with hot plate test, paw pressure and carrageenan induced paw oedema. Cytotoxicity was assessed against KB and Vero cells.
At the doses used (100, 200, and 400
mg/kg) ethanol and water extracts showed significant and dose-dependent analgesic and anti-inflammatory effects. None of the extracts had cytotoxic activity on KB and Vero cell lines and the most active extracts (CSE3 and CSE4) had no acute toxicity.
The study highlighted the analgesic and anti-inflammatory of
C. siamea stem bark. Four major families of compounds present in the plant may explain these activities: triterpenes (lupeol, oleanolic acid, ursolic acid, friedelin, betulin), flavonoids (apigenin, kaempferol, luteolin), anthraquinones (emodin), phytosterols (stigmasterol, beta-sitosterol).</description><subject>acute toxicity</subject><subject>Analgesic</subject><subject>analgesic effect</subject><subject>Analgesics, Non-Narcotic - pharmacology</subject><subject>Analgesics, Non-Narcotic - toxicity</subject><subject>animal models</subject><subject>Animals</subject><subject>anthraquinones</subject><subject>Anti-inflammatory</subject><subject>anti-inflammatory activity</subject><subject>Anti-Inflammatory Agents, Non-Steroidal - pharmacology</subject><subject>Anti-Inflammatory Agents, Non-Steroidal - toxicity</subject><subject>Antipyretic</subject><subject>antipyretics</subject><subject>bark</subject><subject>Biological and medical sciences</subject><subject>Cassia siamea</subject><subject>cell lines</subject><subject>Cercopithecus aethiops</subject><subject>Chemical Sciences</subject><subject>Congo</subject><subject>cultured cells</subject><subject>cytotoxicity</subject><subject>dosage</subject><subject>dose response</subject><subject>Dose-Response Relationship, Drug</subject><subject>Edema - chemically induced</subject><subject>Edema - prevention & control</subject><subject>Fabaceae</subject><subject>Female</subject><subject>flavonoids</subject><subject>General pharmacology</subject><subject>Humans</subject><subject>KB Cells</subject><subject>Lethal Dose 50</subject><subject>Male</subject><subject>Medical sciences</subject><subject>medicinal plants</subject><subject>medicinal properties</subject><subject>Medicine, Traditional</subject><subject>Organic chemistry</subject><subject>Pharmacognosy. Homeopathy. Health food</subject><subject>Pharmacology. Drug treatments</subject><subject>phytosterols</subject><subject>Phytotherapy</subject><subject>Plant Bark - chemistry</subject><subject>plant extracts</subject><subject>Plant Extracts - pharmacology</subject><subject>Plant Extracts - toxicity</subject><subject>Plants, Medicinal</subject><subject>Random Allocation</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Senna Plant - chemistry</subject><subject>Senna siamea</subject><subject>solvents</subject><subject>Stem bark extracts</subject><subject>triterpenoids</subject><subject>Vero Cells</subject><issn>0378-8741</issn><issn>1872-7573</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE2LFDEQhoMo7uzqD_CiffGwh24rH93p4GkY1BUGFHTPoSZdWTP2x5D0Lu6_N00P602ookjxvEV4GHvDoeLAmw_H6kinSgCYaikFz9iGt1qUutbyOduA1G3ZasUv2GVKRwDQXMFLdsGNNsa0fMO-b0fs7ygFV-DY5Z5DGUbf4zDgPMXHgrwnN6di8sUOUwpY5B4Iiz0OVZFmGooDxt8F_ZkjZvAVe-GxT_T6PK_Y7edPP3c35f7bl6-77b50NTRz6YSua0XOiNY18tAZ6UlLL5WulePe16RcfhKBbmQLDTUEneBd650_GMXlFbte7_7C3p5iGDA-2gmDvdnu7bIDUI0SdfuwsHxlXZxSiuSfAhzsYtIebTZpF5N2KQU583bNnO4PA3X_Emd1GXh_BjA57H3E0YX0xAmhtKyNydy7lfM4WbyLmbn9IYBL4FqAgDYTH1eCsq-HQNEmF2h01IWY3dtuCv_56F9pdZj7</recordid><startdate>201001</startdate><enddate>201001</enddate><creator>Nsonde Ntandou, G.F.</creator><creator>Banzouzi, J.T.</creator><creator>Mbatchi, B.</creator><creator>Elion-Itou, R.D.G.</creator><creator>Etou-Ossibi, A.W.</creator><creator>Ramos, S.</creator><creator>Benoit-Vical, F.</creator><creator>Abena, A.A.</creator><creator>Ouamba, J.M.</creator><general>Elsevier Ireland Ltd</general><general>Amsterdam; New York: Elsevier</general><general>Elsevier</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>1XC</scope><orcidid>https://orcid.org/0000-0002-9468-4823</orcidid></search><sort><creationdate>201001</creationdate><title>Analgesic and anti-inflammatory effects of Cassia siamea Lam. stem bark extracts</title><author>Nsonde Ntandou, G.F. ; Banzouzi, J.T. ; Mbatchi, B. ; Elion-Itou, R.D.G. ; Etou-Ossibi, A.W. ; Ramos, S. ; Benoit-Vical, F. ; Abena, A.A. ; Ouamba, J.M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c506t-c27554ec928c63bd93fe73f34754c1ff5e4c3f3ee0763806e6e0d21d8fcfb9413</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>acute toxicity</topic><topic>Analgesic</topic><topic>analgesic effect</topic><topic>Analgesics, Non-Narcotic - pharmacology</topic><topic>Analgesics, Non-Narcotic - toxicity</topic><topic>animal models</topic><topic>Animals</topic><topic>anthraquinones</topic><topic>Anti-inflammatory</topic><topic>anti-inflammatory activity</topic><topic>Anti-Inflammatory Agents, Non-Steroidal - pharmacology</topic><topic>Anti-Inflammatory Agents, Non-Steroidal - toxicity</topic><topic>Antipyretic</topic><topic>antipyretics</topic><topic>bark</topic><topic>Biological and medical sciences</topic><topic>Cassia siamea</topic><topic>cell lines</topic><topic>Cercopithecus aethiops</topic><topic>Chemical Sciences</topic><topic>Congo</topic><topic>cultured cells</topic><topic>cytotoxicity</topic><topic>dosage</topic><topic>dose response</topic><topic>Dose-Response Relationship, Drug</topic><topic>Edema - chemically induced</topic><topic>Edema - prevention & control</topic><topic>Fabaceae</topic><topic>Female</topic><topic>flavonoids</topic><topic>General pharmacology</topic><topic>Humans</topic><topic>KB Cells</topic><topic>Lethal Dose 50</topic><topic>Male</topic><topic>Medical sciences</topic><topic>medicinal plants</topic><topic>medicinal properties</topic><topic>Medicine, Traditional</topic><topic>Organic chemistry</topic><topic>Pharmacognosy. Homeopathy. Health food</topic><topic>Pharmacology. Drug treatments</topic><topic>phytosterols</topic><topic>Phytotherapy</topic><topic>Plant Bark - chemistry</topic><topic>plant extracts</topic><topic>Plant Extracts - pharmacology</topic><topic>Plant Extracts - toxicity</topic><topic>Plants, Medicinal</topic><topic>Random Allocation</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Senna Plant - chemistry</topic><topic>Senna siamea</topic><topic>solvents</topic><topic>Stem bark extracts</topic><topic>triterpenoids</topic><topic>Vero Cells</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nsonde Ntandou, G.F.</creatorcontrib><creatorcontrib>Banzouzi, J.T.</creatorcontrib><creatorcontrib>Mbatchi, B.</creatorcontrib><creatorcontrib>Elion-Itou, R.D.G.</creatorcontrib><creatorcontrib>Etou-Ossibi, A.W.</creatorcontrib><creatorcontrib>Ramos, S.</creatorcontrib><creatorcontrib>Benoit-Vical, F.</creatorcontrib><creatorcontrib>Abena, A.A.</creatorcontrib><creatorcontrib>Ouamba, J.M.</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Hyper Article en Ligne (HAL)</collection><jtitle>Journal of ethnopharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nsonde Ntandou, G.F.</au><au>Banzouzi, J.T.</au><au>Mbatchi, B.</au><au>Elion-Itou, R.D.G.</au><au>Etou-Ossibi, A.W.</au><au>Ramos, S.</au><au>Benoit-Vical, F.</au><au>Abena, A.A.</au><au>Ouamba, J.M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Analgesic and anti-inflammatory effects of Cassia siamea Lam. stem bark extracts</atitle><jtitle>Journal of ethnopharmacology</jtitle><addtitle>J Ethnopharmacol</addtitle><date>2010-01</date><risdate>2010</risdate><volume>127</volume><issue>1</issue><spage>108</spage><epage>111</epage><pages>108-111</pages><issn>0378-8741</issn><eissn>1872-7573</eissn><coden>JOETD7</coden><abstract>The present study was carried out to investigate analgesic and anti-inflammatory activities of
Cassia siamea Lam stem bark extracts. We have also determined the cytotoxicity of each extract.
C. siamea, a widespread medicinal plant traditionally used in sub-Saharan Africa, was collected in Congo Brazzaville. Stem bark was extracted with petroleum ether (CSE1), chloroform (CSE2), ethanol (CSE3) and water (CSE4). Analgesic, anti-inflammatory and antipyretic activities of these extracts were assessed in rats with hot plate test, paw pressure and carrageenan induced paw oedema. Cytotoxicity was assessed against KB and Vero cells.
At the doses used (100, 200, and 400
mg/kg) ethanol and water extracts showed significant and dose-dependent analgesic and anti-inflammatory effects. None of the extracts had cytotoxic activity on KB and Vero cell lines and the most active extracts (CSE3 and CSE4) had no acute toxicity.
The study highlighted the analgesic and anti-inflammatory of
C. siamea stem bark. Four major families of compounds present in the plant may explain these activities: triterpenes (lupeol, oleanolic acid, ursolic acid, friedelin, betulin), flavonoids (apigenin, kaempferol, luteolin), anthraquinones (emodin), phytosterols (stigmasterol, beta-sitosterol).</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>19799981</pmid><doi>10.1016/j.jep.2009.09.040</doi><tpages>4</tpages><orcidid>https://orcid.org/0000-0002-9468-4823</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0378-8741 |
| ispartof | Journal of ethnopharmacology, 2010-01, Vol.127 (1), p.108-111 |
| issn | 0378-8741 1872-7573 |
| language | eng |
| recordid | cdi_hal_primary_oai_HAL_hal_00464258v1 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | acute toxicity Analgesic analgesic effect Analgesics, Non-Narcotic - pharmacology Analgesics, Non-Narcotic - toxicity animal models Animals anthraquinones Anti-inflammatory anti-inflammatory activity Anti-Inflammatory Agents, Non-Steroidal - pharmacology Anti-Inflammatory Agents, Non-Steroidal - toxicity Antipyretic antipyretics bark Biological and medical sciences Cassia siamea cell lines Cercopithecus aethiops Chemical Sciences Congo cultured cells cytotoxicity dosage dose response Dose-Response Relationship, Drug Edema - chemically induced Edema - prevention & control Fabaceae Female flavonoids General pharmacology Humans KB Cells Lethal Dose 50 Male Medical sciences medicinal plants medicinal properties Medicine, Traditional Organic chemistry Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments phytosterols Phytotherapy Plant Bark - chemistry plant extracts Plant Extracts - pharmacology Plant Extracts - toxicity Plants, Medicinal Random Allocation Rats Rats, Wistar Senna Plant - chemistry Senna siamea solvents Stem bark extracts triterpenoids Vero Cells |
| title | Analgesic and anti-inflammatory effects of Cassia siamea Lam. stem bark extracts |
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