Constitutive expression of suppressor of cytokine signalling-3 in skeletal muscle leads to reduced mobility and overweight in mice

Aims/hypothesis Due to their ability to regulate various signalling pathways (cytokines, hormones, growth factors), the suppressor of cytokine signalling (SOCS) proteins are thought to be promising therapeutic targets for metabolic and inflammatory disorders. Hence, their role in vivo has to be prec...

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Veröffentlicht in:	Diabetologia 2009-10, Vol.52 (10), p.2201-2212
Hauptverfasser:	Lebrun, P, Cognard, E, Bellon-Paul, R, Gontard, P, Filloux, C, Jehl-Pietri, C, Grimaldi, P, Samson, M, Pénicaud, L, Ruberte, J, Ferre, T, Pujol, A, Bosch, F, Van Obberghen, E
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Calcineurin - metabolism Calorimetry Diabetes. Impaired glucose tolerance Endocrine pancreas. Apud cells (diseases) Endocrinology and metabolism Endocrinopathies Etiopathogenesis. Screening. Investigations. Target tissue resistance Fundamental and applied biological sciences. Psychology Human health and pathology Human Physiology In Vitro Techniques Insulin - metabolism Internal Medicine Life Sciences Medical sciences Medicine Medicine & Public Health Metabolic Diseases Mice Mice, Transgenic Motor Activity - genetics Motor Activity - physiology Muscle, Skeletal - cytology Muscle, Skeletal - metabolism Muscle, Skeletal - physiology Obesity Oligonucleotide Array Sequence Analysis Overweight - genetics Protein Binding Reverse Transcriptase Polymerase Chain Reaction Signal Transduction - genetics Signal Transduction - physiology Striated muscle. Tendons Suppressor of Cytokine Signaling 3 Protein Suppressor of Cytokine Signaling Proteins - genetics Suppressor of Cytokine Signaling Proteins - metabolism Suppressor of Cytokine Signaling Proteins - physiology Vertebrates: osteoarticular system, musculoskeletal system
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