The cognitive and neural expression of semantic memory impairment in mild cognitive impairment and early Alzheimer's disease
Semantic deficits in Alzheimer's disease have been widely documented, but little is known about the integrity of semantic memory in the prodromal stage of the illness. The aims of the present study were to: (i) investigate naming abilities and semantic memory in amnestic mild cognitive impairme...
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| Veröffentlicht in: | Neuropsychologia 2010-03, Vol.48 (4), p.978-988 |
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| creator | Joubert, Sven Brambati, Simona M. Ansado, Jennyfer Barbeau, Emmanuel J. Felician, Olivier Didic, Mira Lacombe, Jacinthe Goldstein, Rachel Chayer, Céline Kergoat, Marie-Jeanne |
| description | Semantic deficits in Alzheimer's disease have been widely documented, but little is known about the integrity of semantic memory in the prodromal stage of the illness. The aims of the present study were to: (i) investigate naming abilities and semantic memory in amnestic mild cognitive impairment (aMCI), early Alzheimer's disease (AD) compared to healthy older subjects; (ii) investigate the association between naming and semantic knowledge in aMCI and AD; (iii) examine if the semantic impairment was present in different modalities; and (iv) study the relationship between semantic performance and grey matter volume using voxel-based morphometry. Results indicate that both naming and semantic knowledge of objects and famous people were impaired in aMCI and early AD groups, when compared to healthy age- and education-matched controls. Item-by-item analyses showed that anomia in aMCI and early AD was significantly associated with underlying semantic knowledge of famous people but not with semantic knowledge of objects. Moreover, semantic knowledge of the same concepts was impaired in both the visual and the verbal modalities. Finally, voxel-based morphometry analyses revealed that semantic impairment in aMCI and AD was associated with cortical atrophy in the anterior temporal lobe (ATL) region as well as in the inferior prefrontal cortex (IPC), some of the key regions of the semantic cognition network. These findings suggest that the semantic impairment in aMCI may result from a breakdown of semantic knowledge of famous people and objects, combined with difficulties in the selection, manipulation and retrieval of this knowledge. |
| doi_str_mv | 10.1016/j.neuropsychologia.2009.11.019 |
| format | Article |
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The aims of the present study were to: (i) investigate naming abilities and semantic memory in amnestic mild cognitive impairment (aMCI), early Alzheimer's disease (AD) compared to healthy older subjects; (ii) investigate the association between naming and semantic knowledge in aMCI and AD; (iii) examine if the semantic impairment was present in different modalities; and (iv) study the relationship between semantic performance and grey matter volume using voxel-based morphometry. Results indicate that both naming and semantic knowledge of objects and famous people were impaired in aMCI and early AD groups, when compared to healthy age- and education-matched controls. Item-by-item analyses showed that anomia in aMCI and early AD was significantly associated with underlying semantic knowledge of famous people but not with semantic knowledge of objects. Moreover, semantic knowledge of the same concepts was impaired in both the visual and the verbal modalities. Finally, voxel-based morphometry analyses revealed that semantic impairment in aMCI and AD was associated with cortical atrophy in the anterior temporal lobe (ATL) region as well as in the inferior prefrontal cortex (IPC), some of the key regions of the semantic cognition network. These findings suggest that the semantic impairment in aMCI may result from a breakdown of semantic knowledge of famous people and objects, combined with difficulties in the selection, manipulation and retrieval of this knowledge.</description><identifier>ISSN: 0028-3932</identifier><identifier>EISSN: 1873-3514</identifier><identifier>DOI: 10.1016/j.neuropsychologia.2009.11.019</identifier><identifier>PMID: 19954747</identifier><identifier>CODEN: NUPSA6</identifier><language>eng</language><publisher>Kidlington: Elsevier Ltd</publisher><subject>Adult and adolescent clinical studies ; Aged ; Aged, 80 and over ; Alzheimer Disease - psychology ; Alzheimer's disease ; Alzheimers Disease ; Anomia - psychology ; Biological and medical sciences ; Brain - pathology ; Brain - physiopathology ; Brain Hemisphere Functions ; Cognition ; Cognition Disorders - psychology ; Comparative Analysis ; Control Groups ; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases ; Diseases ; Female ; Geriatrics ; Humans ; Integrity ; Language Tests ; Life Sciences ; Male ; Medical sciences ; Memory ; Memory Disorders - psychology ; Mental Retardation ; Mild cognitive impairment ; Naming ; Neurological Impairments ; Neurology ; Neurons and Cognition ; Neuropsychological Tests ; Older Adults ; Organic mental disorders. Neuropsychology ; Prefrontal Cortex - pathology ; Prefrontal Cortex - physiopathology ; Psychology. Psychoanalysis. Psychiatry ; Psychomotor Performance ; Psychopathology. Psychiatry ; Semantic memory ; Semantics ; Semiotics ; Severity of Illness Index ; Temporal Lobe - pathology ; Temporal Lobe - physiopathology ; Verbal Behavior</subject><ispartof>Neuropsychologia, 2010-03, Vol.48 (4), p.978-988</ispartof><rights>2009 Elsevier Ltd</rights><rights>2015 INIST-CNRS</rights><rights>Copyright (c) 2009 Elsevier Ltd. All rights reserved.</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c476t-7891cf95fc29bc0582832a0d58f6d1451cf1fa6e344b0e033e605f6551a889533</citedby><cites>FETCH-LOGICAL-c476t-7891cf95fc29bc0582832a0d58f6d1451cf1fa6e344b0e033e605f6551a889533</cites><orcidid>0000-0003-0836-3538 ; 0000-0001-7067-536X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0028393209004515$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,776,780,881,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://eric.ed.gov/ERICWebPortal/detail?accno=EJ877784$$DView record in ERIC$$Hfree_for_read</backlink><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22796675$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19954747$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.science/hal-00459877$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Joubert, Sven</creatorcontrib><creatorcontrib>Brambati, Simona M.</creatorcontrib><creatorcontrib>Ansado, Jennyfer</creatorcontrib><creatorcontrib>Barbeau, Emmanuel J.</creatorcontrib><creatorcontrib>Felician, Olivier</creatorcontrib><creatorcontrib>Didic, Mira</creatorcontrib><creatorcontrib>Lacombe, Jacinthe</creatorcontrib><creatorcontrib>Goldstein, Rachel</creatorcontrib><creatorcontrib>Chayer, Céline</creatorcontrib><creatorcontrib>Kergoat, Marie-Jeanne</creatorcontrib><title>The cognitive and neural expression of semantic memory impairment in mild cognitive impairment and early Alzheimer's disease</title><title>Neuropsychologia</title><addtitle>Neuropsychologia</addtitle><description>Semantic deficits in Alzheimer's disease have been widely documented, but little is known about the integrity of semantic memory in the prodromal stage of the illness. The aims of the present study were to: (i) investigate naming abilities and semantic memory in amnestic mild cognitive impairment (aMCI), early Alzheimer's disease (AD) compared to healthy older subjects; (ii) investigate the association between naming and semantic knowledge in aMCI and AD; (iii) examine if the semantic impairment was present in different modalities; and (iv) study the relationship between semantic performance and grey matter volume using voxel-based morphometry. Results indicate that both naming and semantic knowledge of objects and famous people were impaired in aMCI and early AD groups, when compared to healthy age- and education-matched controls. Item-by-item analyses showed that anomia in aMCI and early AD was significantly associated with underlying semantic knowledge of famous people but not with semantic knowledge of objects. Moreover, semantic knowledge of the same concepts was impaired in both the visual and the verbal modalities. Finally, voxel-based morphometry analyses revealed that semantic impairment in aMCI and AD was associated with cortical atrophy in the anterior temporal lobe (ATL) region as well as in the inferior prefrontal cortex (IPC), some of the key regions of the semantic cognition network. These findings suggest that the semantic impairment in aMCI may result from a breakdown of semantic knowledge of famous people and objects, combined with difficulties in the selection, manipulation and retrieval of this knowledge.</description><subject>Adult and adolescent clinical studies</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Alzheimer Disease - psychology</subject><subject>Alzheimer's disease</subject><subject>Alzheimers Disease</subject><subject>Anomia - psychology</subject><subject>Biological and medical sciences</subject><subject>Brain - pathology</subject><subject>Brain - physiopathology</subject><subject>Brain Hemisphere Functions</subject><subject>Cognition</subject><subject>Cognition Disorders - psychology</subject><subject>Comparative Analysis</subject><subject>Control Groups</subject><subject>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</subject><subject>Diseases</subject><subject>Female</subject><subject>Geriatrics</subject><subject>Humans</subject><subject>Integrity</subject><subject>Language Tests</subject><subject>Life Sciences</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Memory</subject><subject>Memory Disorders - psychology</subject><subject>Mental Retardation</subject><subject>Mild cognitive impairment</subject><subject>Naming</subject><subject>Neurological Impairments</subject><subject>Neurology</subject><subject>Neurons and Cognition</subject><subject>Neuropsychological Tests</subject><subject>Older Adults</subject><subject>Organic mental disorders. Neuropsychology</subject><subject>Prefrontal Cortex - pathology</subject><subject>Prefrontal Cortex - physiopathology</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychomotor Performance</subject><subject>Psychopathology. Psychiatry</subject><subject>Semantic memory</subject><subject>Semantics</subject><subject>Semiotics</subject><subject>Severity of Illness Index</subject><subject>Temporal Lobe - pathology</subject><subject>Temporal Lobe - physiopathology</subject><subject>Verbal Behavior</subject><issn>0028-3932</issn><issn>1873-3514</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkU-LEzEYhwdR3Lr6DURy0cXD1PyZTJKLUJbVKgUv6zmkmXe2KZNkTKbFih_eGTrUxZOnQH5PniTvryjeEbwkmNQf9ssAhxT7fLK72MUHZ5YUY7UkZImJelIsiBSsZJxUT4sFxlSWTDF6VbzIeY8xrjiVz4srohSvRCUWxe_7HSAbH4Ib3BGQCQ2aLjAdgp99gpxdDCi2KIM3YXAWefAxnZDzvXHJQxiQC8i7rnlkeRROQjCpO6FV92sHzkO6yahxGUyGl8Wz1nQZXs3rdfH909397brcfPv85Xa1KW0l6qEUUhHbKt5aqrYWc0klowY3XLZ1Qyo-hqQ1NbCq2mLAjEGNeVtzToyUijN2Xbw_e3em031y3qSTjsbp9Wqjp71pMEoKcSQje3Nm-xR_HCAP2rtsoetMgHjIWjBGqaJksn48kzbFnBO0FzXBeipL7_W_ZempLE2IHssaBW_mqw5bD83f43M7I_B2Bky2pmuTCdblC0epUHUt-Mi9PnOQnL3Ed1_HHwlZjfF6jscZHx0kna2DYKFxCeygm-j-98l_APJhx_w</recordid><startdate>20100301</startdate><enddate>20100301</enddate><creator>Joubert, Sven</creator><creator>Brambati, Simona M.</creator><creator>Ansado, Jennyfer</creator><creator>Barbeau, Emmanuel J.</creator><creator>Felician, Olivier</creator><creator>Didic, Mira</creator><creator>Lacombe, Jacinthe</creator><creator>Goldstein, Rachel</creator><creator>Chayer, Céline</creator><creator>Kergoat, Marie-Jeanne</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>7SW</scope><scope>BJH</scope><scope>BNH</scope><scope>BNI</scope><scope>BNJ</scope><scope>BNO</scope><scope>ERI</scope><scope>PET</scope><scope>REK</scope><scope>WWN</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>1XC</scope><orcidid>https://orcid.org/0000-0003-0836-3538</orcidid><orcidid>https://orcid.org/0000-0001-7067-536X</orcidid></search><sort><creationdate>20100301</creationdate><title>The cognitive and neural expression of semantic memory impairment in mild cognitive impairment and early Alzheimer's disease</title><author>Joubert, Sven ; Brambati, Simona M. ; Ansado, Jennyfer ; Barbeau, Emmanuel J. ; Felician, Olivier ; Didic, Mira ; Lacombe, Jacinthe ; Goldstein, Rachel ; Chayer, Céline ; Kergoat, Marie-Jeanne</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c476t-7891cf95fc29bc0582832a0d58f6d1451cf1fa6e344b0e033e605f6551a889533</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Adult and adolescent clinical studies</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Alzheimer Disease - psychology</topic><topic>Alzheimer's disease</topic><topic>Alzheimers Disease</topic><topic>Anomia - psychology</topic><topic>Biological and medical sciences</topic><topic>Brain - pathology</topic><topic>Brain - physiopathology</topic><topic>Brain Hemisphere Functions</topic><topic>Cognition</topic><topic>Cognition Disorders - psychology</topic><topic>Comparative Analysis</topic><topic>Control Groups</topic><topic>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</topic><topic>Diseases</topic><topic>Female</topic><topic>Geriatrics</topic><topic>Humans</topic><topic>Integrity</topic><topic>Language Tests</topic><topic>Life Sciences</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Memory</topic><topic>Memory Disorders - psychology</topic><topic>Mental Retardation</topic><topic>Mild cognitive impairment</topic><topic>Naming</topic><topic>Neurological Impairments</topic><topic>Neurology</topic><topic>Neurons and Cognition</topic><topic>Neuropsychological Tests</topic><topic>Older Adults</topic><topic>Organic mental disorders. Neuropsychology</topic><topic>Prefrontal Cortex - pathology</topic><topic>Prefrontal Cortex - physiopathology</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychomotor Performance</topic><topic>Psychopathology. Psychiatry</topic><topic>Semantic memory</topic><topic>Semantics</topic><topic>Semiotics</topic><topic>Severity of Illness Index</topic><topic>Temporal Lobe - pathology</topic><topic>Temporal Lobe - physiopathology</topic><topic>Verbal Behavior</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Joubert, Sven</creatorcontrib><creatorcontrib>Brambati, Simona M.</creatorcontrib><creatorcontrib>Ansado, Jennyfer</creatorcontrib><creatorcontrib>Barbeau, Emmanuel J.</creatorcontrib><creatorcontrib>Felician, Olivier</creatorcontrib><creatorcontrib>Didic, Mira</creatorcontrib><creatorcontrib>Lacombe, Jacinthe</creatorcontrib><creatorcontrib>Goldstein, Rachel</creatorcontrib><creatorcontrib>Chayer, Céline</creatorcontrib><creatorcontrib>Kergoat, Marie-Jeanne</creatorcontrib><collection>ERIC</collection><collection>ERIC (Ovid)</collection><collection>ERIC</collection><collection>ERIC</collection><collection>ERIC (Legacy Platform)</collection><collection>ERIC( SilverPlatter )</collection><collection>ERIC</collection><collection>ERIC PlusText (Legacy Platform)</collection><collection>Education Resources Information Center (ERIC)</collection><collection>ERIC</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><jtitle>Neuropsychologia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Joubert, Sven</au><au>Brambati, Simona M.</au><au>Ansado, Jennyfer</au><au>Barbeau, Emmanuel J.</au><au>Felician, Olivier</au><au>Didic, Mira</au><au>Lacombe, Jacinthe</au><au>Goldstein, Rachel</au><au>Chayer, Céline</au><au>Kergoat, Marie-Jeanne</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><ericid>EJ877784</ericid><atitle>The cognitive and neural expression of semantic memory impairment in mild cognitive impairment and early Alzheimer's disease</atitle><jtitle>Neuropsychologia</jtitle><addtitle>Neuropsychologia</addtitle><date>2010-03-01</date><risdate>2010</risdate><volume>48</volume><issue>4</issue><spage>978</spage><epage>988</epage><pages>978-988</pages><issn>0028-3932</issn><eissn>1873-3514</eissn><coden>NUPSA6</coden><abstract>Semantic deficits in Alzheimer's disease have been widely documented, but little is known about the integrity of semantic memory in the prodromal stage of the illness. The aims of the present study were to: (i) investigate naming abilities and semantic memory in amnestic mild cognitive impairment (aMCI), early Alzheimer's disease (AD) compared to healthy older subjects; (ii) investigate the association between naming and semantic knowledge in aMCI and AD; (iii) examine if the semantic impairment was present in different modalities; and (iv) study the relationship between semantic performance and grey matter volume using voxel-based morphometry. Results indicate that both naming and semantic knowledge of objects and famous people were impaired in aMCI and early AD groups, when compared to healthy age- and education-matched controls. Item-by-item analyses showed that anomia in aMCI and early AD was significantly associated with underlying semantic knowledge of famous people but not with semantic knowledge of objects. Moreover, semantic knowledge of the same concepts was impaired in both the visual and the verbal modalities. Finally, voxel-based morphometry analyses revealed that semantic impairment in aMCI and AD was associated with cortical atrophy in the anterior temporal lobe (ATL) region as well as in the inferior prefrontal cortex (IPC), some of the key regions of the semantic cognition network. These findings suggest that the semantic impairment in aMCI may result from a breakdown of semantic knowledge of famous people and objects, combined with difficulties in the selection, manipulation and retrieval of this knowledge.</abstract><cop>Kidlington</cop><pub>Elsevier Ltd</pub><pmid>19954747</pmid><doi>10.1016/j.neuropsychologia.2009.11.019</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0003-0836-3538</orcidid><orcidid>https://orcid.org/0000-0001-7067-536X</orcidid></addata></record> |
| fulltext | fulltext |
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| ispartof | Neuropsychologia, 2010-03, Vol.48 (4), p.978-988 |
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| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Adult and adolescent clinical studies Aged Aged, 80 and over Alzheimer Disease - psychology Alzheimer's disease Alzheimers Disease Anomia - psychology Biological and medical sciences Brain - pathology Brain - physiopathology Brain Hemisphere Functions Cognition Cognition Disorders - psychology Comparative Analysis Control Groups Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Diseases Female Geriatrics Humans Integrity Language Tests Life Sciences Male Medical sciences Memory Memory Disorders - psychology Mental Retardation Mild cognitive impairment Naming Neurological Impairments Neurology Neurons and Cognition Neuropsychological Tests Older Adults Organic mental disorders. Neuropsychology Prefrontal Cortex - pathology Prefrontal Cortex - physiopathology Psychology. Psychoanalysis. Psychiatry Psychomotor Performance Psychopathology. Psychiatry Semantic memory Semantics Semiotics Severity of Illness Index Temporal Lobe - pathology Temporal Lobe - physiopathology Verbal Behavior |
| title | The cognitive and neural expression of semantic memory impairment in mild cognitive impairment and early Alzheimer's disease |
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