Preconditioning during coronary angioplasty: no influence of collateral perfusion or the size of the area at risk
Aims It is unclear whether the protection observed in human heart following repetition of brief episodes of ischaemia is due to opening of coronary collaterals or to ischaemic preconditioning. We investigated whether the improvement in ST segment change following repeated episodes of brief ischaemia...
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| Veröffentlicht in: | European heart journal 2004-11, Vol.25 (22), p.2019-2025 |
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| creator | Argaud, Laurent Rioufol, G. Lièvre, M. Bontemps, L. Legalery, P. Stumpf, M. Finet, G. Itti, R. André-Fouët, X. Ovize, M. |
| description | Aims It is unclear whether the protection observed in human heart following repetition of brief episodes of ischaemia is due to opening of coronary collaterals or to ischaemic preconditioning. We investigated whether the improvement in ST segment change following repeated episodes of brief ischaemia during coronary angioplasty is due to preconditioning when the size of the area at risk and the collateral flow are taken into account. Methods and results Thirty-six patients underwent percutaneous transluminal coronary angioplasty. Intracoronary ST segment changes were measured throughout the procedure and used as an endpoint. The size of the area at risk and the collateral perfusion within the ischaemic bed were measured using single photon emission computerized tomography (SPECT). Mean ST segment shift observed in all patients significantly decreased from 11.0±2.6 mm during the first balloon inflation to 8.5±2.3 mm during the second inflation. This protective effect occurred in the absence of any change in the size of the area at risk (mean: 46±5% of LV) and of the collateral perfusion to the ischaemic zone (mean: 23±4% of flow in the non-ischaemic zone). Conclusion These results suggest that ischaemic preconditioning does occur during repeated brief coronary artery occlusion in the human heart. |
| doi_str_mv | 10.1016/j.ehj.2004.07.040 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_hal_p</sourceid><recordid>TN_cdi_hal_primary_oai_HAL_hal_00427504v1</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>67069406</sourcerecordid><originalsourceid>FETCH-LOGICAL-c399t-64be2832fe0603e4f45d5132679e6c4845d0495046cc156ae2d44f472dde7d7a3</originalsourceid><addsrcrecordid>eNpFkUtv1DAURi0EokPhB7BB3oDEIsF2_IjZtRV0kEbAAmjVjeU6Nx1PM_bUThDl1-Mwo3Z1_Tj3yNcfQq8pqSmh8sOmhvWmZoTwmqiacPIELahgrNKSi6doQagWlZTt5RF6kfOGENJKKp-jIyoEp23TLtDd9wQuhs6PPgYfbnA3pbm4mGKw6R7bcOPjbrB5vP-IQ8Q-9MMEwQGOfaGGwY6Q7IB3kPopFwmOCY9rwNn__c_Ma5vAYjvi5PPtS_Sst0OGV4d6jH5-_vTjbFmtvp1_OTtZVa7ReqwkvwbWNqwHIkkDvOeiE7RhUmmQjrdlS7gWhEvnqJAWWMcLpFjXgeqUbY7R-713bQezS35bpjHRerM8WZn5rHwbU0Xwmxb23Z7dpXg3QR7N1mcHZbgAccpGKiI1J7KAdA-6FHNO0D-YKTFzJmZjSiZmzsQQZUompefNQT5db6F77DiEUIC3B8BmZ4c-2eB8fuQka3WrZ1G153we4c_DvU235YGNEmZ5eWVOr77-0vr8wlw0_wDCNaUR</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>67069406</pqid></control><display><type>article</type><title>Preconditioning during coronary angioplasty: no influence of collateral perfusion or the size of the area at risk</title><source>MEDLINE</source><source>Oxford University Press Journals All Titles (1996-Current)</source><source>EZB-FREE-00999 freely available EZB journals</source><creator>Argaud, Laurent ; Rioufol, G. ; Lièvre, M. ; Bontemps, L. ; Legalery, P. ; Stumpf, M. ; Finet, G. ; Itti, R. ; André-Fouët, X. ; Ovize, M.</creator><creatorcontrib>Argaud, Laurent ; Rioufol, G. ; Lièvre, M. ; Bontemps, L. ; Legalery, P. ; Stumpf, M. ; Finet, G. ; Itti, R. ; André-Fouët, X. ; Ovize, M.</creatorcontrib><description>Aims It is unclear whether the protection observed in human heart following repetition of brief episodes of ischaemia is due to opening of coronary collaterals or to ischaemic preconditioning. We investigated whether the improvement in ST segment change following repeated episodes of brief ischaemia during coronary angioplasty is due to preconditioning when the size of the area at risk and the collateral flow are taken into account. Methods and results Thirty-six patients underwent percutaneous transluminal coronary angioplasty. Intracoronary ST segment changes were measured throughout the procedure and used as an endpoint. The size of the area at risk and the collateral perfusion within the ischaemic bed were measured using single photon emission computerized tomography (SPECT). Mean ST segment shift observed in all patients significantly decreased from 11.0±2.6 mm during the first balloon inflation to 8.5±2.3 mm during the second inflation. This protective effect occurred in the absence of any change in the size of the area at risk (mean: 46±5% of LV) and of the collateral perfusion to the ischaemic zone (mean: 23±4% of flow in the non-ischaemic zone). Conclusion These results suggest that ischaemic preconditioning does occur during repeated brief coronary artery occlusion in the human heart.</description><identifier>ISSN: 0195-668X</identifier><identifier>EISSN: 1522-9645</identifier><identifier>DOI: 10.1016/j.ehj.2004.07.040</identifier><identifier>PMID: 15541838</identifier><language>eng</language><publisher>Oxford: Oxford University Press</publisher><subject>Adolescent ; Adult ; Aged ; Aged, 80 and over ; Angioplasty, Balloon, Coronary - methods ; Biological and medical sciences ; Cardiology. Vascular system ; Coronary heart disease ; Coronary Stenosis - therapy ; Diseases of the cardiovascular system ; Double-Blind Method ; Female ; Heart ; Humans ; Ischemic Preconditioning, Myocardial - methods ; Life Sciences ; Male ; Medical sciences ; Middle Aged ; Other ; Prospective Studies ; Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects) ; Risk Factors ; Tomography, Emission-Computed, Single-Photon</subject><ispartof>European heart journal, 2004-11, Vol.25 (22), p.2019-2025</ispartof><rights>2005 INIST-CNRS</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c399t-64be2832fe0603e4f45d5132679e6c4845d0495046cc156ae2d44f472dde7d7a3</citedby><orcidid>0000-0002-6318-1473 ; 0000-0002-2146-9874</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27923,27924</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16289890$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15541838$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.science/hal-00427504$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Argaud, Laurent</creatorcontrib><creatorcontrib>Rioufol, G.</creatorcontrib><creatorcontrib>Lièvre, M.</creatorcontrib><creatorcontrib>Bontemps, L.</creatorcontrib><creatorcontrib>Legalery, P.</creatorcontrib><creatorcontrib>Stumpf, M.</creatorcontrib><creatorcontrib>Finet, G.</creatorcontrib><creatorcontrib>Itti, R.</creatorcontrib><creatorcontrib>André-Fouët, X.</creatorcontrib><creatorcontrib>Ovize, M.</creatorcontrib><title>Preconditioning during coronary angioplasty: no influence of collateral perfusion or the size of the area at risk</title><title>European heart journal</title><addtitle>Eur Heart J</addtitle><description>Aims It is unclear whether the protection observed in human heart following repetition of brief episodes of ischaemia is due to opening of coronary collaterals or to ischaemic preconditioning. We investigated whether the improvement in ST segment change following repeated episodes of brief ischaemia during coronary angioplasty is due to preconditioning when the size of the area at risk and the collateral flow are taken into account. Methods and results Thirty-six patients underwent percutaneous transluminal coronary angioplasty. Intracoronary ST segment changes were measured throughout the procedure and used as an endpoint. The size of the area at risk and the collateral perfusion within the ischaemic bed were measured using single photon emission computerized tomography (SPECT). Mean ST segment shift observed in all patients significantly decreased from 11.0±2.6 mm during the first balloon inflation to 8.5±2.3 mm during the second inflation. This protective effect occurred in the absence of any change in the size of the area at risk (mean: 46±5% of LV) and of the collateral perfusion to the ischaemic zone (mean: 23±4% of flow in the non-ischaemic zone). Conclusion These results suggest that ischaemic preconditioning does occur during repeated brief coronary artery occlusion in the human heart.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Angioplasty, Balloon, Coronary - methods</subject><subject>Biological and medical sciences</subject><subject>Cardiology. Vascular system</subject><subject>Coronary heart disease</subject><subject>Coronary Stenosis - therapy</subject><subject>Diseases of the cardiovascular system</subject><subject>Double-Blind Method</subject><subject>Female</subject><subject>Heart</subject><subject>Humans</subject><subject>Ischemic Preconditioning, Myocardial - methods</subject><subject>Life Sciences</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Other</subject><subject>Prospective Studies</subject><subject>Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)</subject><subject>Risk Factors</subject><subject>Tomography, Emission-Computed, Single-Photon</subject><issn>0195-668X</issn><issn>1522-9645</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkUtv1DAURi0EokPhB7BB3oDEIsF2_IjZtRV0kEbAAmjVjeU6Nx1PM_bUThDl1-Mwo3Z1_Tj3yNcfQq8pqSmh8sOmhvWmZoTwmqiacPIELahgrNKSi6doQagWlZTt5RF6kfOGENJKKp-jIyoEp23TLtDd9wQuhs6PPgYfbnA3pbm4mGKw6R7bcOPjbrB5vP-IQ8Q-9MMEwQGOfaGGwY6Q7IB3kPopFwmOCY9rwNn__c_Ma5vAYjvi5PPtS_Sst0OGV4d6jH5-_vTjbFmtvp1_OTtZVa7ReqwkvwbWNqwHIkkDvOeiE7RhUmmQjrdlS7gWhEvnqJAWWMcLpFjXgeqUbY7R-713bQezS35bpjHRerM8WZn5rHwbU0Xwmxb23Z7dpXg3QR7N1mcHZbgAccpGKiI1J7KAdA-6FHNO0D-YKTFzJmZjSiZmzsQQZUompefNQT5db6F77DiEUIC3B8BmZ4c-2eB8fuQka3WrZ1G153we4c_DvU235YGNEmZ5eWVOr77-0vr8wlw0_wDCNaUR</recordid><startdate>20041101</startdate><enddate>20041101</enddate><creator>Argaud, Laurent</creator><creator>Rioufol, G.</creator><creator>Lièvre, M.</creator><creator>Bontemps, L.</creator><creator>Legalery, P.</creator><creator>Stumpf, M.</creator><creator>Finet, G.</creator><creator>Itti, R.</creator><creator>André-Fouët, X.</creator><creator>Ovize, M.</creator><general>Oxford University Press</general><general>Oxford University Press (OUP)</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>1XC</scope><orcidid>https://orcid.org/0000-0002-6318-1473</orcidid><orcidid>https://orcid.org/0000-0002-2146-9874</orcidid></search><sort><creationdate>20041101</creationdate><title>Preconditioning during coronary angioplasty: no influence of collateral perfusion or the size of the area at risk</title><author>Argaud, Laurent ; Rioufol, G. ; Lièvre, M. ; Bontemps, L. ; Legalery, P. ; Stumpf, M. ; Finet, G. ; Itti, R. ; André-Fouët, X. ; Ovize, M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c399t-64be2832fe0603e4f45d5132679e6c4845d0495046cc156ae2d44f472dde7d7a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Angioplasty, Balloon, Coronary - methods</topic><topic>Biological and medical sciences</topic><topic>Cardiology. Vascular system</topic><topic>Coronary heart disease</topic><topic>Coronary Stenosis - therapy</topic><topic>Diseases of the cardiovascular system</topic><topic>Double-Blind Method</topic><topic>Female</topic><topic>Heart</topic><topic>Humans</topic><topic>Ischemic Preconditioning, Myocardial - methods</topic><topic>Life Sciences</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Other</topic><topic>Prospective Studies</topic><topic>Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)</topic><topic>Risk Factors</topic><topic>Tomography, Emission-Computed, Single-Photon</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Argaud, Laurent</creatorcontrib><creatorcontrib>Rioufol, G.</creatorcontrib><creatorcontrib>Lièvre, M.</creatorcontrib><creatorcontrib>Bontemps, L.</creatorcontrib><creatorcontrib>Legalery, P.</creatorcontrib><creatorcontrib>Stumpf, M.</creatorcontrib><creatorcontrib>Finet, G.</creatorcontrib><creatorcontrib>Itti, R.</creatorcontrib><creatorcontrib>André-Fouët, X.</creatorcontrib><creatorcontrib>Ovize, M.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><jtitle>European heart journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Argaud, Laurent</au><au>Rioufol, G.</au><au>Lièvre, M.</au><au>Bontemps, L.</au><au>Legalery, P.</au><au>Stumpf, M.</au><au>Finet, G.</au><au>Itti, R.</au><au>André-Fouët, X.</au><au>Ovize, M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Preconditioning during coronary angioplasty: no influence of collateral perfusion or the size of the area at risk</atitle><jtitle>European heart journal</jtitle><addtitle>Eur Heart J</addtitle><date>2004-11-01</date><risdate>2004</risdate><volume>25</volume><issue>22</issue><spage>2019</spage><epage>2025</epage><pages>2019-2025</pages><issn>0195-668X</issn><eissn>1522-9645</eissn><abstract>Aims It is unclear whether the protection observed in human heart following repetition of brief episodes of ischaemia is due to opening of coronary collaterals or to ischaemic preconditioning. We investigated whether the improvement in ST segment change following repeated episodes of brief ischaemia during coronary angioplasty is due to preconditioning when the size of the area at risk and the collateral flow are taken into account. Methods and results Thirty-six patients underwent percutaneous transluminal coronary angioplasty. Intracoronary ST segment changes were measured throughout the procedure and used as an endpoint. The size of the area at risk and the collateral perfusion within the ischaemic bed were measured using single photon emission computerized tomography (SPECT). Mean ST segment shift observed in all patients significantly decreased from 11.0±2.6 mm during the first balloon inflation to 8.5±2.3 mm during the second inflation. This protective effect occurred in the absence of any change in the size of the area at risk (mean: 46±5% of LV) and of the collateral perfusion to the ischaemic zone (mean: 23±4% of flow in the non-ischaemic zone). Conclusion These results suggest that ischaemic preconditioning does occur during repeated brief coronary artery occlusion in the human heart.</abstract><cop>Oxford</cop><pub>Oxford University Press</pub><pmid>15541838</pmid><doi>10.1016/j.ehj.2004.07.040</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-6318-1473</orcidid><orcidid>https://orcid.org/0000-0002-2146-9874</orcidid></addata></record> |
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| ispartof | European heart journal, 2004-11, Vol.25 (22), p.2019-2025 |
| issn | 0195-668X 1522-9645 |
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| source | MEDLINE; Oxford University Press Journals All Titles (1996-Current); EZB-FREE-00999 freely available EZB journals |
| subjects | Adolescent Adult Aged Aged, 80 and over Angioplasty, Balloon, Coronary - methods Biological and medical sciences Cardiology. Vascular system Coronary heart disease Coronary Stenosis - therapy Diseases of the cardiovascular system Double-Blind Method Female Heart Humans Ischemic Preconditioning, Myocardial - methods Life Sciences Male Medical sciences Middle Aged Other Prospective Studies Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects) Risk Factors Tomography, Emission-Computed, Single-Photon |
| title | Preconditioning during coronary angioplasty: no influence of collateral perfusion or the size of the area at risk |
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