In vivo degradation of massive poly(α-hydroxy acids): Validation of In vitro findings
The degradation of various high-molecular-weight aliphatic polyesters derived from glycolic acid and/or lactic acid enantiomers was previously investigated in vitro. It was demonstrated that the bulk degradation mechanism proposed in the literature actually proceeds heterogeneously and proceeds fast...
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| Veröffentlicht in: | Biomaterials 1992, Vol.13 (9), p.594-600 |
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| creator | Therin, Michel Christel, Pascal Li, Suming Garreau, Henri Vert, Michel |
| description | The degradation of various high-molecular-weight aliphatic polyesters derived from glycolic acid and/or lactic acid enantiomers was previously investigated
in vitro. It was demonstrated that the bulk degradation mechanism proposed in the literature actually proceeds heterogeneously and proceeds faster in the centre than at the surface of large specimens. In order to compare them, similar compression-moulded specimens were implanted intramuscularly in the backs of rabbits, namely PLA50 (poly(DL-lactic acid)), PLA37.5GA25 (75% DL-lactide and 25% glycolide in the feed) and PLA75GA25 (75%
l-lactide and 25% glycolide). These three intrinsically amorphous compounds exhibited faster central degradation. Furthermore, preferential degradation of glycolic acid units and induced crystallization of
l-lactic acid enriched fragments were observed in the case of PLA75GA25. These findings are comparable to phenomena observed
in vitro and are conclusively supported by the re-examination of some old
in vivo results. Accordingly, data reported in this paper validate both the
in vitro modelling and new understanding of the degradation of lactic acid/glycolic acid-based aliphatic polyesters reported previously. |
| doi_str_mv | 10.1016/0142-9612(92)90027-L |
| format | Article |
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in vitro. It was demonstrated that the bulk degradation mechanism proposed in the literature actually proceeds heterogeneously and proceeds faster in the centre than at the surface of large specimens. In order to compare them, similar compression-moulded specimens were implanted intramuscularly in the backs of rabbits, namely PLA50 (poly(DL-lactic acid)), PLA37.5GA25 (75% DL-lactide and 25% glycolide in the feed) and PLA75GA25 (75%
l-lactide and 25% glycolide). These three intrinsically amorphous compounds exhibited faster central degradation. Furthermore, preferential degradation of glycolic acid units and induced crystallization of
l-lactic acid enriched fragments were observed in the case of PLA75GA25. These findings are comparable to phenomena observed
in vitro and are conclusively supported by the re-examination of some old
in vivo results. Accordingly, data reported in this paper validate both the
in vitro modelling and new understanding of the degradation of lactic acid/glycolic acid-based aliphatic polyesters reported previously.</description><identifier>ISSN: 0142-9612</identifier><identifier>EISSN: 1878-5905</identifier><identifier>DOI: 10.1016/0142-9612(92)90027-L</identifier><identifier>PMID: 1391406</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Ageing, cell death ; Animals ; Biocompatible Materials - metabolism ; Biodegradation ; Biological and medical sciences ; Cell physiology ; Chemical Sciences ; Fundamental and applied biological sciences. Psychology ; Lactates - metabolism ; Lactic Acid ; Materials Testing ; Molecular and cellular biology ; Molecular Weight ; poly(glycolic acid) ; poly(lactic acid) ; Polyesters - metabolism ; Polymers ; Polymers - metabolism ; Rabbits ; Stereoisomerism</subject><ispartof>Biomaterials, 1992, Vol.13 (9), p.594-600</ispartof><rights>1992</rights><rights>1992 INIST-CNRS</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c430t-279130a91c8abe78d85c2f8375b2b8896454f5590d1ba9045ecd88c3699300873</citedby><cites>FETCH-LOGICAL-c430t-279130a91c8abe78d85c2f8375b2b8896454f5590d1ba9045ecd88c3699300873</cites><orcidid>0000-0002-3345-1479 ; 0000-0002-5751-2520</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0142-9612(92)90027-L$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,777,781,882,3537,4010,27904,27905,27906,45976</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=5494762$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1391406$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.science/hal-00417744$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Therin, Michel</creatorcontrib><creatorcontrib>Christel, Pascal</creatorcontrib><creatorcontrib>Li, Suming</creatorcontrib><creatorcontrib>Garreau, Henri</creatorcontrib><creatorcontrib>Vert, Michel</creatorcontrib><title>In vivo degradation of massive poly(α-hydroxy acids): Validation of In vitro findings</title><title>Biomaterials</title><addtitle>Biomaterials</addtitle><description>The degradation of various high-molecular-weight aliphatic polyesters derived from glycolic acid and/or lactic acid enantiomers was previously investigated
in vitro. It was demonstrated that the bulk degradation mechanism proposed in the literature actually proceeds heterogeneously and proceeds faster in the centre than at the surface of large specimens. In order to compare them, similar compression-moulded specimens were implanted intramuscularly in the backs of rabbits, namely PLA50 (poly(DL-lactic acid)), PLA37.5GA25 (75% DL-lactide and 25% glycolide in the feed) and PLA75GA25 (75%
l-lactide and 25% glycolide). These three intrinsically amorphous compounds exhibited faster central degradation. Furthermore, preferential degradation of glycolic acid units and induced crystallization of
l-lactic acid enriched fragments were observed in the case of PLA75GA25. These findings are comparable to phenomena observed
in vitro and are conclusively supported by the re-examination of some old
in vivo results. Accordingly, data reported in this paper validate both the
in vitro modelling and new understanding of the degradation of lactic acid/glycolic acid-based aliphatic polyesters reported previously.</description><subject>Ageing, cell death</subject><subject>Animals</subject><subject>Biocompatible Materials - metabolism</subject><subject>Biodegradation</subject><subject>Biological and medical sciences</subject><subject>Cell physiology</subject><subject>Chemical Sciences</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Lactates - metabolism</subject><subject>Lactic Acid</subject><subject>Materials Testing</subject><subject>Molecular and cellular biology</subject><subject>Molecular Weight</subject><subject>poly(glycolic acid)</subject><subject>poly(lactic acid)</subject><subject>Polyesters - metabolism</subject><subject>Polymers</subject><subject>Polymers - metabolism</subject><subject>Rabbits</subject><subject>Stereoisomerism</subject><issn>0142-9612</issn><issn>1878-5905</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMFO3DAQhq2qiG4pb9BKOVSIPYSOHSe2OSAh1AJSJC7A1XJsB4yy8WJno-5j9UX6THWa1XJDsmSP55tf9ofQVwxnGHD1AzAluagwORVkKQAIy-sPaIE543kpoPyIFnvkE_oc4wukGig5RIe4EOlYLdDjbZ-NbvSZsU9BGTU432e-zVYqRjfabO277enfP_nz1gT_e5sp7UxcnmePqnNv9P-QIfisdb1x_VP8gg5a1UV7vNuP0MOvn_dXN3l9d317dVnnmhYw5IQJXIASWHPVWMYNLzVpecHKhjSci4qWtC3TZwxulABaWm0410UlRAHAWXGElnPus-rkOriVClvplZM3l7Wc7gAoZozSESf2ZGbXwb9ubBzkykVtu0711m-iZAUhBMQUSmdQBx9jsO0-GYOc1MvJq5y8SpHWpF7WaezbLn_TrKx5G5pdp_73XV9Frbo2qF67uMdKKiirSMIuZswmb6OzQUbtbK-tccHqQRrv3n_HP3pinbg</recordid><startdate>1992</startdate><enddate>1992</enddate><creator>Therin, Michel</creator><creator>Christel, Pascal</creator><creator>Li, Suming</creator><creator>Garreau, Henri</creator><creator>Vert, Michel</creator><general>Elsevier Ltd</general><general>Elsevier Science</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>1XC</scope><orcidid>https://orcid.org/0000-0002-3345-1479</orcidid><orcidid>https://orcid.org/0000-0002-5751-2520</orcidid></search><sort><creationdate>1992</creationdate><title>In vivo degradation of massive poly(α-hydroxy acids): Validation of In vitro findings</title><author>Therin, Michel ; Christel, Pascal ; Li, Suming ; Garreau, Henri ; Vert, Michel</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c430t-279130a91c8abe78d85c2f8375b2b8896454f5590d1ba9045ecd88c3699300873</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>Ageing, cell death</topic><topic>Animals</topic><topic>Biocompatible Materials - metabolism</topic><topic>Biodegradation</topic><topic>Biological and medical sciences</topic><topic>Cell physiology</topic><topic>Chemical Sciences</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Lactates - metabolism</topic><topic>Lactic Acid</topic><topic>Materials Testing</topic><topic>Molecular and cellular biology</topic><topic>Molecular Weight</topic><topic>poly(glycolic acid)</topic><topic>poly(lactic acid)</topic><topic>Polyesters - metabolism</topic><topic>Polymers</topic><topic>Polymers - metabolism</topic><topic>Rabbits</topic><topic>Stereoisomerism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Therin, Michel</creatorcontrib><creatorcontrib>Christel, Pascal</creatorcontrib><creatorcontrib>Li, Suming</creatorcontrib><creatorcontrib>Garreau, Henri</creatorcontrib><creatorcontrib>Vert, Michel</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><jtitle>Biomaterials</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Therin, Michel</au><au>Christel, Pascal</au><au>Li, Suming</au><au>Garreau, Henri</au><au>Vert, Michel</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>In vivo degradation of massive poly(α-hydroxy acids): Validation of In vitro findings</atitle><jtitle>Biomaterials</jtitle><addtitle>Biomaterials</addtitle><date>1992</date><risdate>1992</risdate><volume>13</volume><issue>9</issue><spage>594</spage><epage>600</epage><pages>594-600</pages><issn>0142-9612</issn><eissn>1878-5905</eissn><abstract>The degradation of various high-molecular-weight aliphatic polyesters derived from glycolic acid and/or lactic acid enantiomers was previously investigated
in vitro. It was demonstrated that the bulk degradation mechanism proposed in the literature actually proceeds heterogeneously and proceeds faster in the centre than at the surface of large specimens. In order to compare them, similar compression-moulded specimens were implanted intramuscularly in the backs of rabbits, namely PLA50 (poly(DL-lactic acid)), PLA37.5GA25 (75% DL-lactide and 25% glycolide in the feed) and PLA75GA25 (75%
l-lactide and 25% glycolide). These three intrinsically amorphous compounds exhibited faster central degradation. Furthermore, preferential degradation of glycolic acid units and induced crystallization of
l-lactic acid enriched fragments were observed in the case of PLA75GA25. These findings are comparable to phenomena observed
in vitro and are conclusively supported by the re-examination of some old
in vivo results. Accordingly, data reported in this paper validate both the
in vitro modelling and new understanding of the degradation of lactic acid/glycolic acid-based aliphatic polyesters reported previously.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>1391406</pmid><doi>10.1016/0142-9612(92)90027-L</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-3345-1479</orcidid><orcidid>https://orcid.org/0000-0002-5751-2520</orcidid></addata></record> |
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| ispartof | Biomaterials, 1992, Vol.13 (9), p.594-600 |
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| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Ageing, cell death Animals Biocompatible Materials - metabolism Biodegradation Biological and medical sciences Cell physiology Chemical Sciences Fundamental and applied biological sciences. Psychology Lactates - metabolism Lactic Acid Materials Testing Molecular and cellular biology Molecular Weight poly(glycolic acid) poly(lactic acid) Polyesters - metabolism Polymers Polymers - metabolism Rabbits Stereoisomerism |
| title | In vivo degradation of massive poly(α-hydroxy acids): Validation of In vitro findings |
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