Novel Biodegradable Polylactide/poly(ethylene glycol) Micelles Prepared by Direct Dissolution Method for Controlled Delivery of Anticancer Drugs

Purpose The aim of this study is to develop novel polylactide/poly(ethylene glycol) (PLA/PEG) micelles as carrier of hydrophobic drug (paclitaxel) by direct dissolution method without using any organic solvents. The in vitro and in vivo release properties were studied in comparison with micelles pre...

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Veröffentlicht in:	Pharmaceutical research 2009-10, Vol.26 (10), p.2332-2342
Hauptverfasser:	Yang, Liu, Wu, Xiaohan, Liu, Feng, Duan, Yourong, Li, Suming
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic agents Antineoplastic Agents, Phytogenic - administration & dosage Antineoplastic Agents, Phytogenic - chemistry Antineoplastic Agents, Phytogenic - pharmacokinetics Biochemistry Biocompatible Materials - chemical synthesis Biodegradable materials Biological and medical sciences Biomedical and Life Sciences Biomedical Engineering and Bioengineering Biomedicine Carcinoma, Lewis Lung - drug therapy Carcinoma, Lewis Lung - metabolism Chemical Sciences Chemotherapy Drug Delivery Systems - methods Female General pharmacology Humans Lung cancer Medical Law Medical sciences Mice Mice, Inbred C57BL Micelles Pharmaceutical technology. Pharmaceutical industry Pharmacology Pharmacology. Drug treatments Pharmacology/Toxicology Pharmacy Polyesters - administration & dosage Polyesters - chemistry Polyesters - pharmacokinetics Polyethylene Glycols - administration & dosage Polyethylene Glycols - pharmacokinetics Polymers Research Paper Rodents Xenograft Model Antitumor Assays - methods
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