A Prenylation Inhibitor (Sodium Phenylacetate) Differently Affects MCF-7 Cell Death when ras is Overexpressed, Partly Involving P42/44, JNK and P38 Kinase Activations

Background: Sodium phenylacetate (NaPa) inhibits breast cancer cell proliferation decreasing prenylation of small G proteins including Ras. Materials and Methods: Aponecrosis induced by NaPa in MCF-7 and MCF-7ras breast cancer cells was evaluated by measuring Annexin V/PI labelling by flow cytometry...

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Veröffentlicht in:	Anticancer research 2008-03, Vol.28 (2A), p.1029-1037
Hauptverfasser:	DI BENEDETTO, Mélanie, CREPIN, Michel, KRAEMER, Michel, OUDAR, Olivier
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis - drug effects Biological and medical sciences Cell Line, Tumor Flavonoids - pharmacology Genes, ras JNK Mitogen-Activated Protein Kinases - metabolism Medical sciences Mice Mitogen-Activated Protein Kinase 1 - metabolism Mitogen-Activated Protein Kinase 3 - metabolism p38 Mitogen-Activated Protein Kinases - metabolism Phenylacetates - pharmacology Proto-Oncogene Proteins p21(ras) - metabolism Tumors
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