A putative physiological role of hypothalamic CNTF in the control of energy homeostasis

Administration of CNTF durably reduces food intake and body weight in obese humans and rodent models. However, the involvement of endogenous CNTF in the central regulation of energy homeostasis needs to be elucidated. Here, we demonstrate that CNTF and its receptor are expressed in the arcuate nucle...

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Veröffentlicht in:	FEBS letters 2008-11, Vol.582 (27), p.3832-3838
Hauptverfasser:	Vacher, C.-M., Crépin, D., Aubourg, A., Couvreur, O., Bailleux, V., Nicolas, V., Férézou, J., Gripois, D., Gertler, A., Taouis, M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Appetite Regulation - drug effects Appetite Regulation - genetics Arcuate nucleus Arcuate Nucleus of Hypothalamus - metabolism Ciliary Neurotrophic Factor - administration & dosage Ciliary Neurotrophic Factor - genetics Ciliary Neurotrophic Factor - physiology Ciliary Neurotrophic Factor Receptor alpha Subunit - genetics Ciliary Neurotrophic Factor Receptor alpha Subunit - physiology CNTF Cognitive science Energy Metabolism - drug effects Energy Metabolism - genetics Female Food intake Gene Expression Genetic Predisposition to Disease Homeostasis Male Mitogen-Activated Protein Kinase Kinases - metabolism Neuroscience Obesity Obesity - genetics Obesity - prevention & control Phosphorylation Rats Rats, Wistar Recombinant Proteins - biosynthesis Unbalanced diet Weight Gain - drug effects Weight Gain - genetics
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