Metabotropic glutamate receptor subtype 4 selectively modulates both glutamate and GABA transmission in the striatum: implications for Parkinson’s disease treatment

Alterations of striatal synaptic transmission have been associated with several motor disorders involving the basal ganglia, such as Parkinson’s disease. For this reason, we investigated the role of group‐III metabotropic glutamate (mGlu) receptors in regulating synaptic transmission in the striatum...

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Veröffentlicht in:	Journal of neurochemistry 2009-05, Vol.109 (4), p.1096-1105
Hauptverfasser:	Cuomo, Dario, Martella, Giuseppina, Barabino, Emanuela, Platania, Paola, Vita, Daniela, Madeo, Graziella, Selvam, Chelliah, Goudet, Cyril, Oueslati, Nadia, Pin, Jean‐Philippe, Acher, Francine, Pisani, Antonio, Beurrier, Corinne, Melon, Christophe, Kerkerian‐Le Goff, Lydia, Gubellini, Paolo
Format:	Artikel
Sprache:	eng
Schlagworte:	akinesia Aminobutyrates - pharmacology Animals Antiparkinson Agents - therapeutic use basal ganglia Biological and medical sciences Cellular Biology Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Dose-Response Relationship, Drug Drugs Electrophysiology Excitatory Amino Acid Agonists - pharmacology Excitatory Postsynaptic Potentials - drug effects GABA Agonists - pharmacology gamma-Aminobutyric Acid - physiology glutamate Glutamic Acid - physiology Life Sciences Male Medical sciences metabotropic glutamate receptor Movement - drug effects Neostriatum - physiology Nervous system (semeiology, syndromes) Nervous system as a whole Neurological disorders Neurology Oxidopamine Parkinson Disease, Secondary - chemically induced Parkinson Disease, Secondary - drug therapy Parkinson Disease, Secondary - physiopathology Patch-Clamp Techniques Pharmacology Rats Rats, Wistar Receptors, Metabotropic Glutamate - drug effects Receptors, Metabotropic Glutamate - physiology Rodents Sympatholytics Synaptic Transmission - drug effects Tetrodotoxin - pharmacology γ‐aminobutyric acid
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