Interleukin-22-producing innate immune cells: new players in mucosal immunity and tissue repair?
Recent studies have identified a new population of interleukin-22-producing cells in mucosal tissues that share features with both lymphoid-tissue inducer cells and natural killer cells. How are these three cell populations related and what might be the function of the new cell population? Mucosal t...
Gespeichert in:
| Veröffentlicht in: | Nature reviews. Immunology 2009-04, Vol.9 (4), p.229-234 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 234 |
|---|---|
| container_issue | 4 |
| container_start_page | 229 |
| container_title | Nature reviews. Immunology |
| container_volume | 9 |
| creator | Vivier, Eric Cupedo, Tom Spits, Hergen |
| description | Recent studies have identified a new population of interleukin-22-producing cells in mucosal tissues that share features with both lymphoid-tissue inducer cells and natural killer cells. How are these three cell populations related and what might be the function of the new cell population?
Mucosal tissues, lying at the interface with the external environment, are constantly challenged by microbial, physical and chemical assaults. To provide the necessary immune defence to such challenges, lymph nodes and Peyer's patches are formed
in utero
in response to inductive signals from lymphoid-tissue inducer (LTi) cells. As discussed in this Progress article, a series of recent reports has identified a population of interleukin-22-producing mucosal cells in the gut and tonsils that share features with both LTi cells (by expressing RORγt) and natural killer cells (by expressing NKp46) and that might be involved in immunity and homeostasis in mucosal tissues. |
| doi_str_mv | 10.1038/nri2522 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_hal_p</sourceid><recordid>TN_cdi_hal_primary_oai_HAL_hal_00408427v1</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A196964470</galeid><sourcerecordid>A196964470</sourcerecordid><originalsourceid>FETCH-LOGICAL-c558t-11bf41c72bc01a8d4a843f6ee40413816631a65a98bda5cdd0a1722ae9f5defd3</originalsourceid><addsrcrecordid>eNqF0t2L1DAQAPAiinee4l-gFIXTe-iZSdO09UWWQ72FBcGP5zjbTvdytumaD3X_e7N03XNVkDwkzPwyMMMkyUNg58Dy6oWxmhec30qOQZQig1LA7f07z4-Se85dMwYyZu4mR1DnUIOA4-Tz3HiyPYUv2mScZ2s7tqHRZpVqY9BTqochGEob6nv3MjX0PV33uCHrIkiH0IwO-wlpv0nRtKnXzgVKLa1R21f3kzsd9o4e7O6T5NOb1x8vLrPFu7fzi9kia4qi8hnAshPQlHzZMMCqFViJvJNEggnIK5AyB5QF1tWyxaJpW4ZQco5Ud0VLXZufJGdT3Svs1drqAe1GjajV5WyhtjHGBKsEL79BtKeTjd1-DeS8GrTbdoiGxuCULFnJJOP_hZyJqhK1jPDJH_B6DNbEhhXnAiRneR3R0wmtsCelTTd6i822oppBLWspRMmiOv-HiqelQTejoU7H-MGHs4MP0Xj64VcYnFPzD-8P7elv9oqw91du7IPXo3GH8NkEGzs6Z6nbzxSY2q6c2q1clI93rYflQO2N2-1YBM8n4GLKrMjezObvWo8mGlcvWNrX-pX_Caos5Lc</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>224162039</pqid></control><display><type>article</type><title>Interleukin-22-producing innate immune cells: new players in mucosal immunity and tissue repair?</title><source>MEDLINE</source><source>Nature</source><source>Alma/SFX Local Collection</source><creator>Vivier, Eric ; Cupedo, Tom ; Spits, Hergen</creator><creatorcontrib>Vivier, Eric ; Cupedo, Tom ; Spits, Hergen</creatorcontrib><description>Recent studies have identified a new population of interleukin-22-producing cells in mucosal tissues that share features with both lymphoid-tissue inducer cells and natural killer cells. How are these three cell populations related and what might be the function of the new cell population?
Mucosal tissues, lying at the interface with the external environment, are constantly challenged by microbial, physical and chemical assaults. To provide the necessary immune defence to such challenges, lymph nodes and Peyer's patches are formed
in utero
in response to inductive signals from lymphoid-tissue inducer (LTi) cells. As discussed in this Progress article, a series of recent reports has identified a population of interleukin-22-producing mucosal cells in the gut and tonsils that share features with both LTi cells (by expressing RORγt) and natural killer cells (by expressing NKp46) and that might be involved in immunity and homeostasis in mucosal tissues.</description><identifier>ISSN: 1474-1733</identifier><identifier>ISSN: 1474-1741</identifier><identifier>EISSN: 1474-1741</identifier><identifier>DOI: 10.1038/nri2522</identifier><identifier>PMID: 19319141</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Animals ; Biomedical and Life Sciences ; Biomedicine ; Cell Lineage ; Chemokines ; Cytokines ; Embryos ; Genetic aspects ; Health aspects ; Humans ; Immunity ; Immunity, Innate ; Immunity, Innate - immunology ; Immunity, Mucosal ; Immunity, Mucosal - immunology ; Immunology ; Interleukin-22 ; Interleukins ; Interleukins - biosynthesis ; Intestinal Mucosa ; Intestinal Mucosa - cytology ; Intestinal Mucosa - physiology ; Killer cells ; Killer Cells, Natural ; Killer Cells, Natural - cytology ; Killer Cells, Natural - physiology ; Life Sciences ; Lymph nodes ; Lymphatic system ; Lymphocytes ; Lymphocytes - cytology ; Lymphocytes - immunology ; Lymphocytes - metabolism ; Lymphocytes - physiology ; Lymphoid Progenitor Cells ; Lymphoid Progenitor Cells - cytology ; Lymphoid Progenitor Cells - physiology ; Lymphoid tissue ; Mice ; Models, Biological ; Palatine Tonsil ; Palatine Tonsil - cytology ; Palatine Tonsil - physiology ; Physiological aspects ; progress ; Proteins ; Regeneration ; Regeneration - physiology ; Tissues ; Tumor necrosis factor-TNF</subject><ispartof>Nature reviews. Immunology, 2009-04, Vol.9 (4), p.229-234</ispartof><rights>Springer Nature Limited 2009</rights><rights>COPYRIGHT 2009 Nature Publishing Group</rights><rights>Copyright Nature Publishing Group Apr 2009</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c558t-11bf41c72bc01a8d4a843f6ee40413816631a65a98bda5cdd0a1722ae9f5defd3</citedby><cites>FETCH-LOGICAL-c558t-11bf41c72bc01a8d4a843f6ee40413816631a65a98bda5cdd0a1722ae9f5defd3</cites><orcidid>0000-0001-7022-8287</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,2727,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19319141$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.science/hal-00408427$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Vivier, Eric</creatorcontrib><creatorcontrib>Cupedo, Tom</creatorcontrib><creatorcontrib>Spits, Hergen</creatorcontrib><title>Interleukin-22-producing innate immune cells: new players in mucosal immunity and tissue repair?</title><title>Nature reviews. Immunology</title><addtitle>Nat Rev Immunol</addtitle><addtitle>Nat Rev Immunol</addtitle><description>Recent studies have identified a new population of interleukin-22-producing cells in mucosal tissues that share features with both lymphoid-tissue inducer cells and natural killer cells. How are these three cell populations related and what might be the function of the new cell population?
Mucosal tissues, lying at the interface with the external environment, are constantly challenged by microbial, physical and chemical assaults. To provide the necessary immune defence to such challenges, lymph nodes and Peyer's patches are formed
in utero
in response to inductive signals from lymphoid-tissue inducer (LTi) cells. As discussed in this Progress article, a series of recent reports has identified a population of interleukin-22-producing mucosal cells in the gut and tonsils that share features with both LTi cells (by expressing RORγt) and natural killer cells (by expressing NKp46) and that might be involved in immunity and homeostasis in mucosal tissues.</description><subject>Animals</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cell Lineage</subject><subject>Chemokines</subject><subject>Cytokines</subject><subject>Embryos</subject><subject>Genetic aspects</subject><subject>Health aspects</subject><subject>Humans</subject><subject>Immunity</subject><subject>Immunity, Innate</subject><subject>Immunity, Innate - immunology</subject><subject>Immunity, Mucosal</subject><subject>Immunity, Mucosal - immunology</subject><subject>Immunology</subject><subject>Interleukin-22</subject><subject>Interleukins</subject><subject>Interleukins - biosynthesis</subject><subject>Intestinal Mucosa</subject><subject>Intestinal Mucosa - cytology</subject><subject>Intestinal Mucosa - physiology</subject><subject>Killer cells</subject><subject>Killer Cells, Natural</subject><subject>Killer Cells, Natural - cytology</subject><subject>Killer Cells, Natural - physiology</subject><subject>Life Sciences</subject><subject>Lymph nodes</subject><subject>Lymphatic system</subject><subject>Lymphocytes</subject><subject>Lymphocytes - cytology</subject><subject>Lymphocytes - immunology</subject><subject>Lymphocytes - metabolism</subject><subject>Lymphocytes - physiology</subject><subject>Lymphoid Progenitor Cells</subject><subject>Lymphoid Progenitor Cells - cytology</subject><subject>Lymphoid Progenitor Cells - physiology</subject><subject>Lymphoid tissue</subject><subject>Mice</subject><subject>Models, Biological</subject><subject>Palatine Tonsil</subject><subject>Palatine Tonsil - cytology</subject><subject>Palatine Tonsil - physiology</subject><subject>Physiological aspects</subject><subject>progress</subject><subject>Proteins</subject><subject>Regeneration</subject><subject>Regeneration - physiology</subject><subject>Tissues</subject><subject>Tumor necrosis factor-TNF</subject><issn>1474-1733</issn><issn>1474-1741</issn><issn>1474-1741</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqF0t2L1DAQAPAiinee4l-gFIXTe-iZSdO09UWWQ72FBcGP5zjbTvdytumaD3X_e7N03XNVkDwkzPwyMMMkyUNg58Dy6oWxmhec30qOQZQig1LA7f07z4-Se85dMwYyZu4mR1DnUIOA4-Tz3HiyPYUv2mScZ2s7tqHRZpVqY9BTqochGEob6nv3MjX0PV33uCHrIkiH0IwO-wlpv0nRtKnXzgVKLa1R21f3kzsd9o4e7O6T5NOb1x8vLrPFu7fzi9kia4qi8hnAshPQlHzZMMCqFViJvJNEggnIK5AyB5QF1tWyxaJpW4ZQco5Ud0VLXZufJGdT3Svs1drqAe1GjajV5WyhtjHGBKsEL79BtKeTjd1-DeS8GrTbdoiGxuCULFnJJOP_hZyJqhK1jPDJH_B6DNbEhhXnAiRneR3R0wmtsCelTTd6i822oppBLWspRMmiOv-HiqelQTejoU7H-MGHs4MP0Xj64VcYnFPzD-8P7elv9oqw91du7IPXo3GH8NkEGzs6Z6nbzxSY2q6c2q1clI93rYflQO2N2-1YBM8n4GLKrMjezObvWo8mGlcvWNrX-pX_Caos5Lc</recordid><startdate>20090401</startdate><enddate>20090401</enddate><creator>Vivier, Eric</creator><creator>Cupedo, Tom</creator><creator>Spits, Hergen</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>ISR</scope><scope>3V.</scope><scope>7QR</scope><scope>7RV</scope><scope>7T5</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><scope>1XC</scope><orcidid>https://orcid.org/0000-0001-7022-8287</orcidid></search><sort><creationdate>20090401</creationdate><title>Interleukin-22-producing innate immune cells: new players in mucosal immunity and tissue repair?</title><author>Vivier, Eric ; Cupedo, Tom ; Spits, Hergen</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c558t-11bf41c72bc01a8d4a843f6ee40413816631a65a98bda5cdd0a1722ae9f5defd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Animals</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Cell Lineage</topic><topic>Chemokines</topic><topic>Cytokines</topic><topic>Embryos</topic><topic>Genetic aspects</topic><topic>Health aspects</topic><topic>Humans</topic><topic>Immunity</topic><topic>Immunity, Innate</topic><topic>Immunity, Innate - immunology</topic><topic>Immunity, Mucosal</topic><topic>Immunity, Mucosal - immunology</topic><topic>Immunology</topic><topic>Interleukin-22</topic><topic>Interleukins</topic><topic>Interleukins - biosynthesis</topic><topic>Intestinal Mucosa</topic><topic>Intestinal Mucosa - cytology</topic><topic>Intestinal Mucosa - physiology</topic><topic>Killer cells</topic><topic>Killer Cells, Natural</topic><topic>Killer Cells, Natural - cytology</topic><topic>Killer Cells, Natural - physiology</topic><topic>Life Sciences</topic><topic>Lymph nodes</topic><topic>Lymphatic system</topic><topic>Lymphocytes</topic><topic>Lymphocytes - cytology</topic><topic>Lymphocytes - immunology</topic><topic>Lymphocytes - metabolism</topic><topic>Lymphocytes - physiology</topic><topic>Lymphoid Progenitor Cells</topic><topic>Lymphoid Progenitor Cells - cytology</topic><topic>Lymphoid Progenitor Cells - physiology</topic><topic>Lymphoid tissue</topic><topic>Mice</topic><topic>Models, Biological</topic><topic>Palatine Tonsil</topic><topic>Palatine Tonsil - cytology</topic><topic>Palatine Tonsil - physiology</topic><topic>Physiological aspects</topic><topic>progress</topic><topic>Proteins</topic><topic>Regeneration</topic><topic>Regeneration - physiology</topic><topic>Tissues</topic><topic>Tumor necrosis factor-TNF</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Vivier, Eric</creatorcontrib><creatorcontrib>Cupedo, Tom</creatorcontrib><creatorcontrib>Spits, Hergen</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Chemoreception Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><jtitle>Nature reviews. Immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Vivier, Eric</au><au>Cupedo, Tom</au><au>Spits, Hergen</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Interleukin-22-producing innate immune cells: new players in mucosal immunity and tissue repair?</atitle><jtitle>Nature reviews. Immunology</jtitle><stitle>Nat Rev Immunol</stitle><addtitle>Nat Rev Immunol</addtitle><date>2009-04-01</date><risdate>2009</risdate><volume>9</volume><issue>4</issue><spage>229</spage><epage>234</epage><pages>229-234</pages><issn>1474-1733</issn><issn>1474-1741</issn><eissn>1474-1741</eissn><abstract>Recent studies have identified a new population of interleukin-22-producing cells in mucosal tissues that share features with both lymphoid-tissue inducer cells and natural killer cells. How are these three cell populations related and what might be the function of the new cell population?
Mucosal tissues, lying at the interface with the external environment, are constantly challenged by microbial, physical and chemical assaults. To provide the necessary immune defence to such challenges, lymph nodes and Peyer's patches are formed
in utero
in response to inductive signals from lymphoid-tissue inducer (LTi) cells. As discussed in this Progress article, a series of recent reports has identified a population of interleukin-22-producing mucosal cells in the gut and tonsils that share features with both LTi cells (by expressing RORγt) and natural killer cells (by expressing NKp46) and that might be involved in immunity and homeostasis in mucosal tissues.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>19319141</pmid><doi>10.1038/nri2522</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0001-7022-8287</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1474-1733 |
| ispartof | Nature reviews. Immunology, 2009-04, Vol.9 (4), p.229-234 |
| issn | 1474-1733 1474-1741 1474-1741 |
| language | eng |
| recordid | cdi_hal_primary_oai_HAL_hal_00408427v1 |
| source | MEDLINE; Nature; Alma/SFX Local Collection |
| subjects | Animals Biomedical and Life Sciences Biomedicine Cell Lineage Chemokines Cytokines Embryos Genetic aspects Health aspects Humans Immunity Immunity, Innate Immunity, Innate - immunology Immunity, Mucosal Immunity, Mucosal - immunology Immunology Interleukin-22 Interleukins Interleukins - biosynthesis Intestinal Mucosa Intestinal Mucosa - cytology Intestinal Mucosa - physiology Killer cells Killer Cells, Natural Killer Cells, Natural - cytology Killer Cells, Natural - physiology Life Sciences Lymph nodes Lymphatic system Lymphocytes Lymphocytes - cytology Lymphocytes - immunology Lymphocytes - metabolism Lymphocytes - physiology Lymphoid Progenitor Cells Lymphoid Progenitor Cells - cytology Lymphoid Progenitor Cells - physiology Lymphoid tissue Mice Models, Biological Palatine Tonsil Palatine Tonsil - cytology Palatine Tonsil - physiology Physiological aspects progress Proteins Regeneration Regeneration - physiology Tissues Tumor necrosis factor-TNF |
| title | Interleukin-22-producing innate immune cells: new players in mucosal immunity and tissue repair? |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-19T07%3A11%3A00IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_hal_p&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Interleukin-22-producing%20innate%20immune%20cells:%20new%20players%20in%20mucosal%20immunity%20and%20tissue%20repair?&rft.jtitle=Nature%20reviews.%20Immunology&rft.au=Vivier,%20Eric&rft.date=2009-04-01&rft.volume=9&rft.issue=4&rft.spage=229&rft.epage=234&rft.pages=229-234&rft.issn=1474-1733&rft.eissn=1474-1741&rft_id=info:doi/10.1038/nri2522&rft_dat=%3Cgale_hal_p%3EA196964470%3C/gale_hal_p%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=224162039&rft_id=info:pmid/19319141&rft_galeid=A196964470&rfr_iscdi=true |