Decreased blood pressure in NOX1-deficient mice

To understand the role of the superoxide-generating NADPH oxidase NOX1 in the vascular system, we have generated NOX1-deficient mice. NOX1-deficient mice had a moderately decreased basal blood pressure. In response to angiotensin II they showed an almost complete loss of the sustained blood pressure...

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Veröffentlicht in:	FEBS letters 2006-01, Vol.580 (2), p.497-504
Hauptverfasser:	Gavazzi, Gaetan, Banfi, Botond, Deffert, Christine, Fiette, Laurence, Schappi, Michela, Herrmann, Francois, Krause, Karl-Heinz
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiotensin II Angiotensin II - pharmacology Animals Blood Pressure Blood Pressure - drug effects Blood Pressure - physiology Cell Proliferation cross sectional media area CSMA ECM Extracellular Matrix Extracellular Matrix - metabolism Female Hypotension Hypotension - metabolism Life Sciences Male Mice Mice, Inbred C57BL Mice, Knockout Muscle, Smooth, Vascular Muscle, Smooth, Vascular - cytology NADH, NADPH Oxidoreductases NADH, NADPH Oxidoreductases - genetics NADH, NADPH Oxidoreductases - metabolism NADPH oxidase NADPH Oxidase 1 NOX1 Other PCNA proliferative cell nuclear antigen reactive oxygen species ROS SBP Signal Transduction Signal Transduction - physiology systolic blood pressure Tunica Media Tunica Media - anatomy & histology Tunica Media - drug effects Tunica Media - pathology
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