A post-translational modification code for transcription factors: sorting through a sea of signals
Cellular responses to environmental or physiological cues rely on transduction pathways that must ensure discrimination between different signals. These cascades ‘crosstalk’ and lead to a combinatorial regulation. This often results in different combinations of post-translational modifications (PTMs...
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Veröffentlicht in: | Trends in cell biology 2009-05, Vol.19 (5), p.189-197 |
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creator | Benayoun, Bérénice A Veitia, Reiner A |
description | Cellular responses to environmental or physiological cues rely on transduction pathways that must ensure discrimination between different signals. These cascades ‘crosstalk’ and lead to a combinatorial regulation. This often results in different combinations of post-translational modifications (PTMs) on target proteins, which might act as a molecular barcode. Although appealing, the idea of the existence of such a code for transcription factors is debated. Using general arguments and recent evidence, we propose that a PTM code is not only possible but necessary in the context of transcription factors regulating multiple processes. Thus, the coding potential of PTM combinations should both provide a further layer of information integration from several transduction pathways and warrant highly specific cellular outputs. |
doi_str_mv | 10.1016/j.tcb.2009.02.003 |
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subjects | Animals Biochemistry, Molecular Biology Histones - metabolism Humans Life Sciences Molecular biology Pathology Protein Processing, Post-Translational Signal Transduction Transcription Factors - genetics Transcription Factors - metabolism Transcription, Genetic |
title | A post-translational modification code for transcription factors: sorting through a sea of signals |
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