Probing Secondary Carbohydrate−Protein Interactions with Highly Dense Cyclodextrin-Centered Heteroglycoclusters: The Heterocluster Effect

Comparison of the lectin-binding properties for highly dense β-cyclodextrin-centered homo- and heteroglycoclusters with defined architecture provides evidence for the existence of strong synergic effects (heterocluster effect) on carbohydrate−protein recognition events.

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Bibliographische Detailangaben
Veröffentlicht in:	Journal of the American Chemical Society 2005-06, Vol.127 (22), p.7970-7971
Hauptverfasser:	Gómez-García, Marta, Benito, Juan M., Rodríguez-Lucena, David, Yu, Jian-Xin, Chmurski, Kazimierz, Ortiz Mellet, Carmen, Gutiérrez Gallego, Ricardo, Maestre, Alfredo, Defaye, Jacques, García Fernández, José M.
Format:	Artikel
Sprache:	eng
Schlagworte:	beta-Cyclodextrins - chemistry beta-Cyclodextrins - metabolism Biological and medical sciences Carbohydrate Conformation Carbohydrate Metabolism Carbohydrates - chemistry Concanavalin A - chemistry Concanavalin A - metabolism Fundamental and applied biological sciences. Psychology Glucose - chemistry Glucose - metabolism Interactions. Associations Intermolecular phenomena Lactose - chemistry Lactose - metabolism Life Sciences Mannose - chemistry Mannose - metabolism Models, Molecular Molecular biophysics Pharmaceutical sciences Thermodynamics
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Beschreibung
Zusammenfassung:	Comparison of the lectin-binding properties for highly dense β-cyclodextrin-centered homo- and heteroglycoclusters with defined architecture provides evidence for the existence of strong synergic effects (heterocluster effect) on carbohydrate−protein recognition events.
ISSN:	0002-7863 1520-5126
DOI:	10.1021/ja050934t