Protective effect of nitronyl nitroxide–amino acid conjugates on liver ischemia–reperfusion induced injury in rats
Stable nitroxides are potential antioxidant drugs. In this study, we have linked nitroxide to natural amino acids with the aim to improve therapeutic activity. The radical scavenging activities of two nitronyl nitroxide–amino acid conjugates ( NNR and NNK) were evaluated in PC 12 cell survival assay...
Gespeichert in:
| Veröffentlicht in: | Bioorganic & medicinal chemistry 2008-03, Vol.18 (6), p.1788-1794 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1794 |
|---|---|
| container_issue | 6 |
| container_start_page | 1788 |
| container_title | Bioorganic & medicinal chemistry |
| container_volume | 18 |
| creator | Bi, Wei Cai, Jianhui Xue, Ping Zhang, Yanrong Liu, Sanguang Gao, Xiang Li, Meng Wang, Zhibo Baudy-Floc’h, Michèle Green, Sarah A. Bi, Lanrong |
| description | Stable nitroxides are potential antioxidant drugs. In this study, we have linked nitroxide to natural amino acids with the aim to improve therapeutic activity. The radical scavenging activities of two nitronyl nitroxide–amino acid conjugates (
NNR and
NNK) were evaluated in PC 12 cell survival assays. The NO scavenging activities of these compounds were confirmed in the acetylcholine-induced vasorelaxation assay. In addition, the protective effect of
NNR was demonstrated in an in vivo rat model of hepatic ischemia–reperfusion (I/R) induced injury and oxidative change. Because
NNR reduced hepatic I/R injury by minimizing oxidative stress, it might be possible to develop it into a possible therapeutic agent for hepatic I/R injury. |
| doi_str_mv | 10.1016/j.bmcl.2008.02.030 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_hal_p</sourceid><recordid>TN_cdi_hal_primary_oai_HAL_hal_00354757v1</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0960894X08002114</els_id><sourcerecordid>19334172</sourcerecordid><originalsourceid>FETCH-LOGICAL-c515t-d5a582811659cf6640eceff065f083084217ce5b9268fe8f5dc4dc4112fdbdac3</originalsourceid><addsrcrecordid>eNqFkcGKFDEQQIMo7rj6Ax6kLwoeuq2kk-40eFkWdYUBPSh4C5mk4qbp7oxJ97Bz8x_8Q7_EDD2sN4VAFcmrolKPkOcUKgq0edNXu9EMFQOQFbAKanhANpQ3vKw5iIdkA10Dpez4twvyJKUegHLg_DG5oLJmsgXYkMPnGGY0sz9ggc7lrAiumPwcw3Qc1uTOW_z985ce_RQKbbwtTJj65bueMRVhKoZcHAufzC2OXmcy4h6jW5LPj36yi0GbY7_EYw5F1HN6Sh45PSR8do6X5Ov7d1-ub8rtpw8fr6-2pRFUzKUVWkgmKW1EZ1zTcECTp4RGOJA1SM5oa1DsOtZIh9IJa3g-lDJnd1ab-pK8Xvve6kHtox91PKqgvbq52qrTHUAteCvaA83sq5Xdx_BjwTSrMf8Jh0FPGJakWuB5gY34L0i7uua0ZRlkK2hiSCmiux-BgjopVL06KVQnhQqYygpz0Ytz92U3ov1bcnaWgZdnQCejBxf1ZHy65xjkpdCuzdzblcO84IPHqJLxOGUZPmbPygb_rzn-AC1YvXQ</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>19334172</pqid></control><display><type>article</type><title>Protective effect of nitronyl nitroxide–amino acid conjugates on liver ischemia–reperfusion induced injury in rats</title><source>MEDLINE</source><source>Access via ScienceDirect (Elsevier)</source><creator>Bi, Wei ; Cai, Jianhui ; Xue, Ping ; Zhang, Yanrong ; Liu, Sanguang ; Gao, Xiang ; Li, Meng ; Wang, Zhibo ; Baudy-Floc’h, Michèle ; Green, Sarah A. ; Bi, Lanrong</creator><creatorcontrib>Bi, Wei ; Cai, Jianhui ; Xue, Ping ; Zhang, Yanrong ; Liu, Sanguang ; Gao, Xiang ; Li, Meng ; Wang, Zhibo ; Baudy-Floc’h, Michèle ; Green, Sarah A. ; Bi, Lanrong</creatorcontrib><description>Stable nitroxides are potential antioxidant drugs. In this study, we have linked nitroxide to natural amino acids with the aim to improve therapeutic activity. The radical scavenging activities of two nitronyl nitroxide–amino acid conjugates (
NNR and
NNK) were evaluated in PC 12 cell survival assays. The NO scavenging activities of these compounds were confirmed in the acetylcholine-induced vasorelaxation assay. In addition, the protective effect of
NNR was demonstrated in an in vivo rat model of hepatic ischemia–reperfusion (I/R) induced injury and oxidative change. Because
NNR reduced hepatic I/R injury by minimizing oxidative stress, it might be possible to develop it into a possible therapeutic agent for hepatic I/R injury.</description><identifier>ISSN: 0960-894X</identifier><identifier>ISSN: 0968-0896</identifier><identifier>EISSN: 1464-3405</identifier><identifier>EISSN: 1464-3391</identifier><identifier>DOI: 10.1016/j.bmcl.2008.02.030</identifier><identifier>PMID: 18328700</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Acetylcholine - pharmacology ; Alanine Transaminase - metabolism ; Amino Acids - chemical synthesis ; Amino Acids - chemistry ; Amino Acids - pharmacology ; Animals ; Antioxidants - therapeutic use ; Aorta, Thoracic - drug effects ; Aspartate Aminotransferases - metabolism ; Biological and medical sciences ; Cell Survival - drug effects ; Chemical Sciences ; Electron Spin Resonance Spectroscopy ; Endothelium, Vascular - cytology ; Endothelium, Vascular - metabolism ; Free radical scavenger ; Free Radical Scavengers - chemical synthesis ; Free Radical Scavengers - chemistry ; Free Radical Scavengers - pharmacology ; Free Radicals - chemistry ; General and cellular metabolism. Vitamins ; Ischemia–reperfusion injury ; Lipid Peroxidation - drug effects ; Liver - drug effects ; Liver - pathology ; Male ; Malondialdehyde - metabolism ; Medical sciences ; Molecular Structure ; Nitrogen Oxides - chemistry ; Organic chemistry ; Oxidative Stress - drug effects ; PC12 Cells ; Pharmacology. Drug treatments ; Rats ; Rats, Wistar ; Reactive Oxygen Species ; Reperfusion Injury - pathology ; Reperfusion Injury - prevention & control ; Vasodilation - drug effects</subject><ispartof>Bioorganic & medicinal chemistry, 2008-03, Vol.18 (6), p.1788-1794</ispartof><rights>2008 Elsevier Ltd</rights><rights>2008 INIST-CNRS</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c515t-d5a582811659cf6640eceff065f083084217ce5b9268fe8f5dc4dc4112fdbdac3</citedby><cites>FETCH-LOGICAL-c515t-d5a582811659cf6640eceff065f083084217ce5b9268fe8f5dc4dc4112fdbdac3</cites><orcidid>0000-0002-8819-1571 ; 0000-0002-7489-0179</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.bmcl.2008.02.030$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,780,784,885,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20217197$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18328700$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.science/hal-00354757$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Bi, Wei</creatorcontrib><creatorcontrib>Cai, Jianhui</creatorcontrib><creatorcontrib>Xue, Ping</creatorcontrib><creatorcontrib>Zhang, Yanrong</creatorcontrib><creatorcontrib>Liu, Sanguang</creatorcontrib><creatorcontrib>Gao, Xiang</creatorcontrib><creatorcontrib>Li, Meng</creatorcontrib><creatorcontrib>Wang, Zhibo</creatorcontrib><creatorcontrib>Baudy-Floc’h, Michèle</creatorcontrib><creatorcontrib>Green, Sarah A.</creatorcontrib><creatorcontrib>Bi, Lanrong</creatorcontrib><title>Protective effect of nitronyl nitroxide–amino acid conjugates on liver ischemia–reperfusion induced injury in rats</title><title>Bioorganic & medicinal chemistry</title><addtitle>Bioorg Med Chem Lett</addtitle><description>Stable nitroxides are potential antioxidant drugs. In this study, we have linked nitroxide to natural amino acids with the aim to improve therapeutic activity. The radical scavenging activities of two nitronyl nitroxide–amino acid conjugates (
NNR and
NNK) were evaluated in PC 12 cell survival assays. The NO scavenging activities of these compounds were confirmed in the acetylcholine-induced vasorelaxation assay. In addition, the protective effect of
NNR was demonstrated in an in vivo rat model of hepatic ischemia–reperfusion (I/R) induced injury and oxidative change. Because
NNR reduced hepatic I/R injury by minimizing oxidative stress, it might be possible to develop it into a possible therapeutic agent for hepatic I/R injury.</description><subject>Acetylcholine - pharmacology</subject><subject>Alanine Transaminase - metabolism</subject><subject>Amino Acids - chemical synthesis</subject><subject>Amino Acids - chemistry</subject><subject>Amino Acids - pharmacology</subject><subject>Animals</subject><subject>Antioxidants - therapeutic use</subject><subject>Aorta, Thoracic - drug effects</subject><subject>Aspartate Aminotransferases - metabolism</subject><subject>Biological and medical sciences</subject><subject>Cell Survival - drug effects</subject><subject>Chemical Sciences</subject><subject>Electron Spin Resonance Spectroscopy</subject><subject>Endothelium, Vascular - cytology</subject><subject>Endothelium, Vascular - metabolism</subject><subject>Free radical scavenger</subject><subject>Free Radical Scavengers - chemical synthesis</subject><subject>Free Radical Scavengers - chemistry</subject><subject>Free Radical Scavengers - pharmacology</subject><subject>Free Radicals - chemistry</subject><subject>General and cellular metabolism. Vitamins</subject><subject>Ischemia–reperfusion injury</subject><subject>Lipid Peroxidation - drug effects</subject><subject>Liver - drug effects</subject><subject>Liver - pathology</subject><subject>Male</subject><subject>Malondialdehyde - metabolism</subject><subject>Medical sciences</subject><subject>Molecular Structure</subject><subject>Nitrogen Oxides - chemistry</subject><subject>Organic chemistry</subject><subject>Oxidative Stress - drug effects</subject><subject>PC12 Cells</subject><subject>Pharmacology. Drug treatments</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Reactive Oxygen Species</subject><subject>Reperfusion Injury - pathology</subject><subject>Reperfusion Injury - prevention & control</subject><subject>Vasodilation - drug effects</subject><issn>0960-894X</issn><issn>0968-0896</issn><issn>1464-3405</issn><issn>1464-3391</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkcGKFDEQQIMo7rj6Ax6kLwoeuq2kk-40eFkWdYUBPSh4C5mk4qbp7oxJ97Bz8x_8Q7_EDD2sN4VAFcmrolKPkOcUKgq0edNXu9EMFQOQFbAKanhANpQ3vKw5iIdkA10Dpez4twvyJKUegHLg_DG5oLJmsgXYkMPnGGY0sz9ggc7lrAiumPwcw3Qc1uTOW_z985ce_RQKbbwtTJj65bueMRVhKoZcHAufzC2OXmcy4h6jW5LPj36yi0GbY7_EYw5F1HN6Sh45PSR8do6X5Ov7d1-ub8rtpw8fr6-2pRFUzKUVWkgmKW1EZ1zTcECTp4RGOJA1SM5oa1DsOtZIh9IJa3g-lDJnd1ab-pK8Xvve6kHtox91PKqgvbq52qrTHUAteCvaA83sq5Xdx_BjwTSrMf8Jh0FPGJakWuB5gY34L0i7uua0ZRlkK2hiSCmiux-BgjopVL06KVQnhQqYygpz0Ytz92U3ov1bcnaWgZdnQCejBxf1ZHy65xjkpdCuzdzblcO84IPHqJLxOGUZPmbPygb_rzn-AC1YvXQ</recordid><startdate>20080315</startdate><enddate>20080315</enddate><creator>Bi, Wei</creator><creator>Cai, Jianhui</creator><creator>Xue, Ping</creator><creator>Zhang, Yanrong</creator><creator>Liu, Sanguang</creator><creator>Gao, Xiang</creator><creator>Li, Meng</creator><creator>Wang, Zhibo</creator><creator>Baudy-Floc’h, Michèle</creator><creator>Green, Sarah A.</creator><creator>Bi, Lanrong</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope><scope>1XC</scope><orcidid>https://orcid.org/0000-0002-8819-1571</orcidid><orcidid>https://orcid.org/0000-0002-7489-0179</orcidid></search><sort><creationdate>20080315</creationdate><title>Protective effect of nitronyl nitroxide–amino acid conjugates on liver ischemia–reperfusion induced injury in rats</title><author>Bi, Wei ; Cai, Jianhui ; Xue, Ping ; Zhang, Yanrong ; Liu, Sanguang ; Gao, Xiang ; Li, Meng ; Wang, Zhibo ; Baudy-Floc’h, Michèle ; Green, Sarah A. ; Bi, Lanrong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c515t-d5a582811659cf6640eceff065f083084217ce5b9268fe8f5dc4dc4112fdbdac3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Acetylcholine - pharmacology</topic><topic>Alanine Transaminase - metabolism</topic><topic>Amino Acids - chemical synthesis</topic><topic>Amino Acids - chemistry</topic><topic>Amino Acids - pharmacology</topic><topic>Animals</topic><topic>Antioxidants - therapeutic use</topic><topic>Aorta, Thoracic - drug effects</topic><topic>Aspartate Aminotransferases - metabolism</topic><topic>Biological and medical sciences</topic><topic>Cell Survival - drug effects</topic><topic>Chemical Sciences</topic><topic>Electron Spin Resonance Spectroscopy</topic><topic>Endothelium, Vascular - cytology</topic><topic>Endothelium, Vascular - metabolism</topic><topic>Free radical scavenger</topic><topic>Free Radical Scavengers - chemical synthesis</topic><topic>Free Radical Scavengers - chemistry</topic><topic>Free Radical Scavengers - pharmacology</topic><topic>Free Radicals - chemistry</topic><topic>General and cellular metabolism. Vitamins</topic><topic>Ischemia–reperfusion injury</topic><topic>Lipid Peroxidation - drug effects</topic><topic>Liver - drug effects</topic><topic>Liver - pathology</topic><topic>Male</topic><topic>Malondialdehyde - metabolism</topic><topic>Medical sciences</topic><topic>Molecular Structure</topic><topic>Nitrogen Oxides - chemistry</topic><topic>Organic chemistry</topic><topic>Oxidative Stress - drug effects</topic><topic>PC12 Cells</topic><topic>Pharmacology. Drug treatments</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Reactive Oxygen Species</topic><topic>Reperfusion Injury - pathology</topic><topic>Reperfusion Injury - prevention & control</topic><topic>Vasodilation - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bi, Wei</creatorcontrib><creatorcontrib>Cai, Jianhui</creatorcontrib><creatorcontrib>Xue, Ping</creatorcontrib><creatorcontrib>Zhang, Yanrong</creatorcontrib><creatorcontrib>Liu, Sanguang</creatorcontrib><creatorcontrib>Gao, Xiang</creatorcontrib><creatorcontrib>Li, Meng</creatorcontrib><creatorcontrib>Wang, Zhibo</creatorcontrib><creatorcontrib>Baudy-Floc’h, Michèle</creatorcontrib><creatorcontrib>Green, Sarah A.</creatorcontrib><creatorcontrib>Bi, Lanrong</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><jtitle>Bioorganic & medicinal chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bi, Wei</au><au>Cai, Jianhui</au><au>Xue, Ping</au><au>Zhang, Yanrong</au><au>Liu, Sanguang</au><au>Gao, Xiang</au><au>Li, Meng</au><au>Wang, Zhibo</au><au>Baudy-Floc’h, Michèle</au><au>Green, Sarah A.</au><au>Bi, Lanrong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Protective effect of nitronyl nitroxide–amino acid conjugates on liver ischemia–reperfusion induced injury in rats</atitle><jtitle>Bioorganic & medicinal chemistry</jtitle><addtitle>Bioorg Med Chem Lett</addtitle><date>2008-03-15</date><risdate>2008</risdate><volume>18</volume><issue>6</issue><spage>1788</spage><epage>1794</epage><pages>1788-1794</pages><issn>0960-894X</issn><issn>0968-0896</issn><eissn>1464-3405</eissn><eissn>1464-3391</eissn><abstract>Stable nitroxides are potential antioxidant drugs. In this study, we have linked nitroxide to natural amino acids with the aim to improve therapeutic activity. The radical scavenging activities of two nitronyl nitroxide–amino acid conjugates (
NNR and
NNK) were evaluated in PC 12 cell survival assays. The NO scavenging activities of these compounds were confirmed in the acetylcholine-induced vasorelaxation assay. In addition, the protective effect of
NNR was demonstrated in an in vivo rat model of hepatic ischemia–reperfusion (I/R) induced injury and oxidative change. Because
NNR reduced hepatic I/R injury by minimizing oxidative stress, it might be possible to develop it into a possible therapeutic agent for hepatic I/R injury.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>18328700</pmid><doi>10.1016/j.bmcl.2008.02.030</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-8819-1571</orcidid><orcidid>https://orcid.org/0000-0002-7489-0179</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0960-894X |
| ispartof | Bioorganic & medicinal chemistry, 2008-03, Vol.18 (6), p.1788-1794 |
| issn | 0960-894X 0968-0896 1464-3405 1464-3391 |
| language | eng |
| recordid | cdi_hal_primary_oai_HAL_hal_00354757v1 |
| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Acetylcholine - pharmacology Alanine Transaminase - metabolism Amino Acids - chemical synthesis Amino Acids - chemistry Amino Acids - pharmacology Animals Antioxidants - therapeutic use Aorta, Thoracic - drug effects Aspartate Aminotransferases - metabolism Biological and medical sciences Cell Survival - drug effects Chemical Sciences Electron Spin Resonance Spectroscopy Endothelium, Vascular - cytology Endothelium, Vascular - metabolism Free radical scavenger Free Radical Scavengers - chemical synthesis Free Radical Scavengers - chemistry Free Radical Scavengers - pharmacology Free Radicals - chemistry General and cellular metabolism. Vitamins Ischemia–reperfusion injury Lipid Peroxidation - drug effects Liver - drug effects Liver - pathology Male Malondialdehyde - metabolism Medical sciences Molecular Structure Nitrogen Oxides - chemistry Organic chemistry Oxidative Stress - drug effects PC12 Cells Pharmacology. Drug treatments Rats Rats, Wistar Reactive Oxygen Species Reperfusion Injury - pathology Reperfusion Injury - prevention & control Vasodilation - drug effects |
| title | Protective effect of nitronyl nitroxide–amino acid conjugates on liver ischemia–reperfusion induced injury in rats |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-28T19%3A54%3A09IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_hal_p&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Protective%20effect%20of%20nitronyl%20nitroxide%E2%80%93amino%20acid%20conjugates%20on%20liver%20ischemia%E2%80%93reperfusion%20induced%20injury%20in%20rats&rft.jtitle=Bioorganic%20&%20medicinal%20chemistry&rft.au=Bi,%20Wei&rft.date=2008-03-15&rft.volume=18&rft.issue=6&rft.spage=1788&rft.epage=1794&rft.pages=1788-1794&rft.issn=0960-894X&rft.eissn=1464-3405&rft_id=info:doi/10.1016/j.bmcl.2008.02.030&rft_dat=%3Cproquest_hal_p%3E19334172%3C/proquest_hal_p%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=19334172&rft_id=info:pmid/18328700&rft_els_id=S0960894X08002114&rfr_iscdi=true |