Contribution of Sinerem® used as blood-pool contrast agent: Detection of cerebral blood volume changes during apnea in the rabbit
The authors suggest that ultra‐small paramagnetic iron oxide (USPIO) particles used as blood pool contrast agents may increase the sensitivity of midfield MRI (i.e., less than 1.5 Tesla) to physiological variations in cerebral blood volume. This hypothesis was tested on a rabbit model of apnea which...
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| Veröffentlicht in: | Magnetic resonance in medicine 1996-09, Vol.36 (3), p.415-419 |
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| container_title | Magnetic resonance in medicine |
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| creator | Berry, Isabelle Benderbous, Soraya Ranjeva, Jean-Philippe Gracia-Meavilla, Dominique Manelfe, Claude Le Bihan, D. |
| description | The authors suggest that ultra‐small paramagnetic iron oxide (USPIO) particles used as blood pool contrast agents may increase the sensitivity of midfield MRI (i.e., less than 1.5 Tesla) to physiological variations in cerebral blood volume. This hypothesis was tested on a rabbit model of apnea which increases pCO2 and cerebral blood volume. Using Sinerem® as the USPIO at a blood concentration of 60 μmol iron/kg body weight, an 8% T2*‐weighted signal decrease could be observed at 1.0 T with 25–33% increase in pCO2. Comparatively, in the absence of USPIO, T2*‐weighted signal dropped only 4% during apnea and after mild hyperoxygenation beforehand, due to increased deoxyhemoglobin content. These preliminary data suggest that USPIOs could play an important role in functional MRI at midfield strength, by sensitizing the signal to cerebral blood volume changes. |
| doi_str_mv | 10.1002/mrm.1910360313 |
| format | Article |
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This hypothesis was tested on a rabbit model of apnea which increases pCO2 and cerebral blood volume. Using Sinerem® as the USPIO at a blood concentration of 60 μmol iron/kg body weight, an 8% T2*‐weighted signal decrease could be observed at 1.0 T with 25–33% increase in pCO2. Comparatively, in the absence of USPIO, T2*‐weighted signal dropped only 4% during apnea and after mild hyperoxygenation beforehand, due to increased deoxyhemoglobin content. These preliminary data suggest that USPIOs could play an important role in functional MRI at midfield strength, by sensitizing the signal to cerebral blood volume changes.</description><identifier>ISSN: 0740-3194</identifier><identifier>EISSN: 1522-2594</identifier><identifier>DOI: 10.1002/mrm.1910360313</identifier><identifier>PMID: 8875412</identifier><identifier>CODEN: MRMEEN</identifier><language>eng</language><publisher>Baltimore: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>animal model ; Animals ; Apnea ; Apnea - pathology ; Bioengineering ; Biological and medical sciences ; blood pool contrast agent ; Blood Volume ; cerebral blood volume ; Cerebrovascular Circulation ; Contrast Media ; Dextrans ; Ferrosoferric Oxide ; functional magnetic resonance imaging ; Imaging ; Investigative techniques, diagnostic techniques (general aspects) ; Iron ; Life Sciences ; Magnetic Resonance Imaging ; Magnetite Nanoparticles ; Medical sciences ; Miscellaneous. Technology ; Oxides ; Rabbits ; Radiodiagnosis. Nmr imagery. Nmr spectrometry</subject><ispartof>Magnetic resonance in medicine, 1996-09, Vol.36 (3), p.415-419</ispartof><rights>Copyright © 1996 Wiley‐Liss, Inc., A Wiley Company</rights><rights>1996 INIST-CNRS</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4413-e901752b9ab2074712c3e7f75500d90a3efab062f636461e5870e6f9c64e5bb33</citedby><cites>FETCH-LOGICAL-c4413-e901752b9ab2074712c3e7f75500d90a3efab062f636461e5870e6f9c64e5bb33</cites><orcidid>0000-0002-0886-3252</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fmrm.1910360313$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fmrm.1910360313$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,314,776,780,881,1411,27903,27904,45553,45554</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3217229$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8875412$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.science/hal-00349957$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Berry, Isabelle</creatorcontrib><creatorcontrib>Benderbous, Soraya</creatorcontrib><creatorcontrib>Ranjeva, Jean-Philippe</creatorcontrib><creatorcontrib>Gracia-Meavilla, Dominique</creatorcontrib><creatorcontrib>Manelfe, Claude</creatorcontrib><creatorcontrib>Le Bihan, D.</creatorcontrib><title>Contribution of Sinerem® used as blood-pool contrast agent: Detection of cerebral blood volume changes during apnea in the rabbit</title><title>Magnetic resonance in medicine</title><addtitle>Magn. Reson. Med</addtitle><description>The authors suggest that ultra‐small paramagnetic iron oxide (USPIO) particles used as blood pool contrast agents may increase the sensitivity of midfield MRI (i.e., less than 1.5 Tesla) to physiological variations in cerebral blood volume. This hypothesis was tested on a rabbit model of apnea which increases pCO2 and cerebral blood volume. Using Sinerem® as the USPIO at a blood concentration of 60 μmol iron/kg body weight, an 8% T2*‐weighted signal decrease could be observed at 1.0 T with 25–33% increase in pCO2. Comparatively, in the absence of USPIO, T2*‐weighted signal dropped only 4% during apnea and after mild hyperoxygenation beforehand, due to increased deoxyhemoglobin content. These preliminary data suggest that USPIOs could play an important role in functional MRI at midfield strength, by sensitizing the signal to cerebral blood volume changes.</description><subject>animal model</subject><subject>Animals</subject><subject>Apnea</subject><subject>Apnea - pathology</subject><subject>Bioengineering</subject><subject>Biological and medical sciences</subject><subject>blood pool contrast agent</subject><subject>Blood Volume</subject><subject>cerebral blood volume</subject><subject>Cerebrovascular Circulation</subject><subject>Contrast Media</subject><subject>Dextrans</subject><subject>Ferrosoferric Oxide</subject><subject>functional magnetic resonance imaging</subject><subject>Imaging</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Iron</subject><subject>Life Sciences</subject><subject>Magnetic Resonance Imaging</subject><subject>Magnetite Nanoparticles</subject><subject>Medical sciences</subject><subject>Miscellaneous. Technology</subject><subject>Oxides</subject><subject>Rabbits</subject><subject>Radiodiagnosis. Nmr imagery. Nmr spectrometry</subject><issn>0740-3194</issn><issn>1522-2594</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc1u1DAURiMEKkNhyw7JC4TEIoN_45hdNUCLNAWpFFhatudmxuDEUzspdMsD8RB9smaUYRArVpZ8z_l8ra8onhI8JxjTV21q50QRzCrMCLtXzIigtKRC8fvFDEuOS0YUf1g8yvkbxlgpyY-Ko7qWghM6K34tYtcnb4fexw7FBn3yHSRob3-jIcMKmYxsiHFVbmMMyO1gk3tk1tD1r9Eb6MH9Md3o2WTCJKDrGIYWkNuYbg0ZrYbkuzUy2w4M8h3qN4CSsdb3j4sHjQkZnuzP4-Lzu7eXi7Ny-fH0_eJkWTrOCStBYSIFtcpYOv5LEuoYyEYKgfFKYcOgMRZXtKlYxSsCopYYqka5ioOwlrHj4uWUuzFBb5NvTbrR0Xh9drLUuzuMGVdKyGsysi8mdpvi1QC5163PDkIwHcQha1lzwep6FzqfQJdizgmaQzLBeleQHgvSfwsahWf75MG2sDrg-0bG-fP93GRnQpNM53w-YIwSSakaMTVhP3yAm_88qs8vzv9ZoZxcn3v4eXBN-q4ryaTQXz-canF5sVww_EUTdgfsEbjd</recordid><startdate>199609</startdate><enddate>199609</enddate><creator>Berry, Isabelle</creator><creator>Benderbous, Soraya</creator><creator>Ranjeva, Jean-Philippe</creator><creator>Gracia-Meavilla, Dominique</creator><creator>Manelfe, Claude</creator><creator>Le Bihan, D.</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Williams & Wilkins</general><general>Wiley</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>1XC</scope><orcidid>https://orcid.org/0000-0002-0886-3252</orcidid></search><sort><creationdate>199609</creationdate><title>Contribution of Sinerem® used as blood-pool contrast agent: Detection of cerebral blood volume changes during apnea in the rabbit</title><author>Berry, Isabelle ; Benderbous, Soraya ; Ranjeva, Jean-Philippe ; Gracia-Meavilla, Dominique ; Manelfe, Claude ; Le Bihan, D.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4413-e901752b9ab2074712c3e7f75500d90a3efab062f636461e5870e6f9c64e5bb33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>animal model</topic><topic>Animals</topic><topic>Apnea</topic><topic>Apnea - pathology</topic><topic>Bioengineering</topic><topic>Biological and medical sciences</topic><topic>blood pool contrast agent</topic><topic>Blood Volume</topic><topic>cerebral blood volume</topic><topic>Cerebrovascular Circulation</topic><topic>Contrast Media</topic><topic>Dextrans</topic><topic>Ferrosoferric Oxide</topic><topic>functional magnetic resonance imaging</topic><topic>Imaging</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Iron</topic><topic>Life Sciences</topic><topic>Magnetic Resonance Imaging</topic><topic>Magnetite Nanoparticles</topic><topic>Medical sciences</topic><topic>Miscellaneous. Technology</topic><topic>Oxides</topic><topic>Rabbits</topic><topic>Radiodiagnosis. Nmr imagery. Nmr spectrometry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Berry, Isabelle</creatorcontrib><creatorcontrib>Benderbous, Soraya</creatorcontrib><creatorcontrib>Ranjeva, Jean-Philippe</creatorcontrib><creatorcontrib>Gracia-Meavilla, Dominique</creatorcontrib><creatorcontrib>Manelfe, Claude</creatorcontrib><creatorcontrib>Le Bihan, D.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><jtitle>Magnetic resonance in medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Berry, Isabelle</au><au>Benderbous, Soraya</au><au>Ranjeva, Jean-Philippe</au><au>Gracia-Meavilla, Dominique</au><au>Manelfe, Claude</au><au>Le Bihan, D.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Contribution of Sinerem® used as blood-pool contrast agent: Detection of cerebral blood volume changes during apnea in the rabbit</atitle><jtitle>Magnetic resonance in medicine</jtitle><addtitle>Magn. Reson. Med</addtitle><date>1996-09</date><risdate>1996</risdate><volume>36</volume><issue>3</issue><spage>415</spage><epage>419</epage><pages>415-419</pages><issn>0740-3194</issn><eissn>1522-2594</eissn><coden>MRMEEN</coden><abstract>The authors suggest that ultra‐small paramagnetic iron oxide (USPIO) particles used as blood pool contrast agents may increase the sensitivity of midfield MRI (i.e., less than 1.5 Tesla) to physiological variations in cerebral blood volume. This hypothesis was tested on a rabbit model of apnea which increases pCO2 and cerebral blood volume. Using Sinerem® as the USPIO at a blood concentration of 60 μmol iron/kg body weight, an 8% T2*‐weighted signal decrease could be observed at 1.0 T with 25–33% increase in pCO2. Comparatively, in the absence of USPIO, T2*‐weighted signal dropped only 4% during apnea and after mild hyperoxygenation beforehand, due to increased deoxyhemoglobin content. These preliminary data suggest that USPIOs could play an important role in functional MRI at midfield strength, by sensitizing the signal to cerebral blood volume changes.</abstract><cop>Baltimore</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>8875412</pmid><doi>10.1002/mrm.1910360313</doi><tpages>5</tpages><orcidid>https://orcid.org/0000-0002-0886-3252</orcidid></addata></record> |
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| ispartof | Magnetic resonance in medicine, 1996-09, Vol.36 (3), p.415-419 |
| issn | 0740-3194 1522-2594 |
| language | eng |
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| source | Wiley Online Library - AutoHoldings Journals; MEDLINE |
| subjects | animal model Animals Apnea Apnea - pathology Bioengineering Biological and medical sciences blood pool contrast agent Blood Volume cerebral blood volume Cerebrovascular Circulation Contrast Media Dextrans Ferrosoferric Oxide functional magnetic resonance imaging Imaging Investigative techniques, diagnostic techniques (general aspects) Iron Life Sciences Magnetic Resonance Imaging Magnetite Nanoparticles Medical sciences Miscellaneous. Technology Oxides Rabbits Radiodiagnosis. Nmr imagery. Nmr spectrometry |
| title | Contribution of Sinerem® used as blood-pool contrast agent: Detection of cerebral blood volume changes during apnea in the rabbit |
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