HIV-1 gp41 fusogenic function triggers autophagy in uninfected cells

Cell-expressed HIV-1 envelope glycoproteins (gp120 and gp41, called Env) induce autophagy in uninfected CD4 T cells, leading to their apoptosis, a mechanism most likely contributing to immunodeficiency. The presence of CD4 and CXCR4 on target cells is required for this process, but Env-induced autop...

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Veröffentlicht in:	Autophagy 2008-11, Vol.4 (8), p.998-1008
Hauptverfasser:	Denizot, Mélanie, Varbanov, Mihayl, Espert, Lucile, Robert-Hebmann, Véronique, Sagnier, Sophie, Elisabet Garcia, Elisabet Garcia, Curriu, Marta, Mamoun, Robert, Blanco, Julià, Biard-Piechaczyk, Martine
Format:	Artikel
Sprache:	eng
Schlagworte:	Autophagy Binding Biology Bioscience Calcium Cancer CD4 Antigens - genetics CD4 Antigens - immunology CD4-Positive T-Lymphocytes - immunology CD4-Positive T-Lymphocytes - ultrastructure Cell Cell Line Coculture Techniques Cycle HIV Envelope Protein gp41 - genetics HIV Envelope Protein gp41 - immunology HIV Infections - immunology HIV-1 - immunology HIV-1 - physiology Humans Landes Life Sciences Microbiology and Parasitology Microscopy, Electron, Transmission Organogenesis Proteins Receptors, CXCR4 - genetics Receptors, CXCR4 - immunology Viral Fusion Proteins - immunology Virology Virus Internalization
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