5-LOX, 12-LOX and 15-LOX in immature forms of human leukemic blasts

Abstract Several reports have demonstrated an important role of leukotriene B4 (LTB4 ) in the immune system. We investigated whether leukemic blasts from acute myeloid leukemic (AML) and acute lymphoid leukemic (ALL) patients produced LTB4 , 12- and 15-hydroxyeicosatetraenoic acids (12-HETE and 15-H...

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Veröffentlicht in:	Leukemia research 2008-11, Vol.32 (11), p.1756-1762
Hauptverfasser:	Vincent, Christelle, Fiancette, Rémi, Donnard, Magali, Bordessoule, Dominique, Turlure, Pascal, Trimoreau, Franck, Denizot, Yves
Format:	Artikel
Sprache:	eng
Schlagworte:	12-HETE 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid - secretion 12-LOX 15-HETE 15-LOX 5-LOX Apoptosis Apoptosis - physiology Arachidonate 12-Lipoxygenase Arachidonate 12-Lipoxygenase - genetics Arachidonate 12-Lipoxygenase - metabolism Arachidonate 15-Lipoxygenase Arachidonate 15-Lipoxygenase - genetics Arachidonate 15-Lipoxygenase - metabolism Arachidonate 5-Lipoxygenase Arachidonate 5-Lipoxygenase - genetics Arachidonate 5-Lipoxygenase - metabolism Arachidonic Acid Arachidonic Acid - metabolism Blast Crisis Blast Crisis - classification Blast Crisis - enzymology Blast Crisis - pathology Calcium Calcium - metabolism Cell Proliferation Hematology, Oncology and Palliative Medicine Human leukemic blasts Humans Hydroxyeicosatetraenoic Acids Hydroxyeicosatetraenoic Acids - secretion Immunology Ionophores Ionophores - pharmacology Leukemia, Myeloid, Acute Leukemia, Myeloid, Acute - classification Leukemia, Myeloid, Acute - enzymology Leukemia, Myeloid, Acute - pathology Leukotriene B4 Leukotriene B4 - secretion Life Sciences Lipoxygenase LTB 4 Polymerase Chain Reaction Precursor Cell Lymphoblastic Leukemia-Lymphoma Precursor Cell Lymphoblastic Leukemia-Lymphoma - classification Precursor Cell Lymphoblastic Leukemia-Lymphoma - enzymology Precursor Cell Lymphoblastic Leukemia-Lymphoma - pathology RNA, Messenger RNA, Messenger - genetics RNA, Messenger - metabolism Thromboxane A2 Thromboxane A2 - secretion
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