5-LOX, 12-LOX and 15-LOX in immature forms of human leukemic blasts
Abstract Several reports have demonstrated an important role of leukotriene B4 (LTB4 ) in the immune system. We investigated whether leukemic blasts from acute myeloid leukemic (AML) and acute lymphoid leukemic (ALL) patients produced LTB4 , 12- and 15-hydroxyeicosatetraenoic acids (12-HETE and 15-H...
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| Veröffentlicht in: | Leukemia research 2008-11, Vol.32 (11), p.1756-1762 |
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| creator | Vincent, Christelle Fiancette, Rémi Donnard, Magali Bordessoule, Dominique Turlure, Pascal Trimoreau, Franck Denizot, Yves |
| description | Abstract Several reports have demonstrated an important role of leukotriene B4 (LTB4 ) in the immune system. We investigated whether leukemic blasts from acute myeloid leukemic (AML) and acute lymphoid leukemic (ALL) patients produced LTB4 , 12- and 15-hydroxyeicosatetraenoic acids (12-HETE and 15-HETE) and whether these compounds affected blast proliferation and apoptosis. Leukemic blasts from AML M0-2 and ALL patients expressed 5-LOX, 12-LOX and 15-LOX transcripts. Quantitative polymerase chain reaction indicated that 5-LOX transcripts were far more abundant than 12-LOX and 15-LOX ones. Leukemic blasts expressed 5-LOX activating protein (FLAP) transcripts and produced LTB4 in response to calcium ionophore. In contrast no 15-HETE production was found. Calcium ionophore-stimulated leukemic blasts produced 12-HETE but also released thromboxane A2 suggesting that contaminating platelets accounted for the release of these compounds. No significant effect of LTB4 , 12-HETE or 15-HETE could be documented on leukemic blast growth and on their apoptose rate. Results of the present study indicate that immature form of leukemic blasts produce LTB4 . However, the three major lipoxygenase metabolites of arachidonic acid; i.e., LTB4 , 12-HETE or 15-HETE, had no evident effect on their growth and apoptosis. We may speculate that LTB4 -derived blast cells might initiate, augment or prolong tissue inflammation and damages by affecting the marrow and blood cytokine network. |
| doi_str_mv | 10.1016/j.leukres.2008.05.005 |
| format | Article |
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We investigated whether leukemic blasts from acute myeloid leukemic (AML) and acute lymphoid leukemic (ALL) patients produced LTB4 , 12- and 15-hydroxyeicosatetraenoic acids (12-HETE and 15-HETE) and whether these compounds affected blast proliferation and apoptosis. Leukemic blasts from AML M0-2 and ALL patients expressed 5-LOX, 12-LOX and 15-LOX transcripts. Quantitative polymerase chain reaction indicated that 5-LOX transcripts were far more abundant than 12-LOX and 15-LOX ones. Leukemic blasts expressed 5-LOX activating protein (FLAP) transcripts and produced LTB4 in response to calcium ionophore. In contrast no 15-HETE production was found. Calcium ionophore-stimulated leukemic blasts produced 12-HETE but also released thromboxane A2 suggesting that contaminating platelets accounted for the release of these compounds. No significant effect of LTB4 , 12-HETE or 15-HETE could be documented on leukemic blast growth and on their apoptose rate. Results of the present study indicate that immature form of leukemic blasts produce LTB4 . However, the three major lipoxygenase metabolites of arachidonic acid; i.e., LTB4 , 12-HETE or 15-HETE, had no evident effect on their growth and apoptosis. We may speculate that LTB4 -derived blast cells might initiate, augment or prolong tissue inflammation and damages by affecting the marrow and blood cytokine network.</description><identifier>ISSN: 0145-2126</identifier><identifier>EISSN: 1873-5835</identifier><identifier>EISSN: 0145-2126</identifier><identifier>DOI: 10.1016/j.leukres.2008.05.005</identifier><identifier>PMID: 18561999</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>12-HETE ; 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid ; 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid - secretion ; 12-LOX ; 15-HETE ; 15-LOX ; 5-LOX ; Apoptosis ; Apoptosis - physiology ; Arachidonate 12-Lipoxygenase ; Arachidonate 12-Lipoxygenase - genetics ; Arachidonate 12-Lipoxygenase - metabolism ; Arachidonate 15-Lipoxygenase ; Arachidonate 15-Lipoxygenase - genetics ; Arachidonate 15-Lipoxygenase - metabolism ; Arachidonate 5-Lipoxygenase ; Arachidonate 5-Lipoxygenase - genetics ; Arachidonate 5-Lipoxygenase - metabolism ; Arachidonic Acid ; Arachidonic Acid - metabolism ; Blast Crisis ; Blast Crisis - classification ; Blast Crisis - enzymology ; Blast Crisis - pathology ; Calcium ; Calcium - metabolism ; Cell Proliferation ; Hematology, Oncology and Palliative Medicine ; Human leukemic blasts ; Humans ; Hydroxyeicosatetraenoic Acids ; Hydroxyeicosatetraenoic Acids - secretion ; Immunology ; Ionophores ; Ionophores - pharmacology ; Leukemia, Myeloid, Acute ; Leukemia, Myeloid, Acute - classification ; Leukemia, Myeloid, Acute - enzymology ; Leukemia, Myeloid, Acute - pathology ; Leukotriene B4 ; Leukotriene B4 - secretion ; Life Sciences ; Lipoxygenase ; LTB 4 ; Polymerase Chain Reaction ; Precursor Cell Lymphoblastic Leukemia-Lymphoma ; Precursor Cell Lymphoblastic Leukemia-Lymphoma - classification ; Precursor Cell Lymphoblastic Leukemia-Lymphoma - enzymology ; Precursor Cell Lymphoblastic Leukemia-Lymphoma - pathology ; RNA, Messenger ; RNA, Messenger - genetics ; RNA, Messenger - metabolism ; Thromboxane A2 ; Thromboxane A2 - secretion</subject><ispartof>Leukemia research, 2008-11, Vol.32 (11), p.1756-1762</ispartof><rights>Elsevier Ltd</rights><rights>2008 Elsevier Ltd</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c483t-483677be930342bcf8336808ae4059d7b677f7ffd232d6c9827efcb90566413e3</citedby><cites>FETCH-LOGICAL-c483t-483677be930342bcf8336808ae4059d7b677f7ffd232d6c9827efcb90566413e3</cites><orcidid>0000-0002-5799-980X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0145212608002440$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,776,780,881,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18561999$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.science/hal-00344827$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Vincent, Christelle</creatorcontrib><creatorcontrib>Fiancette, Rémi</creatorcontrib><creatorcontrib>Donnard, Magali</creatorcontrib><creatorcontrib>Bordessoule, Dominique</creatorcontrib><creatorcontrib>Turlure, Pascal</creatorcontrib><creatorcontrib>Trimoreau, Franck</creatorcontrib><creatorcontrib>Denizot, Yves</creatorcontrib><title>5-LOX, 12-LOX and 15-LOX in immature forms of human leukemic blasts</title><title>Leukemia research</title><addtitle>Leuk Res</addtitle><description>Abstract Several reports have demonstrated an important role of leukotriene B4 (LTB4 ) in the immune system. We investigated whether leukemic blasts from acute myeloid leukemic (AML) and acute lymphoid leukemic (ALL) patients produced LTB4 , 12- and 15-hydroxyeicosatetraenoic acids (12-HETE and 15-HETE) and whether these compounds affected blast proliferation and apoptosis. Leukemic blasts from AML M0-2 and ALL patients expressed 5-LOX, 12-LOX and 15-LOX transcripts. Quantitative polymerase chain reaction indicated that 5-LOX transcripts were far more abundant than 12-LOX and 15-LOX ones. Leukemic blasts expressed 5-LOX activating protein (FLAP) transcripts and produced LTB4 in response to calcium ionophore. In contrast no 15-HETE production was found. Calcium ionophore-stimulated leukemic blasts produced 12-HETE but also released thromboxane A2 suggesting that contaminating platelets accounted for the release of these compounds. No significant effect of LTB4 , 12-HETE or 15-HETE could be documented on leukemic blast growth and on their apoptose rate. Results of the present study indicate that immature form of leukemic blasts produce LTB4 . However, the three major lipoxygenase metabolites of arachidonic acid; i.e., LTB4 , 12-HETE or 15-HETE, had no evident effect on their growth and apoptosis. We may speculate that LTB4 -derived blast cells might initiate, augment or prolong tissue inflammation and damages by affecting the marrow and blood cytokine network.</description><subject>12-HETE</subject><subject>12-Hydroxy-5,8,10,14-eicosatetraenoic Acid</subject><subject>12-Hydroxy-5,8,10,14-eicosatetraenoic Acid - secretion</subject><subject>12-LOX</subject><subject>15-HETE</subject><subject>15-LOX</subject><subject>5-LOX</subject><subject>Apoptosis</subject><subject>Apoptosis - physiology</subject><subject>Arachidonate 12-Lipoxygenase</subject><subject>Arachidonate 12-Lipoxygenase - genetics</subject><subject>Arachidonate 12-Lipoxygenase - metabolism</subject><subject>Arachidonate 15-Lipoxygenase</subject><subject>Arachidonate 15-Lipoxygenase - genetics</subject><subject>Arachidonate 15-Lipoxygenase - metabolism</subject><subject>Arachidonate 5-Lipoxygenase</subject><subject>Arachidonate 5-Lipoxygenase - genetics</subject><subject>Arachidonate 5-Lipoxygenase - metabolism</subject><subject>Arachidonic Acid</subject><subject>Arachidonic Acid - metabolism</subject><subject>Blast Crisis</subject><subject>Blast Crisis - classification</subject><subject>Blast Crisis - enzymology</subject><subject>Blast Crisis - pathology</subject><subject>Calcium</subject><subject>Calcium - metabolism</subject><subject>Cell Proliferation</subject><subject>Hematology, Oncology and Palliative Medicine</subject><subject>Human leukemic blasts</subject><subject>Humans</subject><subject>Hydroxyeicosatetraenoic Acids</subject><subject>Hydroxyeicosatetraenoic Acids - secretion</subject><subject>Immunology</subject><subject>Ionophores</subject><subject>Ionophores - pharmacology</subject><subject>Leukemia, Myeloid, Acute</subject><subject>Leukemia, Myeloid, Acute - classification</subject><subject>Leukemia, Myeloid, Acute - enzymology</subject><subject>Leukemia, Myeloid, Acute - pathology</subject><subject>Leukotriene B4</subject><subject>Leukotriene B4 - secretion</subject><subject>Life Sciences</subject><subject>Lipoxygenase</subject><subject>LTB 4</subject><subject>Polymerase Chain Reaction</subject><subject>Precursor Cell Lymphoblastic Leukemia-Lymphoma</subject><subject>Precursor Cell Lymphoblastic Leukemia-Lymphoma - classification</subject><subject>Precursor Cell Lymphoblastic Leukemia-Lymphoma - enzymology</subject><subject>Precursor Cell Lymphoblastic Leukemia-Lymphoma - pathology</subject><subject>RNA, Messenger</subject><subject>RNA, Messenger - genetics</subject><subject>RNA, Messenger - metabolism</subject><subject>Thromboxane A2</subject><subject>Thromboxane A2 - secretion</subject><issn>0145-2126</issn><issn>1873-5835</issn><issn>0145-2126</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkt9rFDEQx4Mo9jz9E5Q8CYK7nSSbbPKilENt4cCHKvgWstlZmuv-qMluof-9We9Q6EtfMjD5zHeG-Q4hbxmUDJg6P5Q9LrcRU8kBdAmyBJDPyIbpWhRSC_mcbIBVsuCMqzPyKqUDZMIw85KcMS0VM8ZsyE4W---_PlLG10jd2FL2N0XDSMMwuHmJSLspDolOHb1ZBjfStTMOwdOmd2lOr8mLzvUJ35zilvz8-uXH7jLLfLvaXewLX2kxF_lRdd2gESAq3vhOC6E0aIdVnqutm_zb1V3XcsFb5Y3mNXa-MSCVqphAsSUfjro3rrd3MQwuPtjJBXt5sbdrDrJwlcvuWWbfH9m7OP1eMM12CMlj37sRpyVZZYTQmX8SZEaCYpncEnkEfZxSitj9G4GBXS2xB3uyxK6WWJB5IJnr3p0aLM2A7f-qkwcZ-HwEMO_uPmC0yQccPbYhop9tO4UnW3x6pOD7MAbv-lt8wHSYljhmYyyziVuw1-tdrGcBeQO8qkD8AZEkr1w</recordid><startdate>20081101</startdate><enddate>20081101</enddate><creator>Vincent, Christelle</creator><creator>Fiancette, Rémi</creator><creator>Donnard, Magali</creator><creator>Bordessoule, Dominique</creator><creator>Turlure, Pascal</creator><creator>Trimoreau, Franck</creator><creator>Denizot, Yves</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope><scope>1XC</scope><orcidid>https://orcid.org/0000-0002-5799-980X</orcidid></search><sort><creationdate>20081101</creationdate><title>5-LOX, 12-LOX and 15-LOX in immature forms of human leukemic blasts</title><author>Vincent, Christelle ; Fiancette, Rémi ; Donnard, Magali ; Bordessoule, Dominique ; Turlure, Pascal ; Trimoreau, Franck ; Denizot, Yves</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c483t-483677be930342bcf8336808ae4059d7b677f7ffd232d6c9827efcb90566413e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>12-HETE</topic><topic>12-Hydroxy-5,8,10,14-eicosatetraenoic Acid</topic><topic>12-Hydroxy-5,8,10,14-eicosatetraenoic Acid - secretion</topic><topic>12-LOX</topic><topic>15-HETE</topic><topic>15-LOX</topic><topic>5-LOX</topic><topic>Apoptosis</topic><topic>Apoptosis - physiology</topic><topic>Arachidonate 12-Lipoxygenase</topic><topic>Arachidonate 12-Lipoxygenase - genetics</topic><topic>Arachidonate 12-Lipoxygenase - metabolism</topic><topic>Arachidonate 15-Lipoxygenase</topic><topic>Arachidonate 15-Lipoxygenase - genetics</topic><topic>Arachidonate 15-Lipoxygenase - metabolism</topic><topic>Arachidonate 5-Lipoxygenase</topic><topic>Arachidonate 5-Lipoxygenase - genetics</topic><topic>Arachidonate 5-Lipoxygenase - metabolism</topic><topic>Arachidonic Acid</topic><topic>Arachidonic Acid - metabolism</topic><topic>Blast Crisis</topic><topic>Blast Crisis - classification</topic><topic>Blast Crisis - enzymology</topic><topic>Blast Crisis - pathology</topic><topic>Calcium</topic><topic>Calcium - metabolism</topic><topic>Cell Proliferation</topic><topic>Hematology, Oncology and Palliative Medicine</topic><topic>Human leukemic blasts</topic><topic>Humans</topic><topic>Hydroxyeicosatetraenoic Acids</topic><topic>Hydroxyeicosatetraenoic Acids - secretion</topic><topic>Immunology</topic><topic>Ionophores</topic><topic>Ionophores - pharmacology</topic><topic>Leukemia, Myeloid, Acute</topic><topic>Leukemia, Myeloid, Acute - classification</topic><topic>Leukemia, Myeloid, Acute - enzymology</topic><topic>Leukemia, Myeloid, Acute - pathology</topic><topic>Leukotriene B4</topic><topic>Leukotriene B4 - secretion</topic><topic>Life Sciences</topic><topic>Lipoxygenase</topic><topic>LTB 4</topic><topic>Polymerase Chain Reaction</topic><topic>Precursor Cell Lymphoblastic Leukemia-Lymphoma</topic><topic>Precursor Cell Lymphoblastic Leukemia-Lymphoma - classification</topic><topic>Precursor Cell Lymphoblastic Leukemia-Lymphoma - enzymology</topic><topic>Precursor Cell Lymphoblastic Leukemia-Lymphoma - pathology</topic><topic>RNA, Messenger</topic><topic>RNA, Messenger - genetics</topic><topic>RNA, Messenger - metabolism</topic><topic>Thromboxane A2</topic><topic>Thromboxane A2 - secretion</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Vincent, Christelle</creatorcontrib><creatorcontrib>Fiancette, Rémi</creatorcontrib><creatorcontrib>Donnard, Magali</creatorcontrib><creatorcontrib>Bordessoule, Dominique</creatorcontrib><creatorcontrib>Turlure, Pascal</creatorcontrib><creatorcontrib>Trimoreau, Franck</creatorcontrib><creatorcontrib>Denizot, Yves</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><jtitle>Leukemia research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Vincent, Christelle</au><au>Fiancette, Rémi</au><au>Donnard, Magali</au><au>Bordessoule, Dominique</au><au>Turlure, Pascal</au><au>Trimoreau, Franck</au><au>Denizot, Yves</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>5-LOX, 12-LOX and 15-LOX in immature forms of human leukemic blasts</atitle><jtitle>Leukemia research</jtitle><addtitle>Leuk Res</addtitle><date>2008-11-01</date><risdate>2008</risdate><volume>32</volume><issue>11</issue><spage>1756</spage><epage>1762</epage><pages>1756-1762</pages><issn>0145-2126</issn><eissn>1873-5835</eissn><eissn>0145-2126</eissn><abstract>Abstract Several reports have demonstrated an important role of leukotriene B4 (LTB4 ) in the immune system. We investigated whether leukemic blasts from acute myeloid leukemic (AML) and acute lymphoid leukemic (ALL) patients produced LTB4 , 12- and 15-hydroxyeicosatetraenoic acids (12-HETE and 15-HETE) and whether these compounds affected blast proliferation and apoptosis. Leukemic blasts from AML M0-2 and ALL patients expressed 5-LOX, 12-LOX and 15-LOX transcripts. Quantitative polymerase chain reaction indicated that 5-LOX transcripts were far more abundant than 12-LOX and 15-LOX ones. Leukemic blasts expressed 5-LOX activating protein (FLAP) transcripts and produced LTB4 in response to calcium ionophore. In contrast no 15-HETE production was found. Calcium ionophore-stimulated leukemic blasts produced 12-HETE but also released thromboxane A2 suggesting that contaminating platelets accounted for the release of these compounds. No significant effect of LTB4 , 12-HETE or 15-HETE could be documented on leukemic blast growth and on their apoptose rate. Results of the present study indicate that immature form of leukemic blasts produce LTB4 . However, the three major lipoxygenase metabolites of arachidonic acid; i.e., LTB4 , 12-HETE or 15-HETE, had no evident effect on their growth and apoptosis. We may speculate that LTB4 -derived blast cells might initiate, augment or prolong tissue inflammation and damages by affecting the marrow and blood cytokine network.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>18561999</pmid><doi>10.1016/j.leukres.2008.05.005</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-5799-980X</orcidid></addata></record> |
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| ispartof | Leukemia research, 2008-11, Vol.32 (11), p.1756-1762 |
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| subjects | 12-HETE 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid - secretion 12-LOX 15-HETE 15-LOX 5-LOX Apoptosis Apoptosis - physiology Arachidonate 12-Lipoxygenase Arachidonate 12-Lipoxygenase - genetics Arachidonate 12-Lipoxygenase - metabolism Arachidonate 15-Lipoxygenase Arachidonate 15-Lipoxygenase - genetics Arachidonate 15-Lipoxygenase - metabolism Arachidonate 5-Lipoxygenase Arachidonate 5-Lipoxygenase - genetics Arachidonate 5-Lipoxygenase - metabolism Arachidonic Acid Arachidonic Acid - metabolism Blast Crisis Blast Crisis - classification Blast Crisis - enzymology Blast Crisis - pathology Calcium Calcium - metabolism Cell Proliferation Hematology, Oncology and Palliative Medicine Human leukemic blasts Humans Hydroxyeicosatetraenoic Acids Hydroxyeicosatetraenoic Acids - secretion Immunology Ionophores Ionophores - pharmacology Leukemia, Myeloid, Acute Leukemia, Myeloid, Acute - classification Leukemia, Myeloid, Acute - enzymology Leukemia, Myeloid, Acute - pathology Leukotriene B4 Leukotriene B4 - secretion Life Sciences Lipoxygenase LTB 4 Polymerase Chain Reaction Precursor Cell Lymphoblastic Leukemia-Lymphoma Precursor Cell Lymphoblastic Leukemia-Lymphoma - classification Precursor Cell Lymphoblastic Leukemia-Lymphoma - enzymology Precursor Cell Lymphoblastic Leukemia-Lymphoma - pathology RNA, Messenger RNA, Messenger - genetics RNA, Messenger - metabolism Thromboxane A2 Thromboxane A2 - secretion |
| title | 5-LOX, 12-LOX and 15-LOX in immature forms of human leukemic blasts |
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