Fast non-genomic effects of progesterone-derived neurosteroids on nociceptive thresholds and pain symptoms

Fast Inhibitory controls mediated by glycine (GlyRs) and GABAA receptors (GABAARs) play an important role to prevent the apparition of pathological pain symptoms of allodynia and hyperalgesia. The use of positive allosteric modulators of these receptors, specifically expressed in the spinal cord, ma...

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Veröffentlicht in:	Pain (Amsterdam) 2008-10, Vol.139 (3), p.603-609
Hauptverfasser:	Charlet, Alexandre, Lasbennes, François, Darbon, Pascal, Poisbeau, Pierrick
Format:	Artikel
Sprache:	eng
Schlagworte:	Allopregnanolone Allosteric Regulation Analgesics, Non-Narcotic - pharmacology Analgesics, Non-Narcotic - therapeutic use Animals Bicuculline - toxicity Biological and medical sciences Carrageenan Carrageenan - toxicity Drug Evaluation, Preclinical Fundamental and applied biological sciences. Psychology GABAA receptor Glycine receptor Hot Temperature - adverse effects Hyperalgesia - drug therapy Hyperalgesia - physiopathology Inflammation - chemically induced Inflammation - drug therapy Inflammation - physiopathology Inflammatory pain Life Sciences Male Mechanical allodynia Medical sciences Molecular Conformation Nervous system (semeiology, syndromes) Nervous system as a whole Neurology Neurons and Cognition Neurosteroid Pain Threshold - drug effects Pain Threshold - physiology Pregnanolone - chemistry Pregnanolone - pharmacology Pregnanolone - therapeutic use Progesterone Rats Rats, Sprague-Dawley Receptors, GABA-A - drug effects Receptors, Glycine - drug effects Somesthesis and somesthetic pathways (proprioception, exteroception, nociception) interoception electrolocation. Sensory receptors Spinal cord Spinal Cord - drug effects Spinal inhibition Stereoisomerism Structure-Activity Relationship Strychnine - toxicity Thermal heat hyperalgesia Touch Vertebrates: nervous system and sense organs
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