Structural basis for recognition of hemi-methylated DNA by the SRA domain of human UHRF1

Epigenetic inheritance in mammals is characterized by high-fidelity replication of CpG methylation patterns during development. UHRF1 (also known as ICBP90 in humans and Np95 in mouse) is an E3 ligase important for the maintenance of global and local DNA methylation in vivo. The preferential affinit...

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Veröffentlicht in:	Nature 2008-10, Vol.455 (7214), p.822-825
Hauptverfasser:	Walker, John R, Duan, Shili, Dhe-Paganon, Sirano, Avvakumov, George V, Li, Yanjun, Arrowsmith, Cheryl H, Xue, Sheng, Bronner, Christian
Format:	Artikel
Sprache:	eng
Schlagworte:	5-Methylcytosine - metabolism 60 APPLIED LIFE SCIENCES AFFINITY BASIC BIOLOGICAL SCIENCES Binding Sites Biochemistry Biological and medical sciences CCAAT-Enhancer-Binding Proteins - chemistry CCAAT-Enhancer-Binding Proteins - metabolism CpG Islands - genetics CRYSTAL STRUCTURE Crystalline structure Crystallography, X-Ray DATA DEOXYCYTIDINE Deoxyribonucleic acid DNA DNA (Cytosine-5-)-Methyltransferase 1 DNA (Cytosine-5-)-Methyltransferases - metabolism DNA - chemistry DNA - genetics DNA - metabolism DNA Methylation DNA-ligand interactions Enzymes Epigenesis, Genetic Epigenetic inheritance Fundamental and applied biological sciences. Psychology GENETICS HUMAN POPULATIONS Humanities and Social Sciences Humans IN VIVO letter LIGASES MAINTENANCE MAMMALS MAN METHYL TRANSFERASES METHYLATION MICE Models, Molecular Molecular biophysics Molecular Conformation multidisciplinary MUTAGENESIS Nucleotide sequence Physiological aspects Protein Structure, Tertiary PROTEINS Science Science (multidisciplinary) SPECIFICITY Structure in molecular biology Ubiquitin UNITS
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