MAPK and JNK transduction pathways can phosphorylate Sp1 to activate the uPA minimal promoter element and endogenous gene transcription
Two upstream regions of the human urokinase (uPA) gene regulate its transcription: the minimal promoter (MP) and the enhancer element. The activity of the minimal promoter is essential for basal uPA transcription in prostate adenocarcinoma PC3 cells. Binding of a phosphorylated Sp1 transcription fac...
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| Veröffentlicht in: | Blood 2004-07, Vol.104 (1), p.256-262 |
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| creator | Benasciutti, Elisa Pagès, Gilles Kenzior, Olga Folk, William Blasi, Francesco Crippa, Massimo P. |
| description | Two upstream regions of the human urokinase (uPA) gene regulate its transcription: the minimal promoter (MP) and the enhancer element. The activity of the minimal promoter is essential for basal uPA transcription in prostate adenocarcinoma PC3 cells. Binding of a phosphorylated Sp1 transcription factor is, in turn, essential for the activity of the MP. Here we report that the Jun kinase (JNK) pathway is required for the basal activity of the MP and for the expression of the endogenous uPA gene in PC3 cells and for activated transcription in LNCaP cells. On the other hand, the p42/p44 mitogen-activated protein kinase (MAPK) pathway activates uPA gene expression through Sp1 phosphorylation in HeLa, LNCaP, and CCL39-derivative cells that do not typically express uPA in basal conditions. In HeLa cells the dominant-negative form of JNK interferes with the p42/p44 MAPK activation of the uPA-MP. The results suggest that the stress-activated protein kinase (SAPK)/JNK pathway plays an important role in the phosphorylation of Sp1, which, in turn, leads to basal or activated transcription from the uPA-MP element. |
| doi_str_mv | 10.1182/blood-2003-08-2661 |
| format | Article |
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The activity of the minimal promoter is essential for basal uPA transcription in prostate adenocarcinoma PC3 cells. Binding of a phosphorylated Sp1 transcription factor is, in turn, essential for the activity of the MP. Here we report that the Jun kinase (JNK) pathway is required for the basal activity of the MP and for the expression of the endogenous uPA gene in PC3 cells and for activated transcription in LNCaP cells. On the other hand, the p42/p44 mitogen-activated protein kinase (MAPK) pathway activates uPA gene expression through Sp1 phosphorylation in HeLa, LNCaP, and CCL39-derivative cells that do not typically express uPA in basal conditions. In HeLa cells the dominant-negative form of JNK interferes with the p42/p44 MAPK activation of the uPA-MP. The results suggest that the stress-activated protein kinase (SAPK)/JNK pathway plays an important role in the phosphorylation of Sp1, which, in turn, leads to basal or activated transcription from the uPA-MP element.</description><identifier>ISSN: 0006-4971</identifier><identifier>EISSN: 1528-0020</identifier><identifier>DOI: 10.1182/blood-2003-08-2661</identifier><identifier>PMID: 15031204</identifier><language>eng</language><publisher>Washington, DC: Elsevier Inc</publisher><subject>Animals ; Biochemistry, Molecular Biology ; Biological and medical sciences ; Butadienes ; Butadienes - pharmacology ; Cancer ; Cell Line, Tumor ; Cricetinae ; Cricetulus ; Dose-Response Relationship, Drug ; Enzyme Activation ; Enzyme Activation - genetics ; Enzyme Inhibitors ; Enzyme Inhibitors - pharmacology ; Fibroblasts ; Fibroblasts - cytology ; Fibroblasts - metabolism ; General aspects (metabolism, cell proliferation, established cell line...) ; Genes, Reporter ; Genes, Reporter - genetics ; HeLa Cells ; Humans ; JNK Mitogen-Activated Protein Kinases ; Life Sciences ; MAP Kinase Signaling System ; Medical sciences ; Mitogen-Activated Protein Kinase 1 ; Mitogen-Activated Protein Kinase 1 - antagonists & inhibitors ; Mitogen-Activated Protein Kinase 1 - genetics ; Mitogen-Activated Protein Kinase 1 - metabolism ; Mitogen-Activated Protein Kinase 1 - pharmacology ; Mitogen-Activated Protein Kinase 3 ; Mitogen-Activated Protein Kinases ; Mitogen-Activated Protein Kinases - antagonists & inhibitors ; Mitogen-Activated Protein Kinases - genetics ; Mitogen-Activated Protein Kinases - metabolism ; Mitogen-Activated Protein Kinases - pharmacology ; Molecular biology ; Nitriles ; Nitriles - pharmacology ; Phosphorylation ; Promoter Regions (Genetics) ; Promoter Regions, Genetic - genetics ; Recombinant Proteins ; Recombinant Proteins - genetics ; Recombinant Proteins - metabolism ; RNA, Messenger ; RNA, Messenger - biosynthesis ; Sp1 Transcription Factor ; Sp1 Transcription Factor - metabolism ; Trans-Activation (Genetics) ; Transcriptional Activation - drug effects ; Tumor cell ; Tumors ; Urinary Plasminogen Activator ; Urokinase-Type Plasminogen Activator - biosynthesis ; Urokinase-Type Plasminogen Activator - genetics</subject><ispartof>Blood, 2004-07, Vol.104 (1), p.256-262</ispartof><rights>2004 American Society of Hematology</rights><rights>2004 INIST-CNRS</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c526t-53faf496850d56d85bb956ee5dda3440229a59779db649564e334fbaab18a40f3</citedby><cites>FETCH-LOGICAL-c526t-53faf496850d56d85bb956ee5dda3440229a59779db649564e334fbaab18a40f3</cites><orcidid>0000-0002-8466-5610</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,27903,27904</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15995936$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15031204$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.science/hal-00323627$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Benasciutti, Elisa</creatorcontrib><creatorcontrib>Pagès, Gilles</creatorcontrib><creatorcontrib>Kenzior, Olga</creatorcontrib><creatorcontrib>Folk, William</creatorcontrib><creatorcontrib>Blasi, Francesco</creatorcontrib><creatorcontrib>Crippa, Massimo P.</creatorcontrib><title>MAPK and JNK transduction pathways can phosphorylate Sp1 to activate the uPA minimal promoter element and endogenous gene transcription</title><title>Blood</title><addtitle>Blood</addtitle><description>Two upstream regions of the human urokinase (uPA) gene regulate its transcription: the minimal promoter (MP) and the enhancer element. The activity of the minimal promoter is essential for basal uPA transcription in prostate adenocarcinoma PC3 cells. Binding of a phosphorylated Sp1 transcription factor is, in turn, essential for the activity of the MP. Here we report that the Jun kinase (JNK) pathway is required for the basal activity of the MP and for the expression of the endogenous uPA gene in PC3 cells and for activated transcription in LNCaP cells. On the other hand, the p42/p44 mitogen-activated protein kinase (MAPK) pathway activates uPA gene expression through Sp1 phosphorylation in HeLa, LNCaP, and CCL39-derivative cells that do not typically express uPA in basal conditions. In HeLa cells the dominant-negative form of JNK interferes with the p42/p44 MAPK activation of the uPA-MP. The results suggest that the stress-activated protein kinase (SAPK)/JNK pathway plays an important role in the phosphorylation of Sp1, which, in turn, leads to basal or activated transcription from the uPA-MP element.</description><subject>Animals</subject><subject>Biochemistry, Molecular Biology</subject><subject>Biological and medical sciences</subject><subject>Butadienes</subject><subject>Butadienes - pharmacology</subject><subject>Cancer</subject><subject>Cell Line, Tumor</subject><subject>Cricetinae</subject><subject>Cricetulus</subject><subject>Dose-Response Relationship, Drug</subject><subject>Enzyme Activation</subject><subject>Enzyme Activation - genetics</subject><subject>Enzyme Inhibitors</subject><subject>Enzyme Inhibitors - pharmacology</subject><subject>Fibroblasts</subject><subject>Fibroblasts - cytology</subject><subject>Fibroblasts - metabolism</subject><subject>General aspects (metabolism, cell proliferation, established cell line...)</subject><subject>Genes, Reporter</subject><subject>Genes, Reporter - genetics</subject><subject>HeLa Cells</subject><subject>Humans</subject><subject>JNK Mitogen-Activated Protein Kinases</subject><subject>Life Sciences</subject><subject>MAP Kinase Signaling System</subject><subject>Medical sciences</subject><subject>Mitogen-Activated Protein Kinase 1</subject><subject>Mitogen-Activated Protein Kinase 1 - antagonists & inhibitors</subject><subject>Mitogen-Activated Protein Kinase 1 - genetics</subject><subject>Mitogen-Activated Protein Kinase 1 - metabolism</subject><subject>Mitogen-Activated Protein Kinase 1 - pharmacology</subject><subject>Mitogen-Activated Protein Kinase 3</subject><subject>Mitogen-Activated Protein Kinases</subject><subject>Mitogen-Activated Protein Kinases - antagonists & inhibitors</subject><subject>Mitogen-Activated Protein Kinases - genetics</subject><subject>Mitogen-Activated Protein Kinases - metabolism</subject><subject>Mitogen-Activated Protein Kinases - pharmacology</subject><subject>Molecular biology</subject><subject>Nitriles</subject><subject>Nitriles - pharmacology</subject><subject>Phosphorylation</subject><subject>Promoter Regions (Genetics)</subject><subject>Promoter Regions, Genetic - genetics</subject><subject>Recombinant Proteins</subject><subject>Recombinant Proteins - genetics</subject><subject>Recombinant Proteins - metabolism</subject><subject>RNA, Messenger</subject><subject>RNA, Messenger - biosynthesis</subject><subject>Sp1 Transcription Factor</subject><subject>Sp1 Transcription Factor - metabolism</subject><subject>Trans-Activation (Genetics)</subject><subject>Transcriptional Activation - drug effects</subject><subject>Tumor cell</subject><subject>Tumors</subject><subject>Urinary Plasminogen Activator</subject><subject>Urokinase-Type Plasminogen Activator - biosynthesis</subject><subject>Urokinase-Type Plasminogen Activator - genetics</subject><issn>0006-4971</issn><issn>1528-0020</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc1u1DAUhS1ERYfCC7BA3rBgEfD_JBKbUQUUOi2VgLXl2DeMURJHtmfQPAGvjdOMgFUX1tW1v-N7dQ5CLyh5Q2nN3rZ9CK5ihPCK1BVTij5CKypZXRHCyGO0IoSoSjRreo6epvSTECo4k0_QOZWEU0bECv2-2dxdYzM6_Pn2GudoxuT2Nvsw4snk3S9zTNia0uxCKicee5MBf50ozgGbAh7mPu8A7-82ePCjH0yPpxiGkCFi6GGAMd8PgNGFHzCGfcKlwDLMRj_N056hs870CZ6f6gX6_uH9t8uravvl46fLzbaykqlcSd6ZTjSqlsRJ5WrZto1UANI5w4UgjDVGNut141olyosAzkXXGtPS2gjS8Qv0evl3Z3o9xbJtPOpgvL7abPV8V9xkXLH1gRaWLayNIaUI3V8BJXpOQN8noOcENKn1nEARvVxE074dwP2TnCwvwKsTYJI1fVdcsD79xzWNbLgq3LuFg2LHwUPUyXoYLTgfwWbtgn9ojz9IzKUQ</recordid><startdate>20040701</startdate><enddate>20040701</enddate><creator>Benasciutti, Elisa</creator><creator>Pagès, Gilles</creator><creator>Kenzior, Olga</creator><creator>Folk, William</creator><creator>Blasi, Francesco</creator><creator>Crippa, Massimo P.</creator><general>Elsevier Inc</general><general>The Americain Society of Hematology</general><general>American Society of Hematology</general><scope>6I.</scope><scope>AAFTH</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>1XC</scope><orcidid>https://orcid.org/0000-0002-8466-5610</orcidid></search><sort><creationdate>20040701</creationdate><title>MAPK and JNK transduction pathways can phosphorylate Sp1 to activate the uPA minimal promoter element and endogenous gene transcription</title><author>Benasciutti, Elisa ; Pagès, Gilles ; Kenzior, Olga ; Folk, William ; Blasi, Francesco ; Crippa, Massimo P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c526t-53faf496850d56d85bb956ee5dda3440229a59779db649564e334fbaab18a40f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Animals</topic><topic>Biochemistry, Molecular Biology</topic><topic>Biological and medical sciences</topic><topic>Butadienes</topic><topic>Butadienes - pharmacology</topic><topic>Cancer</topic><topic>Cell Line, Tumor</topic><topic>Cricetinae</topic><topic>Cricetulus</topic><topic>Dose-Response Relationship, Drug</topic><topic>Enzyme Activation</topic><topic>Enzyme Activation - genetics</topic><topic>Enzyme Inhibitors</topic><topic>Enzyme Inhibitors - pharmacology</topic><topic>Fibroblasts</topic><topic>Fibroblasts - cytology</topic><topic>Fibroblasts - metabolism</topic><topic>General aspects (metabolism, cell proliferation, established cell line...)</topic><topic>Genes, Reporter</topic><topic>Genes, Reporter - genetics</topic><topic>HeLa Cells</topic><topic>Humans</topic><topic>JNK Mitogen-Activated Protein Kinases</topic><topic>Life Sciences</topic><topic>MAP Kinase Signaling System</topic><topic>Medical sciences</topic><topic>Mitogen-Activated Protein Kinase 1</topic><topic>Mitogen-Activated Protein Kinase 1 - antagonists & inhibitors</topic><topic>Mitogen-Activated Protein Kinase 1 - genetics</topic><topic>Mitogen-Activated Protein Kinase 1 - metabolism</topic><topic>Mitogen-Activated Protein Kinase 1 - pharmacology</topic><topic>Mitogen-Activated Protein Kinase 3</topic><topic>Mitogen-Activated Protein Kinases</topic><topic>Mitogen-Activated Protein Kinases - antagonists & inhibitors</topic><topic>Mitogen-Activated Protein Kinases - genetics</topic><topic>Mitogen-Activated Protein Kinases - metabolism</topic><topic>Mitogen-Activated Protein Kinases - pharmacology</topic><topic>Molecular biology</topic><topic>Nitriles</topic><topic>Nitriles - pharmacology</topic><topic>Phosphorylation</topic><topic>Promoter Regions (Genetics)</topic><topic>Promoter Regions, Genetic - genetics</topic><topic>Recombinant Proteins</topic><topic>Recombinant Proteins - genetics</topic><topic>Recombinant Proteins - metabolism</topic><topic>RNA, Messenger</topic><topic>RNA, Messenger - biosynthesis</topic><topic>Sp1 Transcription Factor</topic><topic>Sp1 Transcription Factor - metabolism</topic><topic>Trans-Activation (Genetics)</topic><topic>Transcriptional Activation - drug effects</topic><topic>Tumor cell</topic><topic>Tumors</topic><topic>Urinary Plasminogen Activator</topic><topic>Urokinase-Type Plasminogen Activator - biosynthesis</topic><topic>Urokinase-Type Plasminogen Activator - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Benasciutti, Elisa</creatorcontrib><creatorcontrib>Pagès, Gilles</creatorcontrib><creatorcontrib>Kenzior, Olga</creatorcontrib><creatorcontrib>Folk, William</creatorcontrib><creatorcontrib>Blasi, Francesco</creatorcontrib><creatorcontrib>Crippa, Massimo P.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Hyper Article en Ligne (HAL)</collection><jtitle>Blood</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Benasciutti, Elisa</au><au>Pagès, Gilles</au><au>Kenzior, Olga</au><au>Folk, William</au><au>Blasi, Francesco</au><au>Crippa, Massimo P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>MAPK and JNK transduction pathways can phosphorylate Sp1 to activate the uPA minimal promoter element and endogenous gene transcription</atitle><jtitle>Blood</jtitle><addtitle>Blood</addtitle><date>2004-07-01</date><risdate>2004</risdate><volume>104</volume><issue>1</issue><spage>256</spage><epage>262</epage><pages>256-262</pages><issn>0006-4971</issn><eissn>1528-0020</eissn><abstract>Two upstream regions of the human urokinase (uPA) gene regulate its transcription: the minimal promoter (MP) and the enhancer element. The activity of the minimal promoter is essential for basal uPA transcription in prostate adenocarcinoma PC3 cells. Binding of a phosphorylated Sp1 transcription factor is, in turn, essential for the activity of the MP. Here we report that the Jun kinase (JNK) pathway is required for the basal activity of the MP and for the expression of the endogenous uPA gene in PC3 cells and for activated transcription in LNCaP cells. On the other hand, the p42/p44 mitogen-activated protein kinase (MAPK) pathway activates uPA gene expression through Sp1 phosphorylation in HeLa, LNCaP, and CCL39-derivative cells that do not typically express uPA in basal conditions. In HeLa cells the dominant-negative form of JNK interferes with the p42/p44 MAPK activation of the uPA-MP. The results suggest that the stress-activated protein kinase (SAPK)/JNK pathway plays an important role in the phosphorylation of Sp1, which, in turn, leads to basal or activated transcription from the uPA-MP element.</abstract><cop>Washington, DC</cop><pub>Elsevier Inc</pub><pmid>15031204</pmid><doi>10.1182/blood-2003-08-2661</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-8466-5610</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Animals Biochemistry, Molecular Biology Biological and medical sciences Butadienes Butadienes - pharmacology Cancer Cell Line, Tumor Cricetinae Cricetulus Dose-Response Relationship, Drug Enzyme Activation Enzyme Activation - genetics Enzyme Inhibitors Enzyme Inhibitors - pharmacology Fibroblasts Fibroblasts - cytology Fibroblasts - metabolism General aspects (metabolism, cell proliferation, established cell line...) Genes, Reporter Genes, Reporter - genetics HeLa Cells Humans JNK Mitogen-Activated Protein Kinases Life Sciences MAP Kinase Signaling System Medical sciences Mitogen-Activated Protein Kinase 1 Mitogen-Activated Protein Kinase 1 - antagonists & inhibitors Mitogen-Activated Protein Kinase 1 - genetics Mitogen-Activated Protein Kinase 1 - metabolism Mitogen-Activated Protein Kinase 1 - pharmacology Mitogen-Activated Protein Kinase 3 Mitogen-Activated Protein Kinases Mitogen-Activated Protein Kinases - antagonists & inhibitors Mitogen-Activated Protein Kinases - genetics Mitogen-Activated Protein Kinases - metabolism Mitogen-Activated Protein Kinases - pharmacology Molecular biology Nitriles Nitriles - pharmacology Phosphorylation Promoter Regions (Genetics) Promoter Regions, Genetic - genetics Recombinant Proteins Recombinant Proteins - genetics Recombinant Proteins - metabolism RNA, Messenger RNA, Messenger - biosynthesis Sp1 Transcription Factor Sp1 Transcription Factor - metabolism Trans-Activation (Genetics) Transcriptional Activation - drug effects Tumor cell Tumors Urinary Plasminogen Activator Urokinase-Type Plasminogen Activator - biosynthesis Urokinase-Type Plasminogen Activator - genetics |
| title | MAPK and JNK transduction pathways can phosphorylate Sp1 to activate the uPA minimal promoter element and endogenous gene transcription |
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